Clinical characterization and antimicrobial resistance of Escherichia coli in pediatric patients with urinary tract infection at a third level hospital of Quito, Ecuador. Garrido, D., Garrido, S., Gutiérrez, M., Calvopiña, L., Harrison, A., Fuseau, M., & Salazar Irigoyen, R. Boletin Medico del Hospital Infantil de Mexico, 74(4):265–271, 2017. Publisher: Masson-Doyma Mexico, S.A.![Clinical characterization and antimicrobial resistance of Escherichia coli in pediatric patients with urinary tract infection at a third level hospital of Quito, Ecuador [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Urinary tract infections (UTI) are among the most common infections in pediatric patients. The main etiopathogenic agent is Escherichia coli. The purpose of this study was to determine the antimicrobial resistance pattern of E. coli in pediatric patients and to understand their main clinical and laboratory manifestations. Methods Fifty-nine patients were included in the study and classified into two groups: hospitalization (H) and external consultation (EC). Every patient presented urine cultures with the isolation of E. coli that included an antibiogram. Clinical signs and symptoms, urinalysis, complete blood count (CBC) and serum inflammatory markers were analyzed. Results The most common clinical manifestations were fever (H: 76.5%; EC: 88%), vomiting (H: 32.4%; EC: 32%), hyporexia (H: 20.6%; EC: 16%), abdominal pain (H: 20.6%: EC: 28%), and dysuria (H: 14.7%; EC: 32%). Ten patients (16.95%) presented UTI for extended spectrum beta-lactamase (ESBL) E. coli. Ampicillin, nalidixic acid, and trimethoprim-sulfamethoxazole showed a higher resistance rate, being ampicillin the most significant (H: 88.2%; EC: 92%). Leukocyturia, bacteriuria and urine nitrites were frequent alterations in urinalysis (H: 52.9%; EC: 92%). In ESBL E. coli patients, a positive correlation was found between leukocytes in CBC and C-reactive protein (r = 0.9, p \textless 0.01). Diarrhea and foul-smelling urine were associated with E. coli resistance. Conclusions The presence of leukocytes, bacteria, nitrites and the Gram stain are the most common indicators. Nitrofurantoin and phosphomycin are good therapeutic options. However, an antibiogram must be conducted to determine the best therapeutic agent. © 2017 Hospital Infantil de México Federico Gómez
@article{garrido_clinical_2017,
title = {Clinical characterization and antimicrobial resistance of {Escherichia} coli in pediatric patients with urinary tract infection at a third level hospital of {Quito}, {Ecuador}},
volume = {74},
issn = {16651146 (ISSN)},
shorttitle = {Caracterización clínica y resistencia antimicrobiana de {Escherichia} coli en pacientes pediátricos con infección del tracto urinario en un hospital de tercer nivel en {Quito}, {Ecuador}},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021907618&doi=10.1016%2fj.bmhimx.2017.02.004&partnerID=40&md5=28f61a17046876ebe853b5b6842a173d},
doi = {10.1016/j.bmhimx.2017.02.004},
abstract = {Background Urinary tract infections (UTI) are among the most common infections in pediatric patients. The main etiopathogenic agent is Escherichia coli. The purpose of this study was to determine the antimicrobial resistance pattern of E. coli in pediatric patients and to understand their main clinical and laboratory manifestations. Methods Fifty-nine patients were included in the study and classified into two groups: hospitalization (H) and external consultation (EC). Every patient presented urine cultures with the isolation of E. coli that included an antibiogram. Clinical signs and symptoms, urinalysis, complete blood count (CBC) and serum inflammatory markers were analyzed. Results The most common clinical manifestations were fever (H: 76.5\%; EC: 88\%), vomiting (H: 32.4\%; EC: 32\%), hyporexia (H: 20.6\%; EC: 16\%), abdominal pain (H: 20.6\%: EC: 28\%), and dysuria (H: 14.7\%; EC: 32\%). Ten patients (16.95\%) presented UTI for extended spectrum beta-lactamase (ESBL) E. coli. Ampicillin, nalidixic acid, and trimethoprim-sulfamethoxazole showed a higher resistance rate, being ampicillin the most significant (H: 88.2\%; EC: 92\%). Leukocyturia, bacteriuria and urine nitrites were frequent alterations in urinalysis (H: 52.9\%; EC: 92\%). In ESBL E. coli patients, a positive correlation was found between leukocytes in CBC and C-reactive protein (r = 0.9, p {\textless} 0.01). Diarrhea and foul-smelling urine were associated with E. coli resistance. Conclusions The presence of leukocytes, bacteria, nitrites and the Gram stain are the most common indicators. Nitrofurantoin and phosphomycin are good therapeutic options. However, an antibiogram must be conducted to determine the best therapeutic agent. © 2017 Hospital Infantil de México Federico Gómez},
language = {English; Spanish},
number = {4},
journal = {Boletin Medico del Hospital Infantil de Mexico},
author = {Garrido, D. and Garrido, S. and Gutiérrez, M. and Calvopiña, L. and Harrison, A.S. and Fuseau, M. and Salazar Irigoyen, R.},
year = {2017},
note = {Publisher: Masson-Doyma Mexico, S.A.},
keywords = {Adolescent, Anti-Bacterial Agents, Article, Bacteriuria, Blood Cell Count, C reactive protein, Child, Child, Preschool, Drug Resistance, Bacterial, Ecuador, Escherichia coli, Escherichia coli Infections, Escherichia coli infection, Female, Hospitals, Humans, Infant, Male, Microbial Sensitivity Tests, Pediatrics, Tertiary Care Centers, Urinary Tract Infections, Urinary tract infections, abdominal pain, adolescent, ampicillin, antibiotic resistance, antibiotic sensitivity, antiinfective agent, antimicrobial therapy, bacteriuria, beta lactamase inhibitor, blood cell count, cefazolin, cefepime, ceftriaxone, cefuroxime, cephalosporin, child, clavulanic acid, convulsion, cotrimoxazole, coughing, diarrhea, disk diffusion, drug effect, dysuria, erythrocyte sedimentation rate, extended spectrum beta lactamase, eyelid edema, female, fever, fosfomycin, genital erythema, gentamicin, headache, hematuria, hospital, hospitalization, human, imipenem, infant, irritability, isolation and purification, leukocyturia, levofloxacin, low back pain, major clinical study, male, microbial sensitivity test, microbiology, micturition, minimum inhibitory concentration, nalidixic acid, nitrofurantoin, observational study, pathophysiology, petechia, piperacillin plus tazobactam, pollakisuria, preschool child, sultamicillin, tertiary care center, ureidopenicillin, urinalysis, urinary tract infection, urinary urgency, urine culture, urine odor, vomiting},
pages = {265--271},
}
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The main etiopathogenic agent is Escherichia coli. The purpose of this study was to determine the antimicrobial resistance pattern of E. coli in pediatric patients and to understand their main clinical and laboratory manifestations. Methods Fifty-nine patients were included in the study and classified into two groups: hospitalization (H) and external consultation (EC). Every patient presented urine cultures with the isolation of E. coli that included an antibiogram. Clinical signs and symptoms, urinalysis, complete blood count (CBC) and serum inflammatory markers were analyzed. Results The most common clinical manifestations were fever (H: 76.5%; EC: 88%), vomiting (H: 32.4%; EC: 32%), hyporexia (H: 20.6%; EC: 16%), abdominal pain (H: 20.6%: EC: 28%), and dysuria (H: 14.7%; EC: 32%). Ten patients (16.95%) presented UTI for extended spectrum beta-lactamase (ESBL) E. coli. Ampicillin, nalidixic acid, and trimethoprim-sulfamethoxazole showed a higher resistance rate, being ampicillin the most significant (H: 88.2%; EC: 92%). Leukocyturia, bacteriuria and urine nitrites were frequent alterations in urinalysis (H: 52.9%; EC: 92%). In ESBL E. coli patients, a positive correlation was found between leukocytes in CBC and C-reactive protein (r = 0.9, p \\textless 0.01). Diarrhea and foul-smelling urine were associated with E. coli resistance. Conclusions The presence of leukocytes, bacteria, nitrites and the Gram stain are the most common indicators. Nitrofurantoin and phosphomycin are good therapeutic options. However, an antibiogram must be conducted to determine the best therapeutic agent. © 2017 Hospital Infantil de México Federico Gómez","language":"English; Spanish","number":"4","journal":"Boletin Medico del Hospital Infantil de Mexico","author":[{"propositions":[],"lastnames":["Garrido"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Garrido"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Gutiérrez"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Calvopiña"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Harrison"],"firstnames":["A.S."],"suffixes":[]},{"propositions":[],"lastnames":["Fuseau"],"firstnames":["M."],"suffixes":[]},{"propositions":[],"lastnames":["Salazar","Irigoyen"],"firstnames":["R."],"suffixes":[]}],"year":"2017","note":"Publisher: Masson-Doyma Mexico, S.A.","keywords":"Adolescent, Anti-Bacterial Agents, Article, Bacteriuria, Blood Cell Count, C reactive protein, Child, Child, Preschool, Drug Resistance, Bacterial, Ecuador, Escherichia coli, Escherichia coli Infections, Escherichia coli infection, Female, Hospitals, Humans, Infant, Male, Microbial Sensitivity Tests, Pediatrics, Tertiary Care Centers, Urinary Tract Infections, Urinary tract infections, abdominal pain, adolescent, ampicillin, antibiotic resistance, antibiotic sensitivity, antiinfective agent, antimicrobial therapy, bacteriuria, beta lactamase inhibitor, blood cell count, cefazolin, cefepime, ceftriaxone, cefuroxime, cephalosporin, child, clavulanic acid, convulsion, cotrimoxazole, coughing, diarrhea, disk diffusion, drug effect, dysuria, erythrocyte sedimentation rate, extended spectrum beta lactamase, eyelid edema, female, fever, fosfomycin, genital erythema, gentamicin, headache, hematuria, hospital, hospitalization, human, imipenem, infant, irritability, isolation and purification, leukocyturia, levofloxacin, low back pain, major clinical study, male, microbial sensitivity test, microbiology, micturition, minimum inhibitory concentration, nalidixic acid, nitrofurantoin, observational study, pathophysiology, petechia, piperacillin plus tazobactam, pollakisuria, preschool child, sultamicillin, tertiary care center, ureidopenicillin, urinalysis, urinary tract infection, urinary urgency, urine culture, urine odor, vomiting","pages":"265–271","bibtex":"@article{garrido_clinical_2017,\n\ttitle = {Clinical characterization and antimicrobial resistance of {Escherichia} coli in pediatric patients with urinary tract infection at a third level hospital of {Quito}, {Ecuador}},\n\tvolume = {74},\n\tissn = {16651146 (ISSN)},\n\tshorttitle = {Caracterización clínica y resistencia antimicrobiana de {Escherichia} coli en pacientes pediátricos con infección del tracto urinario en un hospital de tercer nivel en {Quito}, {Ecuador}},\n\turl = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021907618&doi=10.1016%2fj.bmhimx.2017.02.004&partnerID=40&md5=28f61a17046876ebe853b5b6842a173d},\n\tdoi = {10.1016/j.bmhimx.2017.02.004},\n\tabstract = {Background Urinary tract infections (UTI) are among the most common infections in pediatric patients. The main etiopathogenic agent is Escherichia coli. The purpose of this study was to determine the antimicrobial resistance pattern of E. coli in pediatric patients and to understand their main clinical and laboratory manifestations. Methods Fifty-nine patients were included in the study and classified into two groups: hospitalization (H) and external consultation (EC). Every patient presented urine cultures with the isolation of E. coli that included an antibiogram. Clinical signs and symptoms, urinalysis, complete blood count (CBC) and serum inflammatory markers were analyzed. Results The most common clinical manifestations were fever (H: 76.5\\%; EC: 88\\%), vomiting (H: 32.4\\%; EC: 32\\%), hyporexia (H: 20.6\\%; EC: 16\\%), abdominal pain (H: 20.6\\%: EC: 28\\%), and dysuria (H: 14.7\\%; EC: 32\\%). Ten patients (16.95\\%) presented UTI for extended spectrum beta-lactamase (ESBL) E. coli. Ampicillin, nalidixic acid, and trimethoprim-sulfamethoxazole showed a higher resistance rate, being ampicillin the most significant (H: 88.2\\%; EC: 92\\%). Leukocyturia, bacteriuria and urine nitrites were frequent alterations in urinalysis (H: 52.9\\%; EC: 92\\%). In ESBL E. coli patients, a positive correlation was found between leukocytes in CBC and C-reactive protein (r = 0.9, p {\\textless} 0.01). Diarrhea and foul-smelling urine were associated with E. coli resistance. Conclusions The presence of leukocytes, bacteria, nitrites and the Gram stain are the most common indicators. Nitrofurantoin and phosphomycin are good therapeutic options. However, an antibiogram must be conducted to determine the best therapeutic agent. © 2017 Hospital Infantil de México Federico Gómez},\n\tlanguage = {English; Spanish},\n\tnumber = {4},\n\tjournal = {Boletin Medico del Hospital Infantil de Mexico},\n\tauthor = {Garrido, D. and Garrido, S. and Gutiérrez, M. and Calvopiña, L. and Harrison, A.S. and Fuseau, M. and Salazar Irigoyen, R.},\n\tyear = {2017},\n\tnote = {Publisher: Masson-Doyma Mexico, S.A.},\n\tkeywords = {Adolescent, Anti-Bacterial Agents, Article, Bacteriuria, Blood Cell Count, C reactive protein, Child, Child, Preschool, Drug Resistance, Bacterial, Ecuador, Escherichia coli, Escherichia coli Infections, Escherichia coli infection, Female, Hospitals, Humans, Infant, Male, Microbial Sensitivity Tests, Pediatrics, Tertiary Care Centers, Urinary Tract Infections, Urinary tract infections, abdominal pain, adolescent, ampicillin, antibiotic resistance, antibiotic sensitivity, antiinfective agent, antimicrobial therapy, 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