@article{RN167,
   author = {Garcia, P. A. and Kos, B. and Rossmeisl, J. H., Jr. and Pavliha, D. and Miklavčič, D. and Davalos, R. V.},
   title = {Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma},
   journal = {Med Phys},
   volume = {44},
   number = {9},
   pages = {4968-4980},
   note = {2473-4209
Garcia, Paulo A
Kos, Bor
Rossmeisl, John H Jr
Pavliha, Denis
Miklavčič, Damijan
Davalos, Rafael V
Journal Article
United States
2017/06/09
Med Phys. 2017 Sep;44(9):4968-4980. doi: 10.1002/mp.12401. Epub 2017 Jul 25.},
   abstract = {PURPOSE: Irreversible electroporation (IRE) has been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to determine the Peleg-Fermi parameters needed to incorporate pulse number and pulse duration into the therapeutic planning of IRE. METHODS: Seven canine patients were treated with IRE for spontaneous malignant glioma with MRI-based treatment planning. The treatment planning method consists of building patient-specific finite element models and using them to compute electric fields used in the IRE treatment. We evaluate the predictive power of tumor coverage with electric field alone vs. cell kill probability using radiographically confirmed clinical outcomes. RESULTS: Results of post-treatment diagnostic imaging, tumor biopsies, and neurological examinations indicated successful tumor ablation without significant direct neurotoxicity in six of the seven dogs. Objective tumor responses were seen in four (80%) of five dogs with quantifiable target lesions according to RANO criteria. Two dogs experienced survivals in excess of 1 yr, including one dog that resulted in complete response to IRE treatment for 5+ years to date. Tumor fraction exposed to electric field over 600 V/cm was between 0.08 and 0.73, while tumor fraction exposed to electric field over 300 V/cm was between 0.17 and 0.95. Probability of cell kill of ≥ 90% was found in tumor volume fractions between 0.21 and 0.99. CONCLUSIONS: We conclude that IRE is a safe and effective minimally invasive treatment for malignant glioma and can be predicted with the Peleg-Fermi cell kill probability function. A tumor coverage of ≥ 0.9 at a cell kill probability ≥ 90% can be used to guide IRE treatments of spontaneous malignant glioma based on the radiographically confirmed clinical outcomes achieved.},
   keywords = {Animals
Brain Neoplasms/*therapy
Dogs
*Electroporation
Glioma/*therapy
Magnetic Resonance Imaging
Treatment Outcome
brain tumor
minimally invasive
neurosurgery
pulsed electric fields
treatment planning},
   ISSN = {0094-2405},
   DOI = {10.1002/mp.12401},
   year = {2017},
   type = {Journal Article}
}

{"_id":"TH2MnWJHsgKGKhxj6","bibbaseid":"garcia-kos-rossmeisl-pavliha-miklavi-davalos-predictivetherapeuticplanningforirreversibleelectroporationtreatmentofspontaneousmalignantglioma-2017","downloads":0,"creationDate":"2019-03-08T20:39:38.893Z","title":"Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma","author_short":["Garcia, P. A.","Kos, B.","Rossmeisl, J. H.","Pavliha, D.","Miklavčič, D.","Davalos, R. V."],"year":2017,"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Garcia"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Kos"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Rossmeisl"],"firstnames":["J.","H."],"suffixes":["Jr."]},{"propositions":[],"lastnames":["Pavliha"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Miklavčič"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma","journal":"Med Phys","volume":"44","number":"9","pages":"4968-4980","note":"2473-4209 Garcia, Paulo A Kos, Bor Rossmeisl, John H Jr Pavliha, Denis Miklavčič, Damijan Davalos, Rafael V Journal Article United States 2017/06/09 Med Phys. 2017 Sep;44(9):4968-4980. doi: 10.1002/mp.12401. Epub 2017 Jul 25.","abstract":"PURPOSE: Irreversible electroporation (IRE) has been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to determine the Peleg-Fermi parameters needed to incorporate pulse number and pulse duration into the therapeutic planning of IRE. METHODS: Seven canine patients were treated with IRE for spontaneous malignant glioma with MRI-based treatment planning. The treatment planning method consists of building patient-specific finite element models and using them to compute electric fields used in the IRE treatment. We evaluate the predictive power of tumor coverage with electric field alone vs. cell kill probability using radiographically confirmed clinical outcomes. RESULTS: Results of post-treatment diagnostic imaging, tumor biopsies, and neurological examinations indicated successful tumor ablation without significant direct neurotoxicity in six of the seven dogs. Objective tumor responses were seen in four (80%) of five dogs with quantifiable target lesions according to RANO criteria. Two dogs experienced survivals in excess of 1 yr, including one dog that resulted in complete response to IRE treatment for 5+ years to date. Tumor fraction exposed to electric field over 600 V/cm was between 0.08 and 0.73, while tumor fraction exposed to electric field over 300 V/cm was between 0.17 and 0.95. Probability of cell kill of ≥ 90% was found in tumor volume fractions between 0.21 and 0.99. CONCLUSIONS: We conclude that IRE is a safe and effective minimally invasive treatment for malignant glioma and can be predicted with the Peleg-Fermi cell kill probability function. A tumor coverage of ≥ 0.9 at a cell kill probability ≥ 90% can be used to guide IRE treatments of spontaneous malignant glioma based on the radiographically confirmed clinical outcomes achieved.","keywords":"Animals Brain Neoplasms/*therapy Dogs *Electroporation Glioma/*therapy Magnetic Resonance Imaging Treatment Outcome brain tumor minimally invasive neurosurgery pulsed electric fields treatment planning","issn":"0094-2405","doi":"10.1002/mp.12401","year":"2017","bibtex":"@article{RN167,\n author = {Garcia, P. A. and Kos, B. and Rossmeisl, J. H., Jr. and Pavliha, D. and Miklavčič, D. and Davalos, R. V.},\n title = {Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma},\n journal = {Med Phys},\n volume = {44},\n number = {9},\n pages = {4968-4980},\n note = {2473-4209\nGarcia, Paulo A\nKos, Bor\nRossmeisl, John H Jr\nPavliha, Denis\nMiklavčič, Damijan\nDavalos, Rafael V\nJournal Article\nUnited States\n2017/06/09\nMed Phys. 2017 Sep;44(9):4968-4980. doi: 10.1002/mp.12401. Epub 2017 Jul 25.},\n abstract = {PURPOSE: Irreversible electroporation (IRE) has been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to determine the Peleg-Fermi parameters needed to incorporate pulse number and pulse duration into the therapeutic planning of IRE. METHODS: Seven canine patients were treated with IRE for spontaneous malignant glioma with MRI-based treatment planning. The treatment planning method consists of building patient-specific finite element models and using them to compute electric fields used in the IRE treatment. We evaluate the predictive power of tumor coverage with electric field alone vs. cell kill probability using radiographically confirmed clinical outcomes. RESULTS: Results of post-treatment diagnostic imaging, tumor biopsies, and neurological examinations indicated successful tumor ablation without significant direct neurotoxicity in six of the seven dogs. Objective tumor responses were seen in four (80%) of five dogs with quantifiable target lesions according to RANO criteria. Two dogs experienced survivals in excess of 1 yr, including one dog that resulted in complete response to IRE treatment for 5+ years to date. Tumor fraction exposed to electric field over 600 V/cm was between 0.08 and 0.73, while tumor fraction exposed to electric field over 300 V/cm was between 0.17 and 0.95. Probability of cell kill of ≥ 90% was found in tumor volume fractions between 0.21 and 0.99. CONCLUSIONS: We conclude that IRE is a safe and effective minimally invasive treatment for malignant glioma and can be predicted with the Peleg-Fermi cell kill probability function. A tumor coverage of ≥ 0.9 at a cell kill probability ≥ 90% can be used to guide IRE treatments of spontaneous malignant glioma based on the radiographically confirmed clinical outcomes achieved.},\n keywords = {Animals\nBrain Neoplasms/*therapy\nDogs\n*Electroporation\nGlioma/*therapy\nMagnetic Resonance Imaging\nTreatment Outcome\nbrain tumor\nminimally invasive\nneurosurgery\npulsed electric fields\ntreatment planning},\n ISSN = {0094-2405},\n DOI = {10.1002/mp.12401},\n year = {2017},\n type = {Journal Article}\n}\n\n","author_short":["Garcia, P. A.","Kos, B.","Rossmeisl, J. H.","Pavliha, D.","Miklavčič, D.","Davalos, R. 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