Risk of breast cancer among users of aspirin and other anti-inflammatory drugs. García Rodríguez, L. A. & González-Pérez, A. British Journal of Cancer, 91(3):525--529, August, 2004.
doi  abstract   bibtex   
We conducted a cohort study with a nested case-control analysis to evaluate the effect of anti-inflammatory drugs in breast cancer incidence using the General Practice Research Database. Women taking aspirin and paracetamol for 1 year or longer had an odds ratio (OR) of 0.77 (95 percent confidence interval (95% CI): 0.62,0.95) and 0.76 (95% CI: 0.65,0.88), respectively, compared to nonusers. Daily doses of aspirin (75 mg) and paracetamol (up to 2000 mg) showed the greatest reduced risk. Use of non-aspirin nonsteroidal anti-inflammatory drugs for more than 1 year was not associated with a reduced risk of breast cancer (OR=1.00 (95% CI: 0.84, 1.17), and the corresponding estimate among users with at least 2 years duration was similar. Our findings suggest that aspirin at cardioprophylactic doses as well as paracetamol at analgesic doses is associated with a reduced risk of breast cancer.
@article{garcia_rodriguez_risk_2004,
	title = {Risk of breast cancer among users of aspirin and other anti-inflammatory drugs},
	volume = {91},
	issn = {0007-0920},
	doi = {10.1038/sj.bjc.6602003},
	abstract = {We conducted a cohort study with a nested case-control analysis to evaluate the effect of anti-inflammatory drugs in breast cancer incidence using the General Practice Research Database. Women taking aspirin and paracetamol for 1 year or longer had an odds ratio (OR) of 0.77 (95 percent confidence interval (95\% CI): 0.62,0.95) and 0.76 (95\% CI: 0.65,0.88), respectively, compared to nonusers. Daily doses of aspirin (75 mg) and paracetamol (up to 2000 mg) showed the greatest reduced risk. Use of non-aspirin nonsteroidal anti-inflammatory drugs for more than 1 year was not associated with a reduced risk of breast cancer (OR=1.00 (95\% CI: 0.84, 1.17), and the corresponding estimate among users with at least 2 years duration was similar. Our findings suggest that aspirin at cardioprophylactic doses as well as paracetamol at analgesic doses is associated with a reduced risk of breast cancer.},
	language = {eng},
	number = {3},
	journal = {British Journal of Cancer},
	author = {García Rodríguez, L. A. and González-Pérez, A.},
	month = aug,
	year = {2004},
	pmid = {15226764},
	pmcid = {PMC2409835},
	keywords = {Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Breast Neoplasms, Case-Control Studies, Cohort Studies, Databases, Factual, Female, Humans, Middle Aged, Odds Ratio, Risk Assessment},
	pages = {525--529}
}
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