Clinical efficacy of second generation tyrosine kinase inhibitor and 5-azacytidine combination in chronic myelogenous leukaemia in myeloid blast crisis. Ghez, D., Micol, J., Pasquier, F., Auger, N., Saada, V., Spentchian, M., Ianotto, J., Bourhis, J., Bennaceur-Griscelli, A., Terré, C., Castaigne, S., Rigaudeau, S., Rousselot, P., & de Botton, S. European Journal of Cancer (Oxford, England: 1990), 49(17):3666–3670, November, 2013. doi abstract bibtex Even in the tyrosine kinase inhibitors era, the prognosis of patients with chronic myeloid leukaemia in myeloid blast crisis remains dismal with few patients surviving longer than 6 months. Here we report the cases of 5 patients treated with the combination of 5-azacytidine and tyrosine kinase inhibitors for myeloid blast crisis CML. All patients achieved a complete haematological response including two with a complete cytogenetic and major molecular response. Two patients underwent an allogeneic stem cell transplantation. One died from relapse 34 months from diagnosis. The second is alive and free from disease at 11 months from diagnosis. The other 3 patients are still in complete haematological response after 15, 24 and 33 months of follow-up. These results suggest that the combination has a significant activity in myeloid blast crisis and may increase survival.
@article{ghez_clinical_2013,
title = {Clinical efficacy of second generation tyrosine kinase inhibitor and 5-azacytidine combination in chronic myelogenous leukaemia in myeloid blast crisis},
volume = {49},
issn = {1879-0852},
doi = {10.1016/j.ejca.2013.07.147},
abstract = {Even in the tyrosine kinase inhibitors era, the prognosis of patients with chronic myeloid leukaemia in myeloid blast crisis remains dismal with few patients surviving longer than 6 months. Here we report the cases of 5 patients treated with the combination of 5-azacytidine and tyrosine kinase inhibitors for myeloid blast crisis CML. All patients achieved a complete haematological response including two with a complete cytogenetic and major molecular response. Two patients underwent an allogeneic stem cell transplantation. One died from relapse 34 months from diagnosis. The second is alive and free from disease at 11 months from diagnosis. The other 3 patients are still in complete haematological response after 15, 24 and 33 months of follow-up. These results suggest that the combination has a significant activity in myeloid blast crisis and may increase survival.},
language = {eng},
number = {17},
journal = {European Journal of Cancer (Oxford, England: 1990)},
author = {Ghez, David and Micol, Jean-Baptiste and Pasquier, Florence and Auger, Nathalie and Saada, Véronique and Spentchian, Marc and Ianotto, Jean-Christophe and Bourhis, Jean-Henri and Bennaceur-Griscelli, Anelyse and Terré, Christine and Castaigne, Sylvie and Rigaudeau, Sophie and Rousselot, Philippe and de Botton, Stéphane},
month = nov,
year = {2013},
pmid = {23968731},
keywords = {Aged, Humans, Female, Male, Middle Aged, Adult, Treatment Outcome, Protein Kinase Inhibitors, Antineoplastic Combined Chemotherapy Protocols, Azacitidine, Blast Crisis, Blast phase, Chronic myelogenous leukaemia, Dasatinib, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Protein-Tyrosine Kinases, Pyrimidines, Thiazoles, Tyrosine kinase inhibitors},
pages = {3666--3670}
}
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Here we report the cases of 5 patients treated with the combination of 5-azacytidine and tyrosine kinase inhibitors for myeloid blast crisis CML. All patients achieved a complete haematological response including two with a complete cytogenetic and major molecular response. Two patients underwent an allogeneic stem cell transplantation. One died from relapse 34 months from diagnosis. The second is alive and free from disease at 11 months from diagnosis. The other 3 patients are still in complete haematological response after 15, 24 and 33 months of follow-up. These results suggest that the combination has a significant activity in myeloid blast crisis and may increase survival.","language":"eng","number":"17","journal":"European Journal of Cancer (Oxford, England: 1990)","author":[{"propositions":[],"lastnames":["Ghez"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Micol"],"firstnames":["Jean-Baptiste"],"suffixes":[]},{"propositions":[],"lastnames":["Pasquier"],"firstnames":["Florence"],"suffixes":[]},{"propositions":[],"lastnames":["Auger"],"firstnames":["Nathalie"],"suffixes":[]},{"propositions":[],"lastnames":["Saada"],"firstnames":["Véronique"],"suffixes":[]},{"propositions":[],"lastnames":["Spentchian"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Ianotto"],"firstnames":["Jean-Christophe"],"suffixes":[]},{"propositions":[],"lastnames":["Bourhis"],"firstnames":["Jean-Henri"],"suffixes":[]},{"propositions":[],"lastnames":["Bennaceur-Griscelli"],"firstnames":["Anelyse"],"suffixes":[]},{"propositions":[],"lastnames":["Terré"],"firstnames":["Christine"],"suffixes":[]},{"propositions":[],"lastnames":["Castaigne"],"firstnames":["Sylvie"],"suffixes":[]},{"propositions":[],"lastnames":["Rigaudeau"],"firstnames":["Sophie"],"suffixes":[]},{"propositions":[],"lastnames":["Rousselot"],"firstnames":["Philippe"],"suffixes":[]},{"propositions":["de"],"lastnames":["Botton"],"firstnames":["Stéphane"],"suffixes":[]}],"month":"November","year":"2013","pmid":"23968731","keywords":"Aged, Humans, Female, Male, Middle Aged, Adult, Treatment Outcome, Protein Kinase Inhibitors, Antineoplastic Combined Chemotherapy Protocols, Azacitidine, Blast Crisis, Blast phase, Chronic myelogenous leukaemia, Dasatinib, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Protein-Tyrosine Kinases, Pyrimidines, Thiazoles, Tyrosine kinase inhibitors","pages":"3666–3670","bibtex":"@article{ghez_clinical_2013,\n\ttitle = {Clinical efficacy of second generation tyrosine kinase inhibitor and 5-azacytidine combination in chronic myelogenous leukaemia in myeloid blast crisis},\n\tvolume = {49},\n\tissn = {1879-0852},\n\tdoi = {10.1016/j.ejca.2013.07.147},\n\tabstract = {Even in the tyrosine kinase inhibitors era, the prognosis of patients with chronic myeloid leukaemia in myeloid blast crisis remains dismal with few patients surviving longer than 6 months. Here we report the cases of 5 patients treated with the combination of 5-azacytidine and tyrosine kinase inhibitors for myeloid blast crisis CML. All patients achieved a complete haematological response including two with a complete cytogenetic and major molecular response. Two patients underwent an allogeneic stem cell transplantation. One died from relapse 34 months from diagnosis. The second is alive and free from disease at 11 months from diagnosis. The other 3 patients are still in complete haematological response after 15, 24 and 33 months of follow-up. 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