Towards a predictive model of electroporation-based therapies using pre-pulse electrical measurements. Garcia, P. A., Arena, C. B., & Davalos, R. V. Annu Int Conf IEEE Eng Med Biol Soc, 2012:2575-8, 2012. 2694-0604 Garcia, Paulo A Arena, Christopher B Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States 2013/02/01 Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:2575-8. doi: 10.1109/EMBC.2012.6346490.
doi  abstract   bibtex   
Electroporation-based therapies have been gaining momentum as minimally invasive techniques to facilitate transport of exogenous agents, or directly kill tumors and other undesirable tissue in a non-thermal manner. Typical procedures involve placing electrodes into or around the treatment area and delivering a series of short and intense electric pulses to the tissue/tumor. These pulses create defects in the cell membranes, inducing non-linear changes in the electric conductivity of the tissue. These dynamic conductivity changes redistribute the electric field, and thus the treatment volume. In this study, we develop a statistical model that can be used to determine the baseline conductivity of tissues prior to electroporation and is capable of predicting the non-linear current response with implications for treatment planning and outcome confirmation.
@article{RN204,
   author = {Garcia, P. A. and Arena, C. B. and Davalos, R. V.},
   title = {Towards a predictive model of electroporation-based therapies using pre-pulse electrical measurements},
   journal = {Annu Int Conf IEEE Eng Med Biol Soc},
   volume = {2012},
   pages = {2575-8},
   note = {2694-0604
Garcia, Paulo A
Arena, Christopher B
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
United States
2013/02/01
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:2575-8. doi: 10.1109/EMBC.2012.6346490.},
   abstract = {Electroporation-based therapies have been gaining momentum as minimally invasive techniques to facilitate transport of exogenous agents, or directly kill tumors and other undesirable tissue in a non-thermal manner. Typical procedures involve placing electrodes into or around the treatment area and delivering a series of short and intense electric pulses to the tissue/tumor. These pulses create defects in the cell membranes, inducing non-linear changes in the electric conductivity of the tissue. These dynamic conductivity changes redistribute the electric field, and thus the treatment volume. In this study, we develop a statistical model that can be used to determine the baseline conductivity of tissues prior to electroporation and is capable of predicting the non-linear current response with implications for treatment planning and outcome confirmation.},
   keywords = {Algorithms
Electric Conductivity
Electrochemotherapy/*methods
Electroporation
Humans},
   ISSN = {2375-7477},
   DOI = {10.1109/embc.2012.6346490},
   year = {2012},
   type = {Journal Article}
}

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