Virologic correlates of anti-CMV IgG levels in HIV-1-infected men. Gianella, S., Morris, S. R., Tatro, E., Vargas, M. V., Haubrich, R. H., Daar, E. S., Dube, M. P., Richman, D. D., Little, S. J., & Smith, D. M. The Journal of Infectious Diseases, 209(3):452–456, February, 2014. doi abstract bibtex In human immunodeficiency virus (HIV)-infected individuals, higher levels of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) antibody have been associated with increased immune activation, increased HIV transmission, cardiovascular complications, and neurocognitive impairment. However, the mechanism of these observations is unknown. This analysis of 228 HIV-infected men found that higher CMV IgG levels were positively associated with older age and antiretroviral treatment. Higher frequency of detectable CMV in peripheral blood mononuclear cells and recurrent seminal CMV reactivations were associated with lower plasma CMV IgG levels, suggesting that immune response to CMV rather than direct effect of viral replication is likely responsible for adverse clinical outcome observed in other studies.
@article{gianella_virologic_2014,
title = {Virologic correlates of anti-{CMV} {IgG} levels in {HIV}-1-infected men},
volume = {209},
issn = {1537-6613},
doi = {10.1093/infdis/jit434},
abstract = {In human immunodeficiency virus (HIV)-infected individuals, higher levels of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) antibody have been associated with increased immune activation, increased HIV transmission, cardiovascular complications, and neurocognitive impairment. However, the mechanism of these observations is unknown. This analysis of 228 HIV-infected men found that higher CMV IgG levels were positively associated with older age and antiretroviral treatment. Higher frequency of detectable CMV in peripheral blood mononuclear cells and recurrent seminal CMV reactivations were associated with lower plasma CMV IgG levels, suggesting that immune response to CMV rather than direct effect of viral replication is likely responsible for adverse clinical outcome observed in other studies.},
language = {eng},
number = {3},
journal = {The Journal of Infectious Diseases},
author = {Gianella, Sara and Morris, Sheldon R. and Tatro, Erick and Vargas, Milenka V. and Haubrich, Richard H. and Daar, Eric S. and Dube, Michael P. and Richman, Douglas D. and Little, Susan J. and Smith, Davey M.},
month = feb,
year = {2014},
pmid = {23964106},
pmcid = {PMC3883163},
keywords = {Adult, Antibodies, Viral, CMV IgG, CMV replication, Cytomegalovirus, Cytomegalovirus Infections, HIV Infections, HIV infection, Humans, Immunoglobulin G, Male, Middle Aged, Viral Load, immune response},
pages = {452--456},
}
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