@article{RN229,
   author = {Garcia, P. A. and Rossmeisl, J. H., Jr. and Neal, R. E., 2nd and Ellis, T. L. and Olson, J. D. and Henao-Guerrero, N. and Robertson, J. and Davalos, R. V.},
   title = {Intracranial nonthermal irreversible electroporation: in vivo analysis},
   journal = {J Membr Biol},
   volume = {236},
   number = {1},
   pages = {127-36},
   note = {1432-1424
Garcia, Paulo A
Rossmeisl, John H Jr
Neal, Robert E 2nd
Ellis, Thomas L
Olson, John D
Henao-Guerrero, Natalia
Robertson, John
Davalos, Rafael V
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
United States
2010/07/30
J Membr Biol. 2010 Jul;236(1):127-36. doi: 10.1007/s00232-010-9284-z. Epub 2010 Jul 29.},
   abstract = {Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE procedures involve placing electrodes into the targeted area of the brain and delivering a series of short but intense electric pulses. The electric pulses induce irreversible structural changes in cell membranes, leading to cell death. We correlated NTIRE lesion volumes in normal brain tissue with electric field distributions from comprehensive numerical models. The electrical conductivity of brain tissue was extrapolated from the measured in vivo data and the numerical models. Using this, we present results on the electric field threshold necessary to induce NTIRE lesions (495-510 V/cm) in canine brain tissue using 90 50-mus pulses at 4 Hz. Furthermore, this preliminary study provides some of the necessary numerical tools for using NTIRE as a brain cancer treatment. We also computed the electrical conductivity of brain tissue from the in vivo data (0.12-0.30 S/m) and provide guidelines for treatment planning and execution. Knowledge of the dynamic electrical conductivity of the tissue and electric field that correlates to lesion volume is crucial to ensure predictable complete NTIRE treatment while minimizing damage to surrounding healthy tissue.},
   keywords = {Animals
*Brain
Brain Neoplasms/*therapy
Dogs
Electrochemotherapy/instrumentation/*methods
Models, Biological},
   ISSN = {0022-2631},
   DOI = {10.1007/s00232-010-9284-z},
   year = {2010},
   type = {Journal Article}
}

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V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Garcia"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Rossmeisl"],"firstnames":["J.","H."],"suffixes":["Jr."]},{"propositions":[],"lastnames":["Neal"],"firstnames":["R.","E."],"suffixes":["2nd"]},{"propositions":[],"lastnames":["Ellis"],"firstnames":["T.","L."],"suffixes":[]},{"propositions":[],"lastnames":["Olson"],"firstnames":["J.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Henao-Guerrero"],"firstnames":["N."],"suffixes":[]},{"propositions":[],"lastnames":["Robertson"],"firstnames":["J."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Intracranial nonthermal irreversible electroporation: in vivo analysis","journal":"J Membr Biol","volume":"236","number":"1","pages":"127-36","note":"1432-1424 Garcia, Paulo A Rossmeisl, John H Jr Neal, Robert E 2nd Ellis, Thomas L Olson, John D Henao-Guerrero, Natalia Robertson, John Davalos, Rafael V Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. United States 2010/07/30 J Membr Biol. 2010 Jul;236(1):127-36. doi: 10.1007/s00232-010-9284-z. Epub 2010 Jul 29.","abstract":"Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE procedures involve placing electrodes into the targeted area of the brain and delivering a series of short but intense electric pulses. The electric pulses induce irreversible structural changes in cell membranes, leading to cell death. We correlated NTIRE lesion volumes in normal brain tissue with electric field distributions from comprehensive numerical models. The electrical conductivity of brain tissue was extrapolated from the measured in vivo data and the numerical models. Using this, we present results on the electric field threshold necessary to induce NTIRE lesions (495-510 V/cm) in canine brain tissue using 90 50-mus pulses at 4 Hz. Furthermore, this preliminary study provides some of the necessary numerical tools for using NTIRE as a brain cancer treatment. We also computed the electrical conductivity of brain tissue from the in vivo data (0.12-0.30 S/m) and provide guidelines for treatment planning and execution. Knowledge of the dynamic electrical conductivity of the tissue and electric field that correlates to lesion volume is crucial to ensure predictable complete NTIRE treatment while minimizing damage to surrounding healthy tissue.","keywords":"Animals *Brain Brain Neoplasms/*therapy Dogs Electrochemotherapy/instrumentation/*methods Models, Biological","issn":"0022-2631","doi":"10.1007/s00232-010-9284-z","year":"2010","bibtex":"@article{RN229,\n author = {Garcia, P. A. and Rossmeisl, J. H., Jr. and Neal, R. E., 2nd and Ellis, T. L. and Olson, J. D. and Henao-Guerrero, N. and Robertson, J. and Davalos, R. V.},\n title = {Intracranial nonthermal irreversible electroporation: in vivo analysis},\n journal = {J Membr Biol},\n volume = {236},\n number = {1},\n pages = {127-36},\n note = {1432-1424\nGarcia, Paulo A\nRossmeisl, John H Jr\nNeal, Robert E 2nd\nEllis, Thomas L\nOlson, John D\nHenao-Guerrero, Natalia\nRobertson, John\nDavalos, Rafael V\nJournal Article\nResearch Support, Non-U.S. Gov't\nResearch Support, U.S. Gov't, Non-P.H.S.\nUnited States\n2010/07/30\nJ Membr Biol. 2010 Jul;236(1):127-36. doi: 10.1007/s00232-010-9284-z. Epub 2010 Jul 29.},\n abstract = {Nonthermal irreversible electroporation (NTIRE) is a new minimally invasive technique to treat cancer. It is unique because of its nonthermal mechanism of tumor ablation. Intracranial NTIRE procedures involve placing electrodes into the targeted area of the brain and delivering a series of short but intense electric pulses. The electric pulses induce irreversible structural changes in cell membranes, leading to cell death. We correlated NTIRE lesion volumes in normal brain tissue with electric field distributions from comprehensive numerical models. The electrical conductivity of brain tissue was extrapolated from the measured in vivo data and the numerical models. Using this, we present results on the electric field threshold necessary to induce NTIRE lesions (495-510 V/cm) in canine brain tissue using 90 50-mus pulses at 4 Hz. Furthermore, this preliminary study provides some of the necessary numerical tools for using NTIRE as a brain cancer treatment. We also computed the electrical conductivity of brain tissue from the in vivo data (0.12-0.30 S/m) and provide guidelines for treatment planning and execution. Knowledge of the dynamic electrical conductivity of the tissue and electric field that correlates to lesion volume is crucial to ensure predictable complete NTIRE treatment while minimizing damage to surrounding healthy tissue.},\n keywords = {Animals\n*Brain\nBrain Neoplasms/*therapy\nDogs\nElectrochemotherapy/instrumentation/*methods\nModels, Biological},\n ISSN = {0022-2631},\n DOI = {10.1007/s00232-010-9284-z},\n year = {2010},\n type = {Journal Article}\n}\n\n","author_short":["Garcia, P. A.","Rossmeisl, J. H.","Neal, R. E.","Ellis, T. L.","Olson, J. D.","Henao-Guerrero, N.","Robertson, J.","Davalos, R. 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