Polyfluoroalkyl phosphate esters and perfluoroalkyl carboxylic acids in target food samples and packaging-method development and screening. Gebbink, W. A., Ullah, S., Sandblom, O., & Berger, U. Environmental Science and Pollution Research, 20(11):7949–7958, 2013. doi abstract bibtex Polyfluoroalkyl phosphate mono-, di-, and tri-esters (mono-, di-, and triPAPs) are used to water- and grease-proof food packaging materials, and these chemicals are known precursors to perfluoroalkyl carboxylic acids (PFCAs). Existing analytical methods for PAPs lack sample clean-up steps in the sample preparation. In the present study, a method based on ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) was developed and optimized for the analysis of mono-, di-, and triPAPs, including a clean-up step for the raw extracts. The method was applied to food samples and their PAP-containing packaging materials. The optimized UPLC/MS/MS method enabled the separation and identification of a total of 4 monoPAPs, 16 diPAPs, and 7 triPAPs in the technical mixture Zonyl®-RP. For sample clean-up, weak anion exchange solid phase extraction columns were tested. PAPs standard solutions spiked onto the columns were separated into a fraction containing neutral compounds (triPAPs) and a fraction with ionic compounds (mono- and diPAPs) with recoveries between 72-110%. Method limits of quantification for food samples were in the sub to low picogram per gram range. For quantitative analysis of PAPs, compound-specific labeled internal standards showed to be essential as sorption and matrix effects were observed. Mono-, di-, and/or triPAPs were detected in all food packaging materials obtained from the Swedish market. Up to nine diPAPs were detected in the food samples, with the 6:2/6:2 and 6:2/8:2 diPAPs as the dominant compounds. DiPAP concentrations in the food samples ranged from 0.9 to 36 pg/g, which was comparable to individual PFCA concentrations in the same samples. Consumption of food packed in PAP-containing materials could be an indirect source of human exposure to PFCAs.
@article{gebbink_polyfluoroalkyl_2013,
title = {Polyfluoroalkyl phosphate esters and perfluoroalkyl carboxylic acids in target food samples and packaging-method development and screening},
volume = {20},
issn = {09441344},
doi = {10.1007/s11356-013-1596-y},
abstract = {Polyfluoroalkyl phosphate mono-, di-, and tri-esters (mono-, di-, and triPAPs) are used to water- and grease-proof food packaging materials, and these chemicals are known precursors to perfluoroalkyl carboxylic acids (PFCAs). Existing analytical methods for PAPs lack sample clean-up steps in the sample preparation. In the present study, a method based on ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) was developed and optimized for the analysis of mono-, di-, and triPAPs, including a clean-up step for the raw extracts. The method was applied to food samples and their PAP-containing packaging materials. The optimized UPLC/MS/MS method enabled the separation and identification of a total of 4 monoPAPs, 16 diPAPs, and 7 triPAPs in the technical mixture Zonyl®-RP. For sample clean-up, weak anion exchange solid phase extraction columns were tested. PAPs standard solutions spiked onto the columns were separated into a fraction containing neutral compounds (triPAPs) and a fraction with ionic compounds (mono- and diPAPs) with recoveries between 72-110\%. Method limits of quantification for food samples were in the sub to low picogram per gram range. For quantitative analysis of PAPs, compound-specific labeled internal standards showed to be essential as sorption and matrix effects were observed. Mono-, di-, and/or triPAPs were detected in all food packaging materials obtained from the Swedish market. Up to nine diPAPs were detected in the food samples, with the 6:2/6:2 and 6:2/8:2 diPAPs as the dominant compounds. DiPAP concentrations in the food samples ranged from 0.9 to 36 pg/g, which was comparable to individual PFCA concentrations in the same samples. Consumption of food packed in PAP-containing materials could be an indirect source of human exposure to PFCAs.},
number = {11},
journal = {Environmental Science and Pollution Research},
author = {Gebbink, Wouter A. and Ullah, Shahid and Sandblom, Oskar and Berger, Urs},
year = {2013},
pmid = {23494682},
keywords = {Food, Method development, PFAS, Packaging material, Polyfluoroalkyl phosphate esters (PAPs), UPLC/MS/MS, diPAPs},
pages = {7949--7958},
}
Downloads: 0
{"_id":"idLrJXzgMt7btogCc","bibbaseid":"gebbink-ullah-sandblom-berger-polyfluoroalkylphosphateestersandperfluoroalkylcarboxylicacidsintargetfoodsamplesandpackagingmethoddevelopmentandscreening-2013","author_short":["Gebbink, W. A.","Ullah, S.","Sandblom, O.","Berger, U."],"bibdata":{"bibtype":"article","type":"article","title":"Polyfluoroalkyl phosphate esters and perfluoroalkyl carboxylic acids in target food samples and packaging-method development and screening","volume":"20","issn":"09441344","doi":"10.1007/s11356-013-1596-y","abstract":"Polyfluoroalkyl phosphate mono-, di-, and tri-esters (mono-, di-, and triPAPs) are used to water- and grease-proof food packaging materials, and these chemicals are known precursors to perfluoroalkyl carboxylic acids (PFCAs). Existing analytical methods for PAPs lack sample clean-up steps in the sample preparation. In the present study, a method based on ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) was developed and optimized for the analysis of mono-, di-, and triPAPs, including a clean-up step for the raw extracts. The method was applied to food samples and their PAP-containing packaging materials. The optimized UPLC/MS/MS method enabled the separation and identification of a total of 4 monoPAPs, 16 diPAPs, and 7 triPAPs in the technical mixture Zonyl®-RP. For sample clean-up, weak anion exchange solid phase extraction columns were tested. PAPs standard solutions spiked onto the columns were separated into a fraction containing neutral compounds (triPAPs) and a fraction with ionic compounds (mono- and diPAPs) with recoveries between 72-110%. Method limits of quantification for food samples were in the sub to low picogram per gram range. For quantitative analysis of PAPs, compound-specific labeled internal standards showed to be essential as sorption and matrix effects were observed. Mono-, di-, and/or triPAPs were detected in all food packaging materials obtained from the Swedish market. Up to nine diPAPs were detected in the food samples, with the 6:2/6:2 and 6:2/8:2 diPAPs as the dominant compounds. DiPAP concentrations in the food samples ranged from 0.9 to 36 pg/g, which was comparable to individual PFCA concentrations in the same samples. Consumption of food packed in PAP-containing materials could be an indirect source of human exposure to PFCAs.","number":"11","journal":"Environmental Science and Pollution Research","author":[{"propositions":[],"lastnames":["Gebbink"],"firstnames":["Wouter","A."],"suffixes":[]},{"propositions":[],"lastnames":["Ullah"],"firstnames":["Shahid"],"suffixes":[]},{"propositions":[],"lastnames":["Sandblom"],"firstnames":["Oskar"],"suffixes":[]},{"propositions":[],"lastnames":["Berger"],"firstnames":["Urs"],"suffixes":[]}],"year":"2013","pmid":"23494682","keywords":"Food, Method development, PFAS, Packaging material, Polyfluoroalkyl phosphate esters (PAPs), UPLC/MS/MS, diPAPs","pages":"7949–7958","bibtex":"@article{gebbink_polyfluoroalkyl_2013,\n\ttitle = {Polyfluoroalkyl phosphate esters and perfluoroalkyl carboxylic acids in target food samples and packaging-method development and screening},\n\tvolume = {20},\n\tissn = {09441344},\n\tdoi = {10.1007/s11356-013-1596-y},\n\tabstract = {Polyfluoroalkyl phosphate mono-, di-, and tri-esters (mono-, di-, and triPAPs) are used to water- and grease-proof food packaging materials, and these chemicals are known precursors to perfluoroalkyl carboxylic acids (PFCAs). Existing analytical methods for PAPs lack sample clean-up steps in the sample preparation. In the present study, a method based on ultra performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) was developed and optimized for the analysis of mono-, di-, and triPAPs, including a clean-up step for the raw extracts. The method was applied to food samples and their PAP-containing packaging materials. The optimized UPLC/MS/MS method enabled the separation and identification of a total of 4 monoPAPs, 16 diPAPs, and 7 triPAPs in the technical mixture Zonyl®-RP. For sample clean-up, weak anion exchange solid phase extraction columns were tested. PAPs standard solutions spiked onto the columns were separated into a fraction containing neutral compounds (triPAPs) and a fraction with ionic compounds (mono- and diPAPs) with recoveries between 72-110\\%. Method limits of quantification for food samples were in the sub to low picogram per gram range. For quantitative analysis of PAPs, compound-specific labeled internal standards showed to be essential as sorption and matrix effects were observed. Mono-, di-, and/or triPAPs were detected in all food packaging materials obtained from the Swedish market. Up to nine diPAPs were detected in the food samples, with the 6:2/6:2 and 6:2/8:2 diPAPs as the dominant compounds. DiPAP concentrations in the food samples ranged from 0.9 to 36 pg/g, which was comparable to individual PFCA concentrations in the same samples. Consumption of food packed in PAP-containing materials could be an indirect source of human exposure to PFCAs.},\n\tnumber = {11},\n\tjournal = {Environmental Science and Pollution Research},\n\tauthor = {Gebbink, Wouter A. and Ullah, Shahid and Sandblom, Oskar and Berger, Urs},\n\tyear = {2013},\n\tpmid = {23494682},\n\tkeywords = {Food, Method development, PFAS, Packaging material, Polyfluoroalkyl phosphate esters (PAPs), UPLC/MS/MS, diPAPs},\n\tpages = {7949--7958},\n}\n\n\n\n","author_short":["Gebbink, W. A.","Ullah, S.","Sandblom, O.","Berger, U."],"key":"gebbink_polyfluoroalkyl_2013","id":"gebbink_polyfluoroalkyl_2013","bibbaseid":"gebbink-ullah-sandblom-berger-polyfluoroalkylphosphateestersandperfluoroalkylcarboxylicacidsintargetfoodsamplesandpackagingmethoddevelopmentandscreening-2013","role":"author","urls":{},"keyword":["Food","Method development","PFAS","Packaging material","Polyfluoroalkyl phosphate esters (PAPs)","UPLC/MS/MS","diPAPs"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"http://bibbase.org/zotero/mdedeo","dataSources":["SSfxPwd7XbkRtnZ9f"],"keywords":["food","method development","pfas","packaging material","polyfluoroalkyl phosphate esters (paps)","uplc/ms/ms","dipaps"],"search_terms":["polyfluoroalkyl","phosphate","esters","perfluoroalkyl","carboxylic","acids","target","food","samples","packaging","method","development","screening","gebbink","ullah","sandblom","berger"],"title":"Polyfluoroalkyl phosphate esters and perfluoroalkyl carboxylic acids in target food samples and packaging-method development and screening","year":2013}