@article{RN107,
   author = {Garcia Mora, J. K. and Robertson, J. and Hsu, F. C. and Shinn, R. L. and Larson, M. M. and Rylander, C. G. and Whitlow, C. T. and Debinski, W. and Davalos, R. V. and G, B. Daniel and Rossmeisl, J. H.},
   title = {Comparison of linear and volumetric criteria for the determination of therapeutic response in dogs with intracranial gliomas},
   journal = {J Vet Intern Med},
   volume = {36},
   number = {3},
   pages = {1066-1074},
   note = {1939-1676
Garcia Mora, Josefa Karina
Robertson, John
Hsu, Fang-Chi
Shinn, Richard Levon
Orcid: 0000-0003-4308-4374
Larson, Martha M
Rylander, Christopher G
Whitlow, Christopher T
Debinski, Waldemar
Davalos, Rafael V
B Daniel, Gregory
Rossmeisl, John H
Orcid: 0000-0003-1655-7076
P01CA207206/CA/NCI NIH HHS/United States
R01 CA213423/CA/NCI NIH HHS/United States
R01CA213423/CA/NCI NIH HHS/United States
NH/NIH HHS/United States
United States Department of Health and Human Services/
P01 CA207206/CA/NCI NIH HHS/United States
Comparative Study
Journal Article
United States
2022/03/12
J Vet Intern Med. 2022 May;36(3):1066-1074. doi: 10.1111/jvim.16406. Epub 2022 Mar 11.},
   abstract = {BACKGROUND: Brain tumor therapeutic responses can be quantified from magnetic resonance images (MRI) using 1- (1D) and 2-dimensional (2D) linear and volumetric methods, but few studies in dogs compare these techniques. HYPOTHESES: Linear methods will be obtained faster, but have less agreement than volumetric measurements. Therapeutic response agreement will be highest with the total T2W tumor volumetric (TTV) method. Therapeutic response at 6-weeks will correlate with overall survival (OS). ANIMALS: Forty-six dogs with intracranial gliomas. METHODS: Prospective study. Three raters measured tumors using 1D and 2D linear, TTV, and contrast-enhancing volumetric (CEV) techniques on 143 brain MRI to determine agreement between methods, define therapeutic responses, and assess relations with OS. RESULTS: Raters performed 1D the fastest (2.9 ± 0.57 minutes) and CEV slowest (17.8 ± 6.2 minutes). Inter- and intraobserver agreements were excellent (intraclass correlations ≥.91) across methods. Correlations between linear (1D vs 2D; ρ > .91) and volumetric (TTV vs CEV; ρ > .73) methods were stronger than linear to volumetric comparisons (ρ range, .26-.59). Incorporating clinical and imaging data resulted in fewer discordant therapeutic responses across methods. Dogs having partial tumor responses at 6 weeks had a lower death hazard than dogs with stable or progressive disease when assessed using 2D, CEV, and TTV (hazard ration 2.1; 95% confidence interval, 1.22-3.63; P = .008). CONCLUSIONS AND CLINICAL IMPORTANCE: One-dimensional, 2D, CEV, and TTV are comparable for determining therapeutic response. Given the simplicity, universal applicability, and superior performance of the TTV, we recommend its use to standardize glioma therapeutic response criteria.},
   keywords = {Animals
Brain Neoplasms/diagnostic imaging/drug therapy/*veterinary
Dog Diseases/*diagnostic imaging/drug therapy
Dogs
Glioma/diagnostic imaging/drug therapy/*veterinary
Magnetic Resonance Imaging/veterinary
Prospective Studies
Treatment Outcome
dog
magnetic resonance imaging
neurooncology
neuroradiology
radiology and diagnostic imaging},
   ISSN = {0891-6640 (Print)
0891-6640},
   DOI = {10.1111/jvim.16406},
   year = {2022},
   type = {Journal Article}
}