@article{RN223,
   author = {Garcia, P. A. and Rossmeisl, J. H., Jr. and Neal, R. E., 2nd and Ellis, T. L. and Davalos, R. V.},
   title = {A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure},
   journal = {Biomed Eng Online},
   volume = {10},
   pages = {34},
   note = {1475-925x
Garcia, Paulo A
Rossmeisl, John H Jr
Neal, Robert E 2nd
Ellis, Thomas L
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
England
2011/05/03
Biomed Eng Online. 2011 Apr 30;10:34. doi: 10.1186/1475-925X-10-34.},
   abstract = {BACKGROUND: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedure, the pulse parameters and electrode configuration must be optimized to achieve complete coverage of the targeted tissue while preventing thermal damage due to excessive Joule heating. METHODS: We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure. These models were adapted to assess the effects of temperature, electroporation, pulse duration, and repetition rate on the volumes of tissue undergoing IRE alone or in superposition with thermal damage. RESULTS: Nine different combinations of voltage and pulse frequency were investigated, five of which resulted in IRE alone while four produced IRE in superposition with thermal damage. CONCLUSIONS: The parametric study evaluated the influence of pulse frequency and applied voltage on treatment volumes, and refined a proposed method to delineate IRE from thermal damage. We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment. The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.},
   keywords = {Animals
Brain/*cytology
Dogs
Electric Conductivity
*Electroporation
Hot Temperature/*adverse effects
*Models, Biological
Time Factors},
   ISSN = {1475-925x},
   DOI = {10.1186/1475-925x-10-34},
   year = {2011},
   type = {Journal Article}
}

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V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Garcia"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Rossmeisl"],"firstnames":["J.","H."],"suffixes":["Jr."]},{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Ellis"],"firstnames":["T.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure","journal":"Biomed Eng Online","volume":"10","pages":"34","note":"1475-925x Garcia, Paulo A Rossmeisl, John H Jr Neal, Robert E 2nd Ellis, Thomas L Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. England 2011/05/03 Biomed Eng Online. 2011 Apr 30;10:34. doi: 10.1186/1475-925X-10-34.","abstract":"BACKGROUND: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedure, the pulse parameters and electrode configuration must be optimized to achieve complete coverage of the targeted tissue while preventing thermal damage due to excessive Joule heating. METHODS: We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure. These models were adapted to assess the effects of temperature, electroporation, pulse duration, and repetition rate on the volumes of tissue undergoing IRE alone or in superposition with thermal damage. RESULTS: Nine different combinations of voltage and pulse frequency were investigated, five of which resulted in IRE alone while four produced IRE in superposition with thermal damage. CONCLUSIONS: The parametric study evaluated the influence of pulse frequency and applied voltage on treatment volumes, and refined a proposed method to delineate IRE from thermal damage. We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment. The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.","keywords":"Animals Brain/*cytology Dogs Electric Conductivity *Electroporation Hot Temperature/*adverse effects *Models, Biological Time Factors","issn":"1475-925x","doi":"10.1186/1475-925x-10-34","year":"2011","bibtex":"@article{RN223,\n author = {Garcia, P. A. and Rossmeisl, J. H., Jr. and Neal, R. E., 2nd and Ellis, T. L. and Davalos, R. V.},\n title = {A parametric study delineating irreversible electroporation from thermal damage based on a minimally invasive intracranial procedure},\n journal = {Biomed Eng Online},\n volume = {10},\n pages = {34},\n note = {1475-925x\nGarcia, Paulo A\nRossmeisl, John H Jr\nNeal, Robert E 2nd\nEllis, Thomas L\nDavalos, Rafael V\nJournal Article\nResearch Support, Non-U.S. Gov't\nResearch Support, U.S. Gov't, Non-P.H.S.\nEngland\n2011/05/03\nBiomed Eng Online. 2011 Apr 30;10:34. doi: 10.1186/1475-925X-10-34.},\n abstract = {BACKGROUND: Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedure, the pulse parameters and electrode configuration must be optimized to achieve complete coverage of the targeted tissue while preventing thermal damage due to excessive Joule heating. METHODS: We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure. These models were adapted to assess the effects of temperature, electroporation, pulse duration, and repetition rate on the volumes of tissue undergoing IRE alone or in superposition with thermal damage. RESULTS: Nine different combinations of voltage and pulse frequency were investigated, five of which resulted in IRE alone while four produced IRE in superposition with thermal damage. CONCLUSIONS: The parametric study evaluated the influence of pulse frequency and applied voltage on treatment volumes, and refined a proposed method to delineate IRE from thermal damage. We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment. The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.},\n keywords = {Animals\nBrain/*cytology\nDogs\nElectric Conductivity\n*Electroporation\nHot Temperature/*adverse effects\n*Models, Biological\nTime Factors},\n ISSN = {1475-925x},\n DOI = {10.1186/1475-925x-10-34},\n year = {2011},\n type = {Journal Article}\n}\n\n","author_short":["Garcia, P. A.","Rossmeisl, J. H.","Neal, R. E.","Ellis, T. L.","Davalos, R. 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