Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. Gaynor, J., Kim, D., Arrington, C., Atz, A., Bellinger, D., Burt, A., Ghanayem, N., Jacobs, J., Lee, T., Lewis, A., Mahle, W., Marino, B., Miller, S., Newburger, J., Pizarro, C, Ravishankar, C, Santani, A., Wilder, N., Jarvik, G., Mital, S, & Russell, M. J Thorac Cardiovasc Surg, 148(6):2560–2566, December, 2014. ![Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants. [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OBJECTIVE: Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. The APOE ε2 allele has been associated with worse neurodevelopmental (ND) outcome after repair of congenital heart defects (CHD) in infancy. Replication of this finding in an independent cohort is essential to validate the observed genotype-phenotype association. METHODS: The association of APOE genotype with ND outcomes was assessed in a combined cohort of patients with single-ventricle CHD enrolled in the Single Ventricle Reconstruction and Infant Single Ventricle trials. ND outcome was assessed at 14 months using the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Development-II. Stepwise multivariable regression was performed to develop predictive models for PDI and MDI scores. RESULTS: Complete data were available for 298 of 435 patients. After adjustment for preoperative and postoperative covariates, the APOE ε2 allele was associated with a lower PDI score (P = .038). Patients with the ε2 allele had a PDI score approximately 6 points lower than those without the risk allele, explaining 1.04% of overall PDI variance, because the ε2 allele was present in only 11% of the patients. There was a marginal effect of the ε2 allele on MDI scores (P = .058). CONCLUSIONS: These data validate the association of the APOE ε2 allele with adverse early ND outcomes after cardiac surgery in infants, independent of patient and operative factors. Genetic variants that decrease neuroresilience and impair neuronal repair after brain injury are important risk factors for ND dysfunction after surgery for CHD.
@article{gaynor_validation_2014,
title = {Validation of association of the apolipoprotein {E} ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.},
volume = {148},
url = {https://www.ncbi.nlm.nih.gov/pubmed/25282659},
doi = {10.1016/j.jtcvs.2014.07.052},
abstract = {OBJECTIVE: Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. The APOE ε2 allele has been associated with worse neurodevelopmental (ND) outcome after repair of congenital heart defects (CHD) in infancy. Replication of this finding in an independent cohort is essential to validate the observed genotype-phenotype association. METHODS: The association of APOE genotype with ND outcomes was assessed in a combined cohort of patients with single-ventricle CHD enrolled in the Single Ventricle Reconstruction and Infant Single Ventricle trials. ND outcome was assessed at 14 months using the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Development-II. Stepwise multivariable regression was performed to develop predictive models for PDI and MDI scores. RESULTS: Complete data were available for 298 of 435 patients. After adjustment for preoperative and postoperative covariates, the APOE ε2 allele was associated with a lower PDI score (P = .038). Patients with the ε2 allele had a PDI score approximately 6 points lower than those without the risk allele, explaining 1.04\% of overall PDI variance, because the ε2 allele was present in only 11\% of the patients. There was a marginal effect of the ε2 allele on MDI scores (P = .058). CONCLUSIONS: These data validate the association of the APOE ε2 allele with adverse early ND outcomes after cardiac surgery in infants, independent of patient and operative factors. Genetic variants that decrease neuroresilience and impair neuronal repair after brain injury are important risk factors for ND dysfunction after surgery for CHD.},
language = {eng},
number = {6},
journal = {J Thorac Cardiovasc Surg},
author = {Gaynor, JW and Kim, DS and Arrington, CB and Atz, AM and Bellinger, DC and Burt, AA and Ghanayem, NS and Jacobs, JP and Lee, TM and Lewis, AB and Mahle, WT and Marino, BS and Miller, SG and Newburger, JW and Pizarro, C and Ravishankar, C and Santani, AB and Wilder, NS and Jarvik, GP and Mital, S and Russell, MW},
month = dec,
year = {2014},
keywords = {Risk Factors},
pages = {2560--2566}
}
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{"_id":"gkpvDiknkWz7QXYzJ","bibbaseid":"gaynor-kim-arrington-atz-bellinger-burt-ghanayem-jacobs-etal-validationofassociationoftheapolipoproteine2allelewithneurodevelopmentaldysfunctionaftercardiacsurgeryinneonatesandinfants-2014","downloads":0,"creationDate":"2019-02-06T19:35:20.867Z","title":"Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.","author_short":["Gaynor, J.","Kim, D.","Arrington, C.","Atz, A.","Bellinger, D.","Burt, A.","Ghanayem, N.","Jacobs, J.","Lee, T.","Lewis, A.","Mahle, W.","Marino, B.","Miller, S.","Newburger, J.","Pizarro, C","Ravishankar, C","Santani, A.","Wilder, N.","Jarvik, G.","Mital, S","Russell, M."],"year":2014,"bibtype":"article","biburl":"https://api.zotero.org/users/5494130/collections/TR8UM4WJ/items?key=DEUYuiNYuDld2Xdzn5K5sy3H&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.","volume":"148","url":"https://www.ncbi.nlm.nih.gov/pubmed/25282659","doi":"10.1016/j.jtcvs.2014.07.052","abstract":"OBJECTIVE: Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. The APOE ε2 allele has been associated with worse neurodevelopmental (ND) outcome after repair of congenital heart defects (CHD) in infancy. Replication of this finding in an independent cohort is essential to validate the observed genotype-phenotype association. METHODS: The association of APOE genotype with ND outcomes was assessed in a combined cohort of patients with single-ventricle CHD enrolled in the Single Ventricle Reconstruction and Infant Single Ventricle trials. ND outcome was assessed at 14 months using the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Development-II. Stepwise multivariable regression was performed to develop predictive models for PDI and MDI scores. RESULTS: Complete data were available for 298 of 435 patients. After adjustment for preoperative and postoperative covariates, the APOE ε2 allele was associated with a lower PDI score (P = .038). Patients with the ε2 allele had a PDI score approximately 6 points lower than those without the risk allele, explaining 1.04% of overall PDI variance, because the ε2 allele was present in only 11% of the patients. There was a marginal effect of the ε2 allele on MDI scores (P = .058). CONCLUSIONS: These data validate the association of the APOE ε2 allele with adverse early ND outcomes after cardiac surgery in infants, independent of patient and operative factors. Genetic variants that decrease neuroresilience and impair neuronal repair after brain injury are important risk factors for ND dysfunction after surgery for CHD.","language":"eng","number":"6","journal":"J Thorac Cardiovasc Surg","author":[{"propositions":[],"lastnames":["Gaynor"],"firstnames":["JW"],"suffixes":[]},{"propositions":[],"lastnames":["Kim"],"firstnames":["DS"],"suffixes":[]},{"propositions":[],"lastnames":["Arrington"],"firstnames":["CB"],"suffixes":[]},{"propositions":[],"lastnames":["Atz"],"firstnames":["AM"],"suffixes":[]},{"propositions":[],"lastnames":["Bellinger"],"firstnames":["DC"],"suffixes":[]},{"propositions":[],"lastnames":["Burt"],"firstnames":["AA"],"suffixes":[]},{"propositions":[],"lastnames":["Ghanayem"],"firstnames":["NS"],"suffixes":[]},{"propositions":[],"lastnames":["Jacobs"],"firstnames":["JP"],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["TM"],"suffixes":[]},{"propositions":[],"lastnames":["Lewis"],"firstnames":["AB"],"suffixes":[]},{"propositions":[],"lastnames":["Mahle"],"firstnames":["WT"],"suffixes":[]},{"propositions":[],"lastnames":["Marino"],"firstnames":["BS"],"suffixes":[]},{"propositions":[],"lastnames":["Miller"],"firstnames":["SG"],"suffixes":[]},{"propositions":[],"lastnames":["Newburger"],"firstnames":["JW"],"suffixes":[]},{"propositions":[],"lastnames":["Pizarro"],"firstnames":["C"],"suffixes":[]},{"propositions":[],"lastnames":["Ravishankar"],"firstnames":["C"],"suffixes":[]},{"propositions":[],"lastnames":["Santani"],"firstnames":["AB"],"suffixes":[]},{"propositions":[],"lastnames":["Wilder"],"firstnames":["NS"],"suffixes":[]},{"propositions":[],"lastnames":["Jarvik"],"firstnames":["GP"],"suffixes":[]},{"propositions":[],"lastnames":["Mital"],"firstnames":["S"],"suffixes":[]},{"propositions":[],"lastnames":["Russell"],"firstnames":["MW"],"suffixes":[]}],"month":"December","year":"2014","keywords":"Risk Factors","pages":"2560–2566","bibtex":"@article{gaynor_validation_2014,\n\ttitle = {Validation of association of the apolipoprotein {E} ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.},\n\tvolume = {148},\n\turl = {https://www.ncbi.nlm.nih.gov/pubmed/25282659},\n\tdoi = {10.1016/j.jtcvs.2014.07.052},\n\tabstract = {OBJECTIVE: Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. The APOE ε2 allele has been associated with worse neurodevelopmental (ND) outcome after repair of congenital heart defects (CHD) in infancy. Replication of this finding in an independent cohort is essential to validate the observed genotype-phenotype association. METHODS: The association of APOE genotype with ND outcomes was assessed in a combined cohort of patients with single-ventricle CHD enrolled in the Single Ventricle Reconstruction and Infant Single Ventricle trials. ND outcome was assessed at 14 months using the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Development-II. Stepwise multivariable regression was performed to develop predictive models for PDI and MDI scores. RESULTS: Complete data were available for 298 of 435 patients. After adjustment for preoperative and postoperative covariates, the APOE ε2 allele was associated with a lower PDI score (P = .038). Patients with the ε2 allele had a PDI score approximately 6 points lower than those without the risk allele, explaining 1.04\\% of overall PDI variance, because the ε2 allele was present in only 11\\% of the patients. There was a marginal effect of the ε2 allele on MDI scores (P = .058). CONCLUSIONS: These data validate the association of the APOE ε2 allele with adverse early ND outcomes after cardiac surgery in infants, independent of patient and operative factors. Genetic variants that decrease neuroresilience and impair neuronal repair after brain injury are important risk factors for ND dysfunction after surgery for CHD.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {J Thorac Cardiovasc Surg},\n\tauthor = {Gaynor, JW and Kim, DS and Arrington, CB and Atz, AM and Bellinger, DC and Burt, AA and Ghanayem, NS and Jacobs, JP and Lee, TM and Lewis, AB and Mahle, WT and Marino, BS and Miller, SG and Newburger, JW and Pizarro, C and Ravishankar, C and Santani, AB and Wilder, NS and Jarvik, GP and Mital, S and Russell, MW},\n\tmonth = dec,\n\tyear = {2014},\n\tkeywords = {Risk Factors},\n\tpages = {2560--2566}\n}\n\n","author_short":["Gaynor, J.","Kim, D.","Arrington, C.","Atz, A.","Bellinger, D.","Burt, A.","Ghanayem, N.","Jacobs, J.","Lee, T.","Lewis, A.","Mahle, W.","Marino, B.","Miller, S.","Newburger, J.","Pizarro, C","Ravishankar, C","Santani, A.","Wilder, N.","Jarvik, G.","Mital, S","Russell, M."],"key":"gaynor_validation_2014","id":"gaynor_validation_2014","bibbaseid":"gaynor-kim-arrington-atz-bellinger-burt-ghanayem-jacobs-etal-validationofassociationoftheapolipoproteine2allelewithneurodevelopmentaldysfunctionaftercardiacsurgeryinneonatesandinfants-2014","role":"author","urls":{"Paper":"https://www.ncbi.nlm.nih.gov/pubmed/25282659"},"keyword":["Risk Factors"],"downloads":0,"html":""},"search_terms":["validation","association","apolipoprotein","allele","neurodevelopmental","dysfunction","cardiac","surgery","neonates","infants","gaynor","kim","arrington","atz","bellinger","burt","ghanayem","jacobs","lee","lewis","mahle","marino","miller","newburger","pizarro","ravishankar","santani","wilder","jarvik","mital","russell"],"keywords":["risk factors"],"authorIDs":[],"dataSources":["hCDpMxm2W25GkFxwp"]}