Anatomic Characterization of Prelemniscal Radiations by Probabilistic Tractography: Implications in Parkinson's Disease.

Anatomic Characterization of Prelemniscal Radiations by Probabilistic Tractography: Implications in Parkinson's Disease. . García-Gomar, M.., Soto-Abraham, J., Velasco-Campos, F., & Concha, L. Brain Struct Funct, 222(1):71–81, January, 2017.
doi abstract bibtex

To characterize the anatomical connectivity of the prelemniscal radiations (Raprl), a white matter region within the posterior subthalamic area (PSA) that is an effective neurosurgical target for treating motor symptoms of Parkinson's disease (PD). Diffusion-weighted images were acquired from twelve healthy subjects using a 3T scanner. Constrained spherical deconvolution, a method that allows the distinction of crossing fibers within a voxel, was used to compute track-density images with sufficient resolution to accurately delineate distinct PSA regions and probabilistic tractography of Raprl in both hemispheres. Raprl connectivity was reproducible across all subjects and showed fibers traversing through this region towards primary and supplementary motor cortices, the orbitofrontal cortex, ventrolateral thalamus, and the globus pallidus, cerebellum and dorsal brainstem. All brain regions reached by Raprl fibers are part of motor circuits involved in the pathophysiology of PD; while these fiber systems converge at the level of the PSA, they can be spatially segregated. Fibers of distinct and specific motor control networks are identified within Raprl. The description of this anatomical crossroad suggests that, in the future, tractography could allow deep brain stimulation or lesional therapies in white matter targets according to individual patient's symptoms.

@article{garca-gomar2017anatomic,
	title        = {
		Anatomic Characterization of Prelemniscal Radiations by Probabilistic
		Tractography: Implications in {{Parkinson}}'s Disease.
	},
	author       = {
		{Garc{\'i}a-Gomar}, M.. and {Soto-Abraham}, Julian and {Velasco-Campos},
		Francisco and Concha, Luis
	},
	year         = 2017,
	month        = jan,
	journal      = {Brain Struct Funct},
	volume       = 222,
	number       = 1,
	pages        = {71--81},
	doi          = {10.1007/s00429-016-1201-5},
	copyright    = {All rights reserved},
	institution  = {
		Instituto de Neurobiolog{\'i}a, Universidad Nacional Aut{\'o}noma de
		M{\'e}xico, Quer{\'e}taro, M{\'e}xico. lconcha\@unam.mx.
	},
	__markedentry = {[lconcha:6]},
	abstract     = {
		To characterize the anatomical connectivity of the prelemniscal radiations
		(Raprl), a white matter region within the posterior subthalamic area (PSA)
		that is an effective neurosurgical target for treating motor symptoms of
		Parkinson's disease (PD). Diffusion-weighted images were acquired from twelve
		healthy subjects using a 3T scanner. Constrained spherical deconvolution, a
		method that allows the distinction of crossing fibers within a voxel, was
		used to compute track-density images with sufficient resolution to accurately
		delineate distinct PSA regions and probabilistic tractography of Raprl in
		both hemispheres. Raprl connectivity was reproducible across all subjects and
		showed fibers traversing through this region towards primary and
		supplementary motor cortices, the orbitofrontal cortex, ventrolateral
		thalamus, and the globus pallidus, cerebellum and dorsal brainstem. All brain
		regions reached by Raprl fibers are part of motor circuits involved in the
		pathophysiology of PD; while these fiber systems converge at the level of the
		PSA, they can be spatially segregated. Fibers of distinct and specific motor
		control networks are identified within Raprl. The description of this
		anatomical crossroad suggests that, in the future, tractography could allow
		deep brain stimulation or lesional therapies in white matter targets
		according to individual patient's symptoms.
	},
	langid       = {english},
	medline-pst  = {aheadofprint},
	owner        = {lconcha},
	pii          = {10.1007/s00429-016-1201-5},
	pmid         = 26902343,
	timestamp    = {2016.05.16}
}

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","author":[{"firstnames":[],"propositions":[],"lastnames":["García-Gomar, M.."],"suffixes":[]},{"propositions":[],"lastnames":["Soto-Abraham"],"firstnames":["Julian"],"suffixes":[]},{"propositions":[],"lastnames":["Velasco-Campos"],"firstnames":["Francisco"],"suffixes":[]},{"propositions":[],"lastnames":["Concha"],"firstnames":["Luis"],"suffixes":[]}],"year":"2017","month":"January","journal":"Brain Struct Funct","volume":"222","number":"1","pages":"71–81","doi":"10.1007/s00429-016-1201-5","copyright":"All rights reserved","institution":"Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México. lconcha\\@unam.mx. ","__markedentry":"[lconcha:6]","abstract":"To characterize the anatomical connectivity of the prelemniscal radiations (Raprl), a white matter region within the posterior subthalamic area (PSA) that is an effective neurosurgical target for treating motor symptoms of Parkinson's disease (PD). 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