Brassinosteroids regulate organ boundary formation in the shoot apical meristem of Arabidopsis

Brassinosteroids regulate organ boundary formation in the shoot apical meristem of Arabidopsis. Gendron, J. M., Liu, J., Fan, M., Bai, M., Wenkel, S., Springer, P. S., Barton, M. K., & Wang, Z. Proceedings of the National Academy of Sciences, 109(51):21152–21157, December, 2012.

Paper doi abstract bibtex

Spatiotemporal control of the formation of organ primordia and organ boundaries from the stem cell niche in the shoot apical meristem (SAM) determines the patterning and architecture of plants, but the underlying signaling mechanisms remain poorly understood. Here we show that brassinosteroids (BRs) play a key role in organ boundary formation by repressing organ boundary identity genes. BR-hypersensitive mutants display organ-fusion phenotypes, whereas BR-insensitive mutants show enhanced organ boundaries. The BR-activated transcription factor BZR1 directly represses the CUP-SHAPED COTYLEDON (CUC) family of organ boundary identity genes. In WT plants, BZR1 accumulates at high levels in the nuclei of central meristem and organ primordia but at a low level in organ boundary cells to allow CUC gene expression. Activation of BR signaling represses CUC gene expression and causes organ fusion phenotypes. This study uncovers a role for BR in the spatiotemporal control of organ boundary formation and morphogenesis in the SAM.

@article{gendron_brassinosteroids_2012,
	title = {Brassinosteroids regulate organ boundary formation in the shoot apical meristem of {Arabidopsis}},
	volume = {109},
	url = {https://www.pnas.org/doi/full/10.1073/pnas.1210799110},
	doi = {10.1073/pnas.1210799110},
	abstract = {Spatiotemporal control of the formation of organ primordia and organ boundaries from the stem cell niche in the shoot apical meristem (SAM) determines the patterning and architecture of plants, but the underlying signaling mechanisms remain poorly understood. Here we show that brassinosteroids (BRs) play a key role in organ boundary formation by repressing organ boundary identity genes. BR-hypersensitive mutants display organ-fusion phenotypes, whereas BR-insensitive mutants show enhanced organ boundaries. The BR-activated transcription factor BZR1 directly represses the CUP-SHAPED COTYLEDON (CUC) family of organ boundary identity genes. In WT plants, BZR1 accumulates at high levels in the nuclei of central meristem and organ primordia but at a low level in organ boundary cells to allow CUC gene expression. Activation of BR signaling represses CUC gene expression and causes organ fusion phenotypes. This study uncovers a role for BR in the spatiotemporal control of organ boundary formation and morphogenesis in the SAM.},
	number = {51},
	urldate = {2022-11-30},
	journal = {Proceedings of the National Academy of Sciences},
	author = {Gendron, Joshua M. and Liu, Jiang-Shu and Fan, Min and Bai, Ming-Yi and Wenkel, Stephan and Springer, Patricia S. and Barton, M. Kathryn and Wang, Zhi-Yong},
	month = dec,
	year = {2012},
	pages = {21152--21157},
}

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