@article{garcia-planella_serial_2018,
	title = {Serial semi-quantitative measurement of fecal calprotectin in patients with ulcerative colitis in remission},
	volume = {53},
	issn = {1502-7708},
	doi = {10.1080/00365521.2017.1410219},
	abstract = {BACKGROUND: Fecal calprotectin (FC) correlates with clinical and endoscopic activity in ulcerative colitis (UC), and it is a good predictor of relapse. However, its use in clinical practice is constrained by the need for the patient to deliver stool samples, and for their handling and processing in the laboratory. The availability of hand held devices might spread the use of FC in clinical practice.
OBJECTIVES: To evaluate the usefulness of a rapid semi-quantitative test of FC in predicting relapse in patients with UC in remission.
MATERIALS AND METHODS: Prospective, multicenter study that included UC patients in clinical remission for ≥6 months on maintenance treatment with mesalamine. Patients were evaluated clinically and semi-quantitative FC was measured using a monoclonal immunochromatography rapid test at baseline and every three months until relapse or 12 months of follow-up.
RESULTS: One hundred and ninety-one patients had at least one determination of FC. At the end of follow-up, 33 patients (17\%) experienced clinical relapse. Endoscopic activity at baseline (p = .043) and having had at least one FC {\textgreater} 60 μg/g during the study period (p = .03) were associated with a higher risk of relapse during follow-up. We obtained a total of 636 semi-quantitative FC determinations matched with a three-month follow-up clinical assessment. Having undetectable FC was inversely associated with early relapse (within three months), with a negative predictive value of 98.6\% and a sensitivity of 93.9\%.
CONCLUSIONS: Serial, rapid semi-quantitative measurement of FC may be a useful, easy and cheap monitoring tool for patients with UC in remission.},
	language = {eng},
	number = {2},
	journal = {Scandinavian Journal of Gastroenterology},
	author = {Garcia-Planella, Esther and Mañosa, Míriam and Chaparro, María and Beltrán, Belén and Barreiro-de-Acosta, Manuel and Gordillo, Jordi and Ricart, Elena and Bermejo, Fernando and García-Sánchez, Valle and Piqueras, Marta and Llaó, Jordina and Gisbert, Javier P. and Cabré, Eduard and Domènech, Eugeni and {PRECUCAL study group Investigators}},
	year = {2018},
	pmid = {29189092},
	keywords = {Article, Digestiu, Fecal calprotectin, relapse, remission, semi-quantitative, ulcerative colitis},
	pages = {152--157},
}

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P.","Cabré, E.","Domènech, E.","PRECUCAL study group Investigators"],"year":2018,"bibtype":"article","biburl":"https://bibbase.org/zotero/Bibliotecacst","bibdata":{"bibtype":"article","type":"article","title":"Serial semi-quantitative measurement of fecal calprotectin in patients with ulcerative colitis in remission","volume":"53","issn":"1502-7708","doi":"10.1080/00365521.2017.1410219","abstract":"BACKGROUND: Fecal calprotectin (FC) correlates with clinical and endoscopic activity in ulcerative colitis (UC), and it is a good predictor of relapse. However, its use in clinical practice is constrained by the need for the patient to deliver stool samples, and for their handling and processing in the laboratory. The availability of hand held devices might spread the use of FC in clinical practice. OBJECTIVES: To evaluate the usefulness of a rapid semi-quantitative test of FC in predicting relapse in patients with UC in remission. MATERIALS AND METHODS: Prospective, multicenter study that included UC patients in clinical remission for ≥6 months on maintenance treatment with mesalamine. Patients were evaluated clinically and semi-quantitative FC was measured using a monoclonal immunochromatography rapid test at baseline and every three months until relapse or 12 months of follow-up. RESULTS: One hundred and ninety-one patients had at least one determination of FC. At the end of follow-up, 33 patients (17%) experienced clinical relapse. Endoscopic activity at baseline (p = .043) and having had at least one FC \\textgreater 60 μg/g during the study period (p = .03) were associated with a higher risk of relapse during follow-up. We obtained a total of 636 semi-quantitative FC determinations matched with a three-month follow-up clinical assessment. Having undetectable FC was inversely associated with early relapse (within three months), with a negative predictive value of 98.6% and a sensitivity of 93.9%. CONCLUSIONS: Serial, rapid semi-quantitative measurement of FC may be a useful, easy and cheap monitoring tool for patients with UC in remission.","language":"eng","number":"2","journal":"Scandinavian Journal of Gastroenterology","author":[{"propositions":[],"lastnames":["Garcia-Planella"],"firstnames":["Esther"],"suffixes":[]},{"propositions":[],"lastnames":["Mañosa"],"firstnames":["Míriam"],"suffixes":[]},{"propositions":[],"lastnames":["Chaparro"],"firstnames":["María"],"suffixes":[]},{"propositions":[],"lastnames":["Beltrán"],"firstnames":["Belén"],"suffixes":[]},{"propositions":[],"lastnames":["Barreiro-de-Acosta"],"firstnames":["Manuel"],"suffixes":[]},{"propositions":[],"lastnames":["Gordillo"],"firstnames":["Jordi"],"suffixes":[]},{"propositions":[],"lastnames":["Ricart"],"firstnames":["Elena"],"suffixes":[]},{"propositions":[],"lastnames":["Bermejo"],"firstnames":["Fernando"],"suffixes":[]},{"propositions":[],"lastnames":["García-Sánchez"],"firstnames":["Valle"],"suffixes":[]},{"propositions":[],"lastnames":["Piqueras"],"firstnames":["Marta"],"suffixes":[]},{"propositions":[],"lastnames":["Llaó"],"firstnames":["Jordina"],"suffixes":[]},{"propositions":[],"lastnames":["Gisbert"],"firstnames":["Javier","P."],"suffixes":[]},{"propositions":[],"lastnames":["Cabré"],"firstnames":["Eduard"],"suffixes":[]},{"propositions":[],"lastnames":["Domènech"],"firstnames":["Eugeni"],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["PRECUCAL study group Investigators"],"suffixes":[]}],"year":"2018","pmid":"29189092","keywords":"Article, Digestiu, Fecal calprotectin, relapse, remission, semi-quantitative, ulcerative colitis","pages":"152–157","bibtex":"@article{garcia-planella_serial_2018,\n\ttitle = {Serial semi-quantitative measurement of fecal calprotectin in patients with ulcerative colitis in remission},\n\tvolume = {53},\n\tissn = {1502-7708},\n\tdoi = {10.1080/00365521.2017.1410219},\n\tabstract = {BACKGROUND: Fecal calprotectin (FC) correlates with clinical and endoscopic activity in ulcerative colitis (UC), and it is a good predictor of relapse. However, its use in clinical practice is constrained by the need for the patient to deliver stool samples, and for their handling and processing in the laboratory. The availability of hand held devices might spread the use of FC in clinical practice.\nOBJECTIVES: To evaluate the usefulness of a rapid semi-quantitative test of FC in predicting relapse in patients with UC in remission.\nMATERIALS AND METHODS: Prospective, multicenter study that included UC patients in clinical remission for ≥6 months on maintenance treatment with mesalamine. Patients were evaluated clinically and semi-quantitative FC was measured using a monoclonal immunochromatography rapid test at baseline and every three months until relapse or 12 months of follow-up.\nRESULTS: One hundred and ninety-one patients had at least one determination of FC. At the end of follow-up, 33 patients (17\\%) experienced clinical relapse. Endoscopic activity at baseline (p = .043) and having had at least one FC {\\textgreater} 60 μg/g during the study period (p = .03) were associated with a higher risk of relapse during follow-up. We obtained a total of 636 semi-quantitative FC determinations matched with a three-month follow-up clinical assessment. Having undetectable FC was inversely associated with early relapse (within three months), with a negative predictive value of 98.6\\% and a sensitivity of 93.9\\%.\nCONCLUSIONS: Serial, rapid semi-quantitative measurement of FC may be a useful, easy and cheap monitoring tool for patients with UC in remission.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Scandinavian Journal of Gastroenterology},\n\tauthor = {Garcia-Planella, Esther and Mañosa, Míriam and Chaparro, María and Beltrán, Belén and Barreiro-de-Acosta, Manuel and Gordillo, Jordi and Ricart, Elena and Bermejo, Fernando and García-Sánchez, Valle and Piqueras, Marta and Llaó, Jordina and Gisbert, Javier P. and Cabré, Eduard and Domènech, Eugeni and {PRECUCAL study group Investigators}},\n\tyear = {2018},\n\tpmid = {29189092},\n\tkeywords = {Article, Digestiu, Fecal calprotectin, relapse, remission, semi-quantitative, ulcerative colitis},\n\tpages = {152--157},\n}\n\n","author_short":["Garcia-Planella, E.","Mañosa, M.","Chaparro, M.","Beltrán, B.","Barreiro-de-Acosta, M.","Gordillo, J.","Ricart, E.","Bermejo, F.","García-Sánchez, V.","Piqueras, M.","Llaó, J.","Gisbert, J. 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