Non-thermal irreversible electroporation for deep intracranial disorders. Garcia, P. A., Neal, R. E., Rossmeisl, J. H., & Davalos, R. V. Annu Int Conf IEEE Eng Med Biol Soc, 2010:2743-6, 2010. Garcia, Paulo A Neal, Robert E Rossmeisl, John H Davalos, Rafael V Journal Article United States 2010/11/26 Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2743-6. doi: 10.1109/IEMBS.2010.5626371.
doi  abstract   bibtex   
Non-thermal irreversible electroporation (N-TIRE) is a new minimally invasive technique to kill undesirable tissue. We build on our previous intracranial studies in order to evaluate the possibility of using N-TIRE for deep intracranial disorders. In this manuscript we describe a minimally invasive computed tomography (CT) guided N-TIRE procedure in white matter. In addition, we report the electric field threshold needed for white matter ablation (630 - 875 V/cm) using four sets of twenty 50 µs pulses at a voltage-to-distance ratio of 1000 V/cm. We also confirm the non-thermal aspect of the technique with real time temperature data measured at the electrode-tissue interface.
@article{RN228,
   author = {Garcia, P. A. and Neal, R. E. and Rossmeisl, J. H. and Davalos, R. V.},
   title = {Non-thermal irreversible electroporation for deep intracranial disorders},
   journal = {Annu Int Conf IEEE Eng Med Biol Soc},
   volume = {2010},
   pages = {2743-6},
   note = {Garcia, Paulo A
Neal, Robert E
Rossmeisl, John H
Davalos, Rafael V
Journal Article
United States
2010/11/26
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2743-6. doi: 10.1109/IEMBS.2010.5626371.},
   abstract = {Non-thermal irreversible electroporation (N-TIRE) is a new minimally invasive technique to kill undesirable tissue. We build on our previous intracranial studies in order to evaluate the possibility of using N-TIRE for deep intracranial disorders. In this manuscript we describe a minimally invasive computed tomography (CT) guided N-TIRE procedure in white matter. In addition, we report the electric field threshold needed for white matter ablation (630 - 875 V/cm) using four sets of twenty 50 µs pulses at a voltage-to-distance ratio of 1000 V/cm. We also confirm the non-thermal aspect of the technique with real time temperature data measured at the electrode-tissue interface.},
   keywords = {Algorithms
Animals
Body Temperature
Brain/pathology
Brain Neoplasms/*therapy/veterinary
Catheter Ablation/*methods
Computers
Corpus Callosum/pathology
Dogs
Electrodes
Electroporation/*methods
Medical Oncology/methods
Models, Theoretical
Temperature
Tomography, X-Ray Computed/methods},
   ISSN = {2375-7477 (Print)
2375-7477},
   DOI = {10.1109/iembs.2010.5626371},
   year = {2010},
   type = {Journal Article}
}

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