Draft Genome of the Filarial Nematode Parasite Brugia malayi

Draft Genome of the Filarial Nematode Parasite Brugia malayi. Ghedin, E., Wang, S., Spiro, D., Caler, E., Zhao, Q., Crabtree, J., Allen, J. E., Delcher, A. L., Guiliano, D. B., Miranda-Saavedra, D., Angiuoli, S. V., Creasy, T., Amedeo, P., Haas, B., El-Sayed, N. M., Wortman, J. R., Feldblyum, T., Tallon, L., Schatz, M., Shumway, M., Koo, H., Salzberg, S. L., Schobel, S., Pertea, M., Pop, M., White, O., Barton, G. J., Carlow, C. K. S., Crawford, M. J., Daub, J., Dimmic, M. W., Estes, C. F., Foster, J. M., Ganatra, M., Gregory, W. F., Johnson, N. M., Jin, J., Komuniecki, R., Korf, I., Kumar, S., Laney, S., Li, B., Li, W., Lindblom, T. H., Lustigman, S., Ma, D., Maina, C. V., Martin, D. M. A., McCarter, J. P., McReynolds, L., Mitreva, M., Nutman, T. B., Parkinson, J., Peregrin-Alvarez, J. M., Poole, C., Ren, Q., Saunders, L., Sluder, A. E., Smith, K., Stanke, M., Unnasch, T. R., Ware, J., Wei, A. D., Weil, G., Williams, D. J., Zhang, Y., Williams, S. A., Fraser-Liggett, C., Slatko, B., Blaxter, M. L., & Scott, A. L. Science, 317(5845):1756–1760, September, 2007.
doi abstract bibtex

Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the [\textasciitilde]90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict [\textasciitilde]11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during [\textasciitilde]350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.

@article{ghedin_draft_2007,
  abstract = {Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the [{\textasciitilde}]90 megabase {(Mb)} genome of the human filarial parasite Brugia malayi and predict [{\textasciitilde}]11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local synteny during [{\textasciitilde}]350 million years of evolution, they largely remain in linkage on chromosomal units. More than 100 conserved operons were identified. Analysis of the predicted proteome provides evidence for adaptations of B. malayi to niches in its human and vector hosts and insights into the molecular basis of a mutualistic relationship with its Wolbachia endosymbiont. These findings offer a foundation for rational drug design.},
  added-at = {2009-12-09T17:59:08.000+0100},
  author = {Ghedin, Elodie and Wang, Shiliang and Spiro, David and Caler, Elisabet and Zhao, Qi and Crabtree, Jonathan and Allen, Jonathan E. and Delcher, Arthur L. and Guiliano, David B. and {Miranda-Saavedra}, Diego and Angiuoli, Samuel V. and Creasy, Todd and Amedeo, Paolo and Haas, Brian and {El-Sayed}, Najib M. and Wortman, Jennifer R. and Feldblyum, Tamara and Tallon, Luke and Schatz, Michael and Shumway, Martin and Koo, Hean and Salzberg, Steven L. and Schobel, Seth and Pertea, Mihaela and Pop, Mihai and White, Owen and Barton, Geoffrey J. and Carlow, Clotilde K. S. and Crawford, Michael J. and Daub, Jennifer and Dimmic, Matthew W. and Estes, Chris F. and Foster, Jeremy M. and Ganatra, Mehul and Gregory, William F. and Johnson, Nicholas M. and Jin, Jinming and Komuniecki, Richard and Korf, Ian and Kumar, Sanjay and Laney, Sandra and Li, {Ben-Wen} and Li, Wen and Lindblom, Tim H. and Lustigman, Sara and Ma, Dong and Maina, Claude V. and Martin, David M. A. and {McCarter}, James P. and {McReynolds}, Larry and Mitreva, Makedonka and Nutman, Thomas B. and Parkinson, John and {Peregrin-Alvarez}, Jose M. and Poole, Catherine and Ren, Qinghu and Saunders, Lori and Sluder, Ann E. and Smith, Katherine and Stanke, Mario and Unnasch, Thomas R. and Ware, Jenna and Wei, Aguan D. and Weil, Gary and Williams, Deryck J. and Zhang, Yinhua and Williams, Steven A. and {Fraser-Liggett}, Claire and Slatko, Barton and Blaxter, Mark L. and Scott, Alan L.},
  biburl = {https://www.bibsonomy.org/bibtex/2f7424b20dab42e864191b33cb3f2ccc7/derele},
  description = {my big master bibtex file},
  doi = {10.1126/science.1145406},
  interhash = {606d9826d127a7c88696bb4e4cebe01f},
  intrahash = {f7424b20dab42e864191b33cb3f2ccc7},
  journal = {Science},
  keywords = {imported},
  month = {September},
  number = 5845,
  opturl = {http://www.sciencemag.org/cgi/content/abstract/317/5845/1756},
  pages = {1756--1760},
  timestamp = {2009-12-09T18:00:11.000+0100},
  title = {Draft Genome of the Filarial Nematode Parasite Brugia malayi},
  volume = 317,
  year = 2007
}

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