@article{Ghosh2013,
	title = {Ellipticine binds to a human telomere sequence: an additional mode of action as a putative anticancer agent?},
	volume = {52},
	issn = {1520-4995},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23697684},
	doi = {10.1021/bi400080t},
	abstract = {Polyguanine sequences fold into G-quadruplex structures in the presence of monovalent cations. It is accepted that the telomeric DNA region consists of G-quadruplex structure. There are reports that potential G-quadruplex forming motifs are also present in the promoter region of some proto-oncogenes such as c-myc, c-kit, KRAS, etc. Small molecules with the potential to stabilize the telomeric DNA quadruplex have emerged as potential anticancer agents. We have studied the interaction of ellipticine, a putative anticancer agent from a plant source, with a human telomeric DNA sequence (H24). Spectroscopic and calorimetric studies indicate that the association of ellipticine with H24 is an entropically driven phenomenon with a 2:3 (H24:ellipticine) stoichiometry. Though ellipticine binding does not induce any major structural perturbation in H24, the association leads to formation of a complex with enhanced thermal stability. An assay with the telomerase repeat amplification protocol shows that ellipticine inhibits telomerase activity in MDAMB-231 breast cancer cell line extracts. This is the first report of the quadruplex binding ability of ellipticine. Using the results, we propose that along with DNA intercalation and/or topoisomerase II inhibition, interaction with the telomeric DNA region and the resultant inhibition of telomerase activity might be an additional mode of action for its anticancer property.},
	number = {24},
	journal = {Biochemistry},
	author = {Ghosh, Saptaparni and Kar, Anirban and Chowdhury, Shantanu and Dasgupta, Dipak},
	month = jun,
	year = {2013},
	pmid = {23697684},
	keywords = {\#nosource},
	pages = {4127--37},
}

{"_id":"qj3SvYRZktJuCSGeH","bibbaseid":"ghosh-kar-chowdhury-dasgupta-ellipticinebindstoahumantelomeresequenceanadditionalmodeofactionasaputativeanticanceragent-2013","author_short":["Ghosh, S.","Kar, A.","Chowdhury, S.","Dasgupta, D."],"bibdata":{"bibtype":"article","type":"article","title":"Ellipticine binds to a human telomere sequence: an additional mode of action as a putative anticancer agent?","volume":"52","issn":"1520-4995","url":"http://www.ncbi.nlm.nih.gov/pubmed/23697684","doi":"10.1021/bi400080t","abstract":"Polyguanine sequences fold into G-quadruplex structures in the presence of monovalent cations. It is accepted that the telomeric DNA region consists of G-quadruplex structure. There are reports that potential G-quadruplex forming motifs are also present in the promoter region of some proto-oncogenes such as c-myc, c-kit, KRAS, etc. Small molecules with the potential to stabilize the telomeric DNA quadruplex have emerged as potential anticancer agents. We have studied the interaction of ellipticine, a putative anticancer agent from a plant source, with a human telomeric DNA sequence (H24). Spectroscopic and calorimetric studies indicate that the association of ellipticine with H24 is an entropically driven phenomenon with a 2:3 (H24:ellipticine) stoichiometry. Though ellipticine binding does not induce any major structural perturbation in H24, the association leads to formation of a complex with enhanced thermal stability. An assay with the telomerase repeat amplification protocol shows that ellipticine inhibits telomerase activity in MDAMB-231 breast cancer cell line extracts. This is the first report of the quadruplex binding ability of ellipticine. Using the results, we propose that along with DNA intercalation and/or topoisomerase II inhibition, interaction with the telomeric DNA region and the resultant inhibition of telomerase activity might be an additional mode of action for its anticancer property.","number":"24","journal":"Biochemistry","author":[{"propositions":[],"lastnames":["Ghosh"],"firstnames":["Saptaparni"],"suffixes":[]},{"propositions":[],"lastnames":["Kar"],"firstnames":["Anirban"],"suffixes":[]},{"propositions":[],"lastnames":["Chowdhury"],"firstnames":["Shantanu"],"suffixes":[]},{"propositions":[],"lastnames":["Dasgupta"],"firstnames":["Dipak"],"suffixes":[]}],"month":"June","year":"2013","pmid":"23697684","keywords":"#nosource","pages":"4127–37","bibtex":"@article{Ghosh2013,\n\ttitle = {Ellipticine binds to a human telomere sequence: an additional mode of action as a putative anticancer agent?},\n\tvolume = {52},\n\tissn = {1520-4995},\n\turl = {http://www.ncbi.nlm.nih.gov/pubmed/23697684},\n\tdoi = {10.1021/bi400080t},\n\tabstract = {Polyguanine sequences fold into G-quadruplex structures in the presence of monovalent cations. It is accepted that the telomeric DNA region consists of G-quadruplex structure. There are reports that potential G-quadruplex forming motifs are also present in the promoter region of some proto-oncogenes such as c-myc, c-kit, KRAS, etc. Small molecules with the potential to stabilize the telomeric DNA quadruplex have emerged as potential anticancer agents. We have studied the interaction of ellipticine, a putative anticancer agent from a plant source, with a human telomeric DNA sequence (H24). Spectroscopic and calorimetric studies indicate that the association of ellipticine with H24 is an entropically driven phenomenon with a 2:3 (H24:ellipticine) stoichiometry. Though ellipticine binding does not induce any major structural perturbation in H24, the association leads to formation of a complex with enhanced thermal stability. An assay with the telomerase repeat amplification protocol shows that ellipticine inhibits telomerase activity in MDAMB-231 breast cancer cell line extracts. This is the first report of the quadruplex binding ability of ellipticine. Using the results, we propose that along with DNA intercalation and/or topoisomerase II inhibition, interaction with the telomeric DNA region and the resultant inhibition of telomerase activity might be an additional mode of action for its anticancer property.},\n\tnumber = {24},\n\tjournal = {Biochemistry},\n\tauthor = {Ghosh, Saptaparni and Kar, Anirban and Chowdhury, Shantanu and Dasgupta, Dipak},\n\tmonth = jun,\n\tyear = {2013},\n\tpmid = {23697684},\n\tkeywords = {\\#nosource},\n\tpages = {4127--37},\n}\n\n","author_short":["Ghosh, S.","Kar, A.","Chowdhury, S.","Dasgupta, D."],"key":"Ghosh2013","id":"Ghosh2013","bibbaseid":"ghosh-kar-chowdhury-dasgupta-ellipticinebindstoahumantelomeresequenceanadditionalmodeofactionasaputativeanticanceragent-2013","role":"author","urls":{"Paper":"http://www.ncbi.nlm.nih.gov/pubmed/23697684"},"keyword":["#nosource"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/eric.larG4","dataSources":["4i5C7S78DvJNsaHyg","5L2zM5wNE5CBYNuea"],"keywords":["#nosource"],"search_terms":["ellipticine","binds","human","telomere","sequence","additional","mode","action","putative","anticancer","agent","ghosh","kar","chowdhury","dasgupta"],"title":"Ellipticine binds to a human telomere sequence: an additional mode of action as a putative anticancer agent?","year":2013}