@article{RN135,
   author = {Geboers, B. and Scheffer, H. J. and Graybill, P. M. and Ruarus, A. H. and Nieuwenhuizen, S. and Puijk, R. S. and van den Tol, P. M. and Davalos, R. V. and Rubinsky, B. and de Gruijl, T. D. and Miklavčič, D. and Meijerink, M. R.},
   title = {High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy},
   journal = {Radiology},
   volume = {295},
   number = {2},
   pages = {254-272},
   note = {1527-1315
Geboers, Bart
Orcid: 0000-0002-8137-9299
Scheffer, Hester J
Orcid: 0000-0001-6298-383x
Graybill, Philip M
Orcid: 0000-0002-2057-7478
Ruarus, Alette H
Orcid: 0000-0002-0823-6398
Nieuwenhuizen, Sanne
Orcid: 0000-0002-5219-6135
Puijk, Robbert S
Orcid: 0000-0003-3293-4433
van den Tol, Petrousjka M
Orcid: 0000-0002-0206-8741
Davalos, Rafael V
Orcid: 0000-0003-1503-9509
Rubinsky, Boris
Orcid: 0000-0002-2794-1543
de Gruijl, Tanja D
Miklavčič, Damijan
Orcid: 0000-0003-3506-9449
Meijerink, Martijn R
Orcid: 0000-0002-1500-7294
Journal Article
Review
United States
2020/03/26
Radiology. 2020 May;295(2):254-272. doi: 10.1148/radiol.2020192190. Epub 2020 Mar 24.},
   abstract = {This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). HVEPs increase the membrane permeability of cells, a phenomenon known as electroporation. Unlike alternative ablative therapies, electroporation does not affect the structural integrity of surrounding tissue, thereby enabling tumors in the vicinity of vital structures to be treated. IRE uses HVEPs to cause cell death by inducing membrane disruption, and it is primarily used as a radical ablative therapy in the treatment of soft-tissue tumors in the liver, kidney, prostate, and pancreas. ECT uses HVEPs to transiently increase membrane permeability, enhancing cellular cytotoxic drug uptake in tumors. IRE and ECT show immunogenic effects that could be augmented when combined with immunomodulatory drugs, a combination therapy the authors term electroimmunotherapy. Additional electroporation-based technologies that may reach clinical importance, such as gene electrotransfer, electrofusion, and electroimmunotherapy, are concisely reviewed. HVEPs represent a substantial advancement in cancer research, and continued improvement and implementation of these presented technologies will require close collaboration between engineers, interventional radiologists, medical oncologists, and immuno-oncologists.},
   keywords = {Antineoplastic Agents/administration & dosage
Cell Fusion/methods
Electric Stimulation Therapy/methods
Electrochemotherapy/methods
Electroporation/*methods
Gene Transfer Techniques
Humans
Immunotherapy/methods
Medical Oncology/*methods
Neoplasms/*therapy},
   ISSN = {0033-8419},
   DOI = {10.1148/radiol.2020192190},
   year = {2020},
   type = {Journal Article}
}

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R."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Geboers"],"firstnames":["B."],"suffixes":[]},{"propositions":[],"lastnames":["Scheffer"],"firstnames":["H.","J."],"suffixes":[]},{"propositions":[],"lastnames":["Graybill"],"firstnames":["P.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Ruarus"],"firstnames":["A.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Nieuwenhuizen"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Puijk"],"firstnames":["R.","S."],"suffixes":[]},{"propositions":["van","den"],"lastnames":["Tol"],"firstnames":["P.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]},{"propositions":[],"lastnames":["Rubinsky"],"firstnames":["B."],"suffixes":[]},{"propositions":["de"],"lastnames":["Gruijl"],"firstnames":["T.","D."],"suffixes":[]},{"propositions":[],"lastnames":["Miklavčič"],"firstnames":["D."],"suffixes":[]},{"propositions":[],"lastnames":["Meijerink"],"firstnames":["M.","R."],"suffixes":[]}],"title":"High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy","journal":"Radiology","volume":"295","number":"2","pages":"254-272","note":"1527-1315 Geboers, Bart Orcid: 0000-0002-8137-9299 Scheffer, Hester J Orcid: 0000-0001-6298-383x Graybill, Philip M Orcid: 0000-0002-2057-7478 Ruarus, Alette H Orcid: 0000-0002-0823-6398 Nieuwenhuizen, Sanne Orcid: 0000-0002-5219-6135 Puijk, Robbert S Orcid: 0000-0003-3293-4433 van den Tol, Petrousjka M Orcid: 0000-0002-0206-8741 Davalos, Rafael V Orcid: 0000-0003-1503-9509 Rubinsky, Boris Orcid: 0000-0002-2794-1543 de Gruijl, Tanja D Miklavčič, Damijan Orcid: 0000-0003-3506-9449 Meijerink, Martijn R Orcid: 0000-0002-1500-7294 Journal Article Review United States 2020/03/26 Radiology. 2020 May;295(2):254-272. doi: 10.1148/radiol.2020192190. Epub 2020 Mar 24.","abstract":"This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). HVEPs increase the membrane permeability of cells, a phenomenon known as electroporation. Unlike alternative ablative therapies, electroporation does not affect the structural integrity of surrounding tissue, thereby enabling tumors in the vicinity of vital structures to be treated. IRE uses HVEPs to cause cell death by inducing membrane disruption, and it is primarily used as a radical ablative therapy in the treatment of soft-tissue tumors in the liver, kidney, prostate, and pancreas. ECT uses HVEPs to transiently increase membrane permeability, enhancing cellular cytotoxic drug uptake in tumors. IRE and ECT show immunogenic effects that could be augmented when combined with immunomodulatory drugs, a combination therapy the authors term electroimmunotherapy. Additional electroporation-based technologies that may reach clinical importance, such as gene electrotransfer, electrofusion, and electroimmunotherapy, are concisely reviewed. HVEPs represent a substantial advancement in cancer research, and continued improvement and implementation of these presented technologies will require close collaboration between engineers, interventional radiologists, medical oncologists, and immuno-oncologists.","keywords":"Antineoplastic Agents/administration & dosage Cell Fusion/methods Electric Stimulation Therapy/methods Electrochemotherapy/methods Electroporation/*methods Gene Transfer Techniques Humans Immunotherapy/methods Medical Oncology/*methods Neoplasms/*therapy","issn":"0033-8419","doi":"10.1148/radiol.2020192190","year":"2020","bibtex":"@article{RN135,\n author = {Geboers, B. and Scheffer, H. J. and Graybill, P. M. and Ruarus, A. H. and Nieuwenhuizen, S. and Puijk, R. S. and van den Tol, P. M. and Davalos, R. V. and Rubinsky, B. and de Gruijl, T. D. and Miklavčič, D. and Meijerink, M. R.},\n title = {High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy},\n journal = {Radiology},\n volume = {295},\n number = {2},\n pages = {254-272},\n note = {1527-1315\nGeboers, Bart\nOrcid: 0000-0002-8137-9299\nScheffer, Hester J\nOrcid: 0000-0001-6298-383x\nGraybill, Philip M\nOrcid: 0000-0002-2057-7478\nRuarus, Alette H\nOrcid: 0000-0002-0823-6398\nNieuwenhuizen, Sanne\nOrcid: 0000-0002-5219-6135\nPuijk, Robbert S\nOrcid: 0000-0003-3293-4433\nvan den Tol, Petrousjka M\nOrcid: 0000-0002-0206-8741\nDavalos, Rafael V\nOrcid: 0000-0003-1503-9509\nRubinsky, Boris\nOrcid: 0000-0002-2794-1543\nde Gruijl, Tanja D\nMiklavčič, Damijan\nOrcid: 0000-0003-3506-9449\nMeijerink, Martijn R\nOrcid: 0000-0002-1500-7294\nJournal Article\nReview\nUnited States\n2020/03/26\nRadiology. 2020 May;295(2):254-272. doi: 10.1148/radiol.2020192190. Epub 2020 Mar 24.},\n abstract = {This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT). HVEPs increase the membrane permeability of cells, a phenomenon known as electroporation. Unlike alternative ablative therapies, electroporation does not affect the structural integrity of surrounding tissue, thereby enabling tumors in the vicinity of vital structures to be treated. IRE uses HVEPs to cause cell death by inducing membrane disruption, and it is primarily used as a radical ablative therapy in the treatment of soft-tissue tumors in the liver, kidney, prostate, and pancreas. ECT uses HVEPs to transiently increase membrane permeability, enhancing cellular cytotoxic drug uptake in tumors. IRE and ECT show immunogenic effects that could be augmented when combined with immunomodulatory drugs, a combination therapy the authors term electroimmunotherapy. 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