@article{ WOS:000411804500071,
Author = {Garcia, Paulo A. and Kos, Bor and Rossmeisl, Jr., John H. and Pavliha,
   Denis and Miklavcic, Damijan and Davalos, Rafael V.},
Title = {Predictive therapeutic planning for irreversible electroporation
   treatment of spontaneous malignant glioma},
Journal = {MEDICAL PHYSICS},
Year = {2017},
Volume = {44},
Number = {9},
Pages = {4968-4980},
Month = {SEP},
Abstract = {Purpose: Irreversible electroporation (IRE) has been developed as a
   promising minimally invasive treatment to ablate spontaneous brain
   tumors with pulsed electric fields in canine patients. The purpose of
   the study is to determine the Peleg-Fermi parameters needed to
   incorporate pulse number and pulse duration into the therapeutic
   planning of IRE.
   Methods: Seven canine patients were treated with IRE for spontaneous
   malignant glioma with MRIbased treatment planning. The treatment
   planning method consists of building patient-specific finite element
   models and using them to compute electric fields used in the IRE
   treatment. We evaluate the predictive power of tumor coverage with
   electric field alone vs. cell kill probability using radiographically
   confirmed clinical outcomes.
   Results: Results of post-treatment diagnostic imaging, tumor biopsies,
   and neurological examinations indicated successful tumor ablation
   without significant direct neurotoxicity in six of the seven dogs.
   Objective tumor responses were seen in four (80\%) of five dogs with
   quantifiable target lesions according to RANO criteria. Two dogs
   experienced survivals in excess of 1 yr, including one dog that resulted
   in complete response to IRE treatment for 5+ years to date. Tumor
   fraction exposed to electric field over 600 V/cm was between 0.08 and
   0.73, while tumor fraction exposed to electric field over 300 V/cm was
   between 0.17 and 0.95. Probability of cell kill of >= 90\% was found in
   tumor volume fractions between 0.21 and 0.99.
   Conclusions: We conclude that IRE is a safe and effective minimally
   invasive treatment for malignant glioma and can be predicted with the
   Peleg-Fermi cell kill probability function. A tumor coverage of >= 0.9
   at a cell kill probability >= 90\% can be used to guide IRE treatments
   of spontaneous malignant glioma based on the radiographically confirmed
   clinical outcomes achieved. (C) 2017 The Authors. Medical Physics
   published by Wiley Periodicals, Inc. on behalf of American Association
   of Physicists in Medicine.},
Publisher = {WILEY},
Address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA},
Type = {Article},
Language = {English},
Affiliation = {Garcia, PA (Corresponding Author), Wake Forest Univ, Sch Biomed Engn \& Sci, Virginia Tech, Blacksburg, VA 24061 USA.
   Garcia, PA (Corresponding Author), MIT, Dept Mech Engn, Lab Energy \& Microsyst Innovat, Cambridge, MA 02139 USA.
   Garcia, Paulo A.; Rossmeisl, John H., Jr.; Davalos, Rafael V., Wake Forest Univ, Sch Biomed Engn \& Sci, Virginia Tech, Blacksburg, VA 24061 USA.
   Garcia, Paulo A., MIT, Dept Mech Engn, Lab Energy \& Microsyst Innovat, Cambridge, MA 02139 USA.
   Kos, Bor; Pavliha, Denis; Miklavcic, Damijan, Univ Ljubljana, Fac Elect Engn, Trzaska 25, Ljubljana 1000, Slovenia.
   Rossmeisl, John H., Jr., Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24060 USA.
   Rossmeisl, John H., Jr., Virginia Maryland Reg Coll Vet Med, Vet \& Comparat Neurooncol Lab, Blacksburg, VA 24060 USA.},
DOI = {10.1002/mp.12401},
ISSN = {0094-2405},
EISSN = {2473-4209},
Keywords = {brain tumor; minimally invasive; neurosurgery; pulsed electric fields;
   treatment planning},
Keywords-Plus = {ELECTRIC-FIELD DISTRIBUTION; TECHNOLOGICAL APPROACH; PULSE AMPLITUDE;
   MODEL; TUMOR; GENE; ELECTROCHEMOTHERAPY; SYSTEM; SAFETY; ELECTROTRANSFER},
Research-Areas = {Radiology, Nuclear Medicine \& Medical Imaging},
Web-of-Science-Categories  = {Radiology, Nuclear Medicine \& Medical Imaging},
Author-Email = {pagarcia@mit.edu},
Affiliations = {Wake Forest University; Virginia Polytechnic Institute \& State
   University; Massachusetts Institute of Technology (MIT); University of
   Ljubljana},
ResearcherID-Numbers = {Miklavčič, Damijan/A-9497-2008
   Rossmeisl, John H/Q-7119-2016
   },
ORCID-Numbers = {Miklavčič, Damijan/0000-0003-3506-9449
   Kos, Bor/0000-0001-6219-7046},
Funding-Acknowledgement = {Wallace H. Coulter Foundation Early Career Translational Research
   Awards; National Science Foundation {[}CBET-0933335, CAREER
   CBET-1055913]; Slovenian Research Agency {[}BI-US/14-15-016, P2-0249,
   Z3-7126]; Div Of Chem, Bioeng, Env, \& Transp Sys; Directorate For
   Engineering {[}1055913] Funding Source: National Science Foundation},
Funding-Text = {This work was supported by the Wallace H. Coulter Foundation Early
   Career Translational Research Awards and the National Science Foundation
   CBET-0933335 and CAREER CBET-1055913. This research was supported in
   part by the Slovenian Research Agency (Grants BI-US/14-15-016, P2-0249
   and Z3-7126). It has been performed within the scope of LEA EBAM. The
   study was made possible due to networking efforts of the COST TD1104
   action (www.electroporation.net). AngioDynamics, Inc. loaned the
   NanoKnife System and manufactured the electrodes used in the study
   (www.angiodynamics.com).},
Number-of-Cited-References = {61},
Times-Cited = {43},
Usage-Count-Last-180-days = {2},
Usage-Count-Since-2013 = {13},
Journal-ISO = {Med. Phys.},
Doc-Delivery-Number = {FI2VF},
Web-of-Science-Index = {Science Citation Index Expanded (SCI-EXPANDED)},
Unique-ID = {WOS:000411804500071},
OA = {hybrid, Green Published},
DA = {2024-03-03},
}

{"_id":"ftou3wEqZwAzgfsGS","bibbaseid":"garcia-kos-rossmeisl-pavliha-miklavcic-davalos-predictivetherapeuticplanningforirreversibleelectroporationtreatmentofspontaneousmalignantglioma-2017","author_short":["Garcia, P. A.","Kos, B.","Rossmeisl","Pavliha, D.","Miklavcic, D.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Article","author":[{"propositions":[],"lastnames":["Garcia"],"firstnames":["Paulo","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kos"],"firstnames":["Bor"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Rossmeisl"],"suffixes":["Jr.",",","John","H."]},{"propositions":[],"lastnames":["Pavliha"],"firstnames":["Denis"],"suffixes":[]},{"propositions":[],"lastnames":["Miklavcic"],"firstnames":["Damijan"],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["Rafael","V."],"suffixes":[]}],"title":"Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma","journal":"MEDICAL PHYSICS","year":"2017","volume":"44","number":"9","pages":"4968-4980","month":"SEP","abstract":"Purpose: Irreversible electroporation (IRE) has been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to determine the Peleg-Fermi parameters needed to incorporate pulse number and pulse duration into the therapeutic planning of IRE. Methods: Seven canine patients were treated with IRE for spontaneous malignant glioma with MRIbased treatment planning. The treatment planning method consists of building patient-specific finite element models and using them to compute electric fields used in the IRE treatment. We evaluate the predictive power of tumor coverage with electric field alone vs. cell kill probability using radiographically confirmed clinical outcomes. Results: Results of post-treatment diagnostic imaging, tumor biopsies, and neurological examinations indicated successful tumor ablation without significant direct neurotoxicity in six of the seven dogs. Objective tumor responses were seen in four (80%) of five dogs with quantifiable target lesions according to RANO criteria. Two dogs experienced survivals in excess of 1 yr, including one dog that resulted in complete response to IRE treatment for 5+ years to date. Tumor fraction exposed to electric field over 600 V/cm was between 0.08 and 0.73, while tumor fraction exposed to electric field over 300 V/cm was between 0.17 and 0.95. Probability of cell kill of >= 90% was found in tumor volume fractions between 0.21 and 0.99. Conclusions: We conclude that IRE is a safe and effective minimally invasive treatment for malignant glioma and can be predicted with the Peleg-Fermi cell kill probability function. A tumor coverage of >= 0.9 at a cell kill probability >= 90% can be used to guide IRE treatments of spontaneous malignant glioma based on the radiographically confirmed clinical outcomes achieved. (C) 2017 The Authors. Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.","publisher":"WILEY","address":"111 RIVER ST, HOBOKEN 07030-5774, NJ USA","language":"English","affiliation":"Garcia, PA (Corresponding Author), Wake Forest Univ, Sch Biomed Engn & Sci, Virginia Tech, Blacksburg, VA 24061 USA. Garcia, PA (Corresponding Author), MIT, Dept Mech Engn, Lab Energy & Microsyst Innovat, Cambridge, MA 02139 USA. Garcia, Paulo A.; Rossmeisl, John H., Jr.; Davalos, Rafael V., Wake Forest Univ, Sch Biomed Engn & Sci, Virginia Tech, Blacksburg, VA 24061 USA. Garcia, Paulo A., MIT, Dept Mech Engn, Lab Energy & Microsyst Innovat, Cambridge, MA 02139 USA. Kos, Bor; Pavliha, Denis; Miklavcic, Damijan, Univ Ljubljana, Fac Elect Engn, Trzaska 25, Ljubljana 1000, Slovenia. Rossmeisl, John H., Jr., Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24060 USA. Rossmeisl, John H., Jr., Virginia Maryland Reg Coll Vet Med, Vet & Comparat Neurooncol Lab, Blacksburg, VA 24060 USA.","doi":"10.1002/mp.12401","issn":"0094-2405","eissn":"2473-4209","keywords":"brain tumor; minimally invasive; neurosurgery; pulsed electric fields; treatment planning","keywords-plus":"ELECTRIC-FIELD DISTRIBUTION; TECHNOLOGICAL APPROACH; PULSE AMPLITUDE; MODEL; TUMOR; GENE; ELECTROCHEMOTHERAPY; SYSTEM; SAFETY; ELECTROTRANSFER","research-areas":"Radiology, Nuclear Medicine & Medical Imaging","web-of-science-categories":"Radiology, Nuclear Medicine & Medical Imaging","author-email":"pagarcia@mit.edu","affiliations":"Wake Forest University; Virginia Polytechnic Institute & State University; Massachusetts Institute of Technology (MIT); University of Ljubljana","researcherid-numbers":"Miklavčič, Damijan/A-9497-2008 Rossmeisl, John H/Q-7119-2016 ","orcid-numbers":"Miklavčič, Damijan/0000-0003-3506-9449 Kos, Bor/0000-0001-6219-7046","funding-acknowledgement":"Wallace H. Coulter Foundation Early Career Translational Research Awards; National Science Foundation [CBET-0933335, CAREER CBET-1055913]; Slovenian Research Agency [BI-US/14-15-016, P2-0249, Z3-7126]; Div Of Chem, Bioeng, Env, & Transp Sys; Directorate For Engineering [1055913] Funding Source: National Science Foundation","funding-text":"This work was supported by the Wallace H. Coulter Foundation Early Career Translational Research Awards and the National Science Foundation CBET-0933335 and CAREER CBET-1055913. This research was supported in part by the Slovenian Research Agency (Grants BI-US/14-15-016, P2-0249 and Z3-7126). It has been performed within the scope of LEA EBAM. The study was made possible due to networking efforts of the COST TD1104 action (www.electroporation.net). AngioDynamics, Inc. loaned the NanoKnife System and manufactured the electrodes used in the study (www.angiodynamics.com).","number-of-cited-references":"61","times-cited":"43","usage-count-last-180-days":"2","usage-count-since-2013":"13","journal-iso":"Med. Phys.","doc-delivery-number":"FI2VF","web-of-science-index":"Science Citation Index Expanded (SCI-EXPANDED)","unique-id":"WOS:000411804500071","oa":"hybrid, Green Published","da":"2024-03-03","bibtex":"@article{ WOS:000411804500071,\nAuthor = {Garcia, Paulo A. and Kos, Bor and Rossmeisl, Jr., John H. and Pavliha,\n Denis and Miklavcic, Damijan and Davalos, Rafael V.},\nTitle = {Predictive therapeutic planning for irreversible electroporation\n treatment of spontaneous malignant glioma},\nJournal = {MEDICAL PHYSICS},\nYear = {2017},\nVolume = {44},\nNumber = {9},\nPages = {4968-4980},\nMonth = {SEP},\nAbstract = {Purpose: Irreversible electroporation (IRE) has been developed as a\n promising minimally invasive treatment to ablate spontaneous brain\n tumors with pulsed electric fields in canine patients. The purpose of\n the study is to determine the Peleg-Fermi parameters needed to\n incorporate pulse number and pulse duration into the therapeutic\n planning of IRE.\n Methods: Seven canine patients were treated with IRE for spontaneous\n malignant glioma with MRIbased treatment planning. The treatment\n planning method consists of building patient-specific finite element\n models and using them to compute electric fields used in the IRE\n treatment. We evaluate the predictive power of tumor coverage with\n electric field alone vs. cell kill probability using radiographically\n confirmed clinical outcomes.\n Results: Results of post-treatment diagnostic imaging, tumor biopsies,\n and neurological examinations indicated successful tumor ablation\n without significant direct neurotoxicity in six of the seven dogs.\n Objective tumor responses were seen in four (80\\%) of five dogs with\n quantifiable target lesions according to RANO criteria. Two dogs\n experienced survivals in excess of 1 yr, including one dog that resulted\n in complete response to IRE treatment for 5+ years to date. Tumor\n fraction exposed to electric field over 600 V/cm was between 0.08 and\n 0.73, while tumor fraction exposed to electric field over 300 V/cm was\n between 0.17 and 0.95. Probability of cell kill of >= 90\\% was found in\n tumor volume fractions between 0.21 and 0.99.\n Conclusions: We conclude that IRE is a safe and effective minimally\n invasive treatment for malignant glioma and can be predicted with the\n Peleg-Fermi cell kill probability function. A tumor coverage of >= 0.9\n at a cell kill probability >= 90\\% can be used to guide IRE treatments\n of spontaneous malignant glioma based on the radiographically confirmed\n clinical outcomes achieved. (C) 2017 The Authors. Medical Physics\n published by Wiley Periodicals, Inc. on behalf of American Association\n of Physicists in Medicine.},\nPublisher = {WILEY},\nAddress = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA},\nType = {Article},\nLanguage = {English},\nAffiliation = {Garcia, PA (Corresponding Author), Wake Forest Univ, Sch Biomed Engn \\& Sci, Virginia Tech, Blacksburg, VA 24061 USA.\n Garcia, PA (Corresponding Author), MIT, Dept Mech Engn, Lab Energy \\& Microsyst Innovat, Cambridge, MA 02139 USA.\n Garcia, Paulo A.; Rossmeisl, John H., Jr.; Davalos, Rafael V., Wake Forest Univ, Sch Biomed Engn \\& Sci, Virginia Tech, Blacksburg, VA 24061 USA.\n Garcia, Paulo A., MIT, Dept Mech Engn, Lab Energy \\& Microsyst Innovat, Cambridge, MA 02139 USA.\n Kos, Bor; Pavliha, Denis; Miklavcic, Damijan, Univ Ljubljana, Fac Elect Engn, Trzaska 25, Ljubljana 1000, Slovenia.\n Rossmeisl, John H., Jr., Virginia Maryland Reg Coll Vet Med, Dept Small Anim Clin Sci, Blacksburg, VA 24060 USA.\n Rossmeisl, John H., Jr., Virginia Maryland Reg Coll Vet Med, Vet \\& Comparat Neurooncol Lab, Blacksburg, VA 24060 USA.},\nDOI = {10.1002/mp.12401},\nISSN = {0094-2405},\nEISSN = {2473-4209},\nKeywords = {brain tumor; minimally invasive; neurosurgery; pulsed electric fields;\n treatment planning},\nKeywords-Plus = {ELECTRIC-FIELD DISTRIBUTION; TECHNOLOGICAL APPROACH; PULSE AMPLITUDE;\n MODEL; TUMOR; GENE; ELECTROCHEMOTHERAPY; SYSTEM; SAFETY; ELECTROTRANSFER},\nResearch-Areas = {Radiology, Nuclear Medicine \\& Medical Imaging},\nWeb-of-Science-Categories = {Radiology, Nuclear Medicine \\& Medical Imaging},\nAuthor-Email = {pagarcia@mit.edu},\nAffiliations = {Wake Forest University; Virginia Polytechnic Institute \\& State\n University; Massachusetts Institute of Technology (MIT); University of\n Ljubljana},\nResearcherID-Numbers = {Miklavčič, Damijan/A-9497-2008\n Rossmeisl, John H/Q-7119-2016\n },\nORCID-Numbers = {Miklavčič, Damijan/0000-0003-3506-9449\n Kos, Bor/0000-0001-6219-7046},\nFunding-Acknowledgement = {Wallace H. Coulter Foundation Early Career Translational Research\n Awards; National Science Foundation {[}CBET-0933335, CAREER\n CBET-1055913]; Slovenian Research Agency {[}BI-US/14-15-016, P2-0249,\n Z3-7126]; Div Of Chem, Bioeng, Env, \\& Transp Sys; Directorate For\n Engineering {[}1055913] Funding Source: National Science Foundation},\nFunding-Text = {This work was supported by the Wallace H. Coulter Foundation Early\n Career Translational Research Awards and the National Science Foundation\n CBET-0933335 and CAREER CBET-1055913. This research was supported in\n part by the Slovenian Research Agency (Grants BI-US/14-15-016, P2-0249\n and Z3-7126). It has been performed within the scope of LEA EBAM. The\n study was made possible due to networking efforts of the COST TD1104\n action (www.electroporation.net). AngioDynamics, Inc. loaned the\n NanoKnife System and manufactured the electrodes used in the study\n (www.angiodynamics.com).},\nNumber-of-Cited-References = {61},\nTimes-Cited = {43},\nUsage-Count-Last-180-days = {2},\nUsage-Count-Since-2013 = {13},\nJournal-ISO = {Med. Phys.},\nDoc-Delivery-Number = {FI2VF},\nWeb-of-Science-Index = {Science Citation Index Expanded (SCI-EXPANDED)},\nUnique-ID = {WOS:000411804500071},\nOA = {hybrid, Green Published},\nDA = {2024-03-03},\n}\n\n","author_short":["Garcia, P. A.","Kos, B.","Rossmeisl","Pavliha, D.","Miklavcic, D.","Davalos, R. V."],"key":"WOS:000411804500071","id":"WOS:000411804500071","bibbaseid":"garcia-kos-rossmeisl-pavliha-miklavcic-davalos-predictivetherapeuticplanningforirreversibleelectroporationtreatmentofspontaneousmalignantglioma-2017","role":"author","urls":{},"keyword":["brain tumor; minimally invasive; neurosurgery; pulsed electric fields; treatment planning"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/network/files/m6LMYYjquH6L2jgcD","dataSources":["ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW"],"keywords":["brain tumor; minimally invasive; neurosurgery; pulsed electric fields; treatment planning"],"search_terms":["predictive","therapeutic","planning","irreversible","electroporation","treatment","spontaneous","malignant","glioma","garcia","kos","rossmeisl","pavliha","miklavcic","davalos"],"title":"Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma","year":2017}