Vaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Uganda. Gianella, S., Redd, A. D., Grabowski, M. K., Tobian, A. A. R., Serwadda, D., Newell, K., Patel, E. U., Kalibbala, S., Ssebbowa, P., Gray, R. H., Quinn, T. C., & Reynolds, S. J. The Journal of Infectious Diseases, 212(6):899–903, September, 2015. doi abstract bibtex Vaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0%) and 379 of 1080 individual visits (35.1%). ART status, higher HIV RNA viral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P \textless .01). Compared to pre-ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.
@article{gianella_vaginal_2015,
title = {Vaginal {Cytomegalovirus} {Shedding} {Before} and {After} {Initiation} of {Antiretroviral} {Therapy} in {Rakai}, {Uganda}},
volume = {212},
issn = {1537-6613},
doi = {10.1093/infdis/jiv135},
abstract = {Vaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0\%) and 379 of 1080 individual visits (35.1\%). ART status, higher HIV RNA viral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P {\textless} .01). Compared to pre-ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.},
language = {eng},
number = {6},
journal = {The Journal of Infectious Diseases},
author = {Gianella, Sara and Redd, Andrew D. and Grabowski, Mary K. and Tobian, Aaron A. R. and Serwadda, David and Newell, Kevin and Patel, Eshan U. and Kalibbala, Sarah and Ssebbowa, Paschal and Gray, Ronald H. and Quinn, Thomas C. and Reynolds, Steven J.},
month = sep,
year = {2015},
pmid = {25743428},
pmcid = {PMC4548459},
keywords = {Acyclovir, Adult, Anti-Retroviral Agents, CD4 Lymphocyte Count, Coinfection, Cytomegalovirus, Cytomegalovirus Infections, Double-Blind Method, Female, HIV Infections, Herpes Genitalis, Herpesvirus 2, Human, Humans, Longitudinal Studies, Uganda, Vagina, Virus Shedding, acyclovir, antiretroviral therapy (ART), cytomegalovirus (CMV), human immunodeficiency virus (HIV), immune reconstitution inflammatory syndrome (IRIS), reactivation},
pages = {899--903},
}
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J."],"year":2015,"bibtype":"article","biburl":"https://bibbase.org/zotero/ucsdpirc","bibdata":{"bibtype":"article","type":"article","title":"Vaginal Cytomegalovirus Shedding Before and After Initiation of Antiretroviral Therapy in Rakai, Uganda","volume":"212","issn":"1537-6613","doi":"10.1093/infdis/jiv135","abstract":"Vaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0%) and 379 of 1080 individual visits (35.1%). ART status, higher HIV RNA viral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P \\textless .01). Compared to pre-ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.","language":"eng","number":"6","journal":"The Journal of Infectious Diseases","author":[{"propositions":[],"lastnames":["Gianella"],"firstnames":["Sara"],"suffixes":[]},{"propositions":[],"lastnames":["Redd"],"firstnames":["Andrew","D."],"suffixes":[]},{"propositions":[],"lastnames":["Grabowski"],"firstnames":["Mary","K."],"suffixes":[]},{"propositions":[],"lastnames":["Tobian"],"firstnames":["Aaron","A.","R."],"suffixes":[]},{"propositions":[],"lastnames":["Serwadda"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Newell"],"firstnames":["Kevin"],"suffixes":[]},{"propositions":[],"lastnames":["Patel"],"firstnames":["Eshan","U."],"suffixes":[]},{"propositions":[],"lastnames":["Kalibbala"],"firstnames":["Sarah"],"suffixes":[]},{"propositions":[],"lastnames":["Ssebbowa"],"firstnames":["Paschal"],"suffixes":[]},{"propositions":[],"lastnames":["Gray"],"firstnames":["Ronald","H."],"suffixes":[]},{"propositions":[],"lastnames":["Quinn"],"firstnames":["Thomas","C."],"suffixes":[]},{"propositions":[],"lastnames":["Reynolds"],"firstnames":["Steven","J."],"suffixes":[]}],"month":"September","year":"2015","pmid":"25743428","pmcid":"PMC4548459","keywords":"Acyclovir, Adult, Anti-Retroviral Agents, CD4 Lymphocyte Count, Coinfection, Cytomegalovirus, Cytomegalovirus Infections, Double-Blind Method, Female, HIV Infections, Herpes Genitalis, Herpesvirus 2, Human, Humans, Longitudinal Studies, Uganda, Vagina, Virus Shedding, acyclovir, antiretroviral therapy (ART), cytomegalovirus (CMV), human immunodeficiency virus (HIV), immune reconstitution inflammatory syndrome (IRIS), reactivation","pages":"899–903","bibtex":"@article{gianella_vaginal_2015,\n\ttitle = {Vaginal {Cytomegalovirus} {Shedding} {Before} and {After} {Initiation} of {Antiretroviral} {Therapy} in {Rakai}, {Uganda}},\n\tvolume = {212},\n\tissn = {1537-6613},\n\tdoi = {10.1093/infdis/jiv135},\n\tabstract = {Vaginal shedding of cytomegalovirus (CMV) DNA was determined longitudinally among 96 women coinfected with human immunodeficiency virus (HIV), herpes simplex virus 2, and CMV starting antiretroviral therapy (ART) during a placebo-controlled trial of HSV-2 suppression with acyclovir in Rakai, Uganda. Vaginal CMV was detected in 75 of 96 women (78.0\\%) and 379 of 1080 individual visits (35.1\\%). ART status, higher HIV RNA viral load before ART initiation, and younger age were significantly associated with increased frequency of CMV shedding (P {\\textless} .01). Compared to pre-ART, CMV shedding peaked from month 2 to month 4 after ART initiation, suggesting possible immune reconstitution inflammatory syndrome. Further studies need to determine the clinical significance of asymptomatic CMV shedding.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {The Journal of Infectious Diseases},\n\tauthor = {Gianella, Sara and Redd, Andrew D. and Grabowski, Mary K. and Tobian, Aaron A. 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