Effects of severe acute respiratory syndrome coronavirus 2 infection on obstetric outcomes: Results from a prospective cohort in the Netherlands

Effects of severe acute respiratory syndrome coronavirus 2 infection on obstetric outcomes: Results from a prospective cohort in the Netherlands. Gigase, F., A., J., Boekhorst, M., G., B., M., Rommel, A., S., Dolan, S., M., Pop, V., Bergink, V., De Witte, L., D., Pop, |., V., Bergink, |., V., Lotje, |., & De Witte, D. International Journal of Gynecology & Obstetrics, 160(1):337-339, John Wiley & Sons, Ltd, 9, 2023.

Paper

Website doi abstract bibtex

Funding information Icahn School of Medicine at Mount Sinai Keywords birth weight, COVID-19, gestational age, obstetric outcomes, SARS-CoV-2 infection Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy has been associated with adverse obstetric outcomes. 1 Most studies included symptomatic or hospitalized patients or patients infected in the third trimester or lacked appropriate control groups. Three studies identified patients infected in early pregnancy based on antibody status and reported no increased risk of adverse outcomes. 2,3 These results suggest that severity and timing are important determinants of adverse outcomes of SARS-CoV-2 infection during pregnancy. We assessed whether SARS-CoV-2 infection before 28 weeks of gestation is associated with selected ob-stetric outcomes. We analyzed data from 1031 participants in a prospective pregnancy cohort in the Netherlands (Brabant study, previously described and approved by the medical ethical committee of the Máxima Medical Center Veldhoven [#NL64091.015.17]). 4 Recruitment started in 2018 prepandemic and continued through November 1, 2021. Demographic, laboratory, and obstetric characteristics were collected at 12, 20, and 28 weeks of gestation and 8 weeks postpartum and did not differ from the main cohort. Past SARS-CoV-2 infection was assessed using repeated serological testing for IgG antibodies to the SARS-CoV-2 nucle-ocapsid (N) protein and self-reported results from coronavirus disease 2019 (COVID-19) tests. Linear and logistic regression models of each obstetric outcome were adjusted using stepwise procedures for potential covariates in SPSS software version 28.0 (IBM). A total of 77 of 1031 participants (7.5%) were infected with SARS-CoV-2 before 28 weeks of gestation (41 [4%] during pregnancy , 14 [1.4%] before pregnancy, and 22 [2%] unknown timing). Participants with evidence of SARS-CoV-2 infection were younger (t[999], 1.99; P = 0.047, d = 0.24) and more often nulliparous (X 2 [1, N = 1031], 5.69; P = 0.017, V = 0.076) compared with uninfected participants. After adjustment, we found no association of SARS-CoV-2 infection before 28 weeks of gestation with selected obstet-ric outcomes (Table 1). A sensitivity analysis restricted to infections during pregnancy (n = 41) also showed no association (results not shown). We did not find an association between SARS-CoV-2 infection before 28 weeks of gestation and adverse obstetric outcomes. Our results are consistent with three studies showing a similar rate of pregnancy complications among participants infected with SARS-CoV-2 in early to mid-pregnancy compared with nonin-fected pregnant women. 2,3 A key strength of this study, inherent to the prospective design, is the unbiased sample of pregnant This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

@article{
 title = {Effects of severe acute respiratory syndrome coronavirus 2 infection on obstetric outcomes: Results from a prospective cohort in the Netherlands},
 type = {article},
 year = {2023},
 keywords = {19,2 infection,COVID,CoV,SARS,birth weight,gestational age,obstetric outcomes},
 pages = {337-339},
 volume = {160},
 websites = {https://onlinelibrary.wiley.com/doi/full/10.1002/ijgo.14405,https://onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.14405,https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14405},
 month = {9},
 publisher = {John Wiley & Sons, Ltd},
 day = {1},
 id = {e46c1b69-ed40-37aa-b4ec-598aa610fad5},
 created = {2022-12-14T15:22:45.956Z},
 accessed = {2022-09-02},
 file_attached = {true},
 profile_id = {031c901b-e377-3792-995f-e5d0201f5174},
 last_modified = {2022-12-14T15:32:43.153Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 folder_uuids = {587bd3ee-2583-429f-bd31-12ed8aa89b37},
 private_publication = {false},
 abstract = {Funding information Icahn School of Medicine at Mount Sinai Keywords birth weight, COVID-19, gestational age, obstetric outcomes, SARS-CoV-2 infection Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy has been associated with adverse obstetric outcomes. 1 Most studies included symptomatic or hospitalized patients or patients infected in the third trimester or lacked appropriate control groups. Three studies identified patients infected in early pregnancy based on antibody status and reported no increased risk of adverse outcomes. 2,3 These results suggest that severity and timing are important determinants of adverse outcomes of SARS-CoV-2 infection during pregnancy. We assessed whether SARS-CoV-2 infection before 28 weeks of gestation is associated with selected ob-stetric outcomes. We analyzed data from 1031 participants in a prospective pregnancy cohort in the Netherlands (Brabant study, previously described and approved by the medical ethical committee of the Máxima Medical Center Veldhoven [#NL64091.015.17]). 4 Recruitment started in 2018 prepandemic and continued through November 1, 2021. Demographic, laboratory, and obstetric characteristics were collected at 12, 20, and 28 weeks of gestation and 8 weeks postpartum and did not differ from the main cohort. Past SARS-CoV-2 infection was assessed using repeated serological testing for IgG antibodies to the SARS-CoV-2 nucle-ocapsid (N) protein and self-reported results from coronavirus disease 2019 (COVID-19) tests. Linear and logistic regression models of each obstetric outcome were adjusted using stepwise procedures for potential covariates in SPSS software version 28.0 (IBM). A total of 77 of 1031 participants (7.5%) were infected with SARS-CoV-2 before 28 weeks of gestation (41 [4%] during pregnancy , 14 [1.4%] before pregnancy, and 22 [2%] unknown timing). Participants with evidence of SARS-CoV-2 infection were younger (t[999], 1.99; P = 0.047, d = 0.24) and more often nulliparous (X 2 [1, N = 1031], 5.69; P = 0.017, V = 0.076) compared with uninfected participants. After adjustment, we found no association of SARS-CoV-2 infection before 28 weeks of gestation with selected obstet-ric outcomes (Table 1). A sensitivity analysis restricted to infections during pregnancy (n = 41) also showed no association (results not shown). We did not find an association between SARS-CoV-2 infection before 28 weeks of gestation and adverse obstetric outcomes. Our results are consistent with three studies showing a similar rate of pregnancy complications among participants infected with SARS-CoV-2 in early to mid-pregnancy compared with nonin-fected pregnant women. 2,3 A key strength of this study, inherent to the prospective design, is the unbiased sample of pregnant This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.},
 bibtype = {article},
 author = {Gigase, Frederieke A.J. J and Boekhorst, Myrthe G.B.M. B M and Rommel, Anna-Sophie Sophie and Dolan, Siobhan M. and Pop, Victor and Bergink, Veerle and De Witte, Lotje D. and Pop, | Victor and Bergink, | Veerle and Lotje, | and De Witte, D},
 doi = {10.1002/IJGO.14405},
 journal = {International Journal of Gynecology & Obstetrics},
 number = {1}
}

Downloads: 0

{"_id":"BLHuDtr2EdMzMKKSk","bibbaseid":"gigase-boekhorst-rommel-dolan-pop-bergink-dewitte-pop-etal-effectsofsevereacuterespiratorysyndromecoronavirus2infectiononobstetricoutcomesresultsfromaprospectivecohortinthenetherlands-2023","author_short":["Gigase, F., A., J.","Boekhorst, M., G., B., M.","Rommel, A., S.","Dolan, S., M.","Pop, V.","Bergink, V.","De Witte, L., D.","Pop, |., V.","Bergink, |., V.","Lotje, |.","De Witte, D."],"bibdata":{"title":"Effects of severe acute respiratory syndrome coronavirus 2 infection on obstetric outcomes: Results from a prospective cohort in the Netherlands","type":"article","year":"2023","keywords":"19,2 infection,COVID,CoV,SARS,birth weight,gestational age,obstetric outcomes","pages":"337-339","volume":"160","websites":"https://onlinelibrary.wiley.com/doi/full/10.1002/ijgo.14405,https://onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.14405,https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14405","month":"9","publisher":"John Wiley & Sons, Ltd","day":"1","id":"e46c1b69-ed40-37aa-b4ec-598aa610fad5","created":"2022-12-14T15:22:45.956Z","accessed":"2022-09-02","file_attached":"true","profile_id":"031c901b-e377-3792-995f-e5d0201f5174","last_modified":"2022-12-14T15:32:43.153Z","read":false,"starred":false,"authored":"true","confirmed":"true","hidden":false,"folder_uuids":"587bd3ee-2583-429f-bd31-12ed8aa89b37","private_publication":false,"abstract":"Funding information Icahn School of Medicine at Mount Sinai Keywords birth weight, COVID-19, gestational age, obstetric outcomes, SARS-CoV-2 infection Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy has been associated with adverse obstetric outcomes. 1 Most studies included symptomatic or hospitalized patients or patients infected in the third trimester or lacked appropriate control groups. Three studies identified patients infected in early pregnancy based on antibody status and reported no increased risk of adverse outcomes. 2,3 These results suggest that severity and timing are important determinants of adverse outcomes of SARS-CoV-2 infection during pregnancy. We assessed whether SARS-CoV-2 infection before 28 weeks of gestation is associated with selected ob-stetric outcomes. We analyzed data from 1031 participants in a prospective pregnancy cohort in the Netherlands (Brabant study, previously described and approved by the medical ethical committee of the Máxima Medical Center Veldhoven [#NL64091.015.17]). 4 Recruitment started in 2018 prepandemic and continued through November 1, 2021. Demographic, laboratory, and obstetric characteristics were collected at 12, 20, and 28 weeks of gestation and 8 weeks postpartum and did not differ from the main cohort. Past SARS-CoV-2 infection was assessed using repeated serological testing for IgG antibodies to the SARS-CoV-2 nucle-ocapsid (N) protein and self-reported results from coronavirus disease 2019 (COVID-19) tests. Linear and logistic regression models of each obstetric outcome were adjusted using stepwise procedures for potential covariates in SPSS software version 28.0 (IBM). A total of 77 of 1031 participants (7.5%) were infected with SARS-CoV-2 before 28 weeks of gestation (41 [4%] during pregnancy , 14 [1.4%] before pregnancy, and 22 [2%] unknown timing). Participants with evidence of SARS-CoV-2 infection were younger (t[999], 1.99; P = 0.047, d = 0.24) and more often nulliparous (X 2 [1, N = 1031], 5.69; P = 0.017, V = 0.076) compared with uninfected participants. After adjustment, we found no association of SARS-CoV-2 infection before 28 weeks of gestation with selected obstet-ric outcomes (Table 1). A sensitivity analysis restricted to infections during pregnancy (n = 41) also showed no association (results not shown). We did not find an association between SARS-CoV-2 infection before 28 weeks of gestation and adverse obstetric outcomes. Our results are consistent with three studies showing a similar rate of pregnancy complications among participants infected with SARS-CoV-2 in early to mid-pregnancy compared with nonin-fected pregnant women. 2,3 A key strength of this study, inherent to the prospective design, is the unbiased sample of pregnant This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.","bibtype":"article","author":"Gigase, Frederieke A.J. J and Boekhorst, Myrthe G.B.M. B M and Rommel, Anna-Sophie Sophie and Dolan, Siobhan M. and Pop, Victor and Bergink, Veerle and De Witte, Lotje D. and Pop, | Victor and Bergink, | Veerle and Lotje, | and De Witte, D","doi":"10.1002/IJGO.14405","journal":"International Journal of Gynecology & Obstetrics","number":"1","bibtex":"@article{\n title = {Effects of severe acute respiratory syndrome coronavirus 2 infection on obstetric outcomes: Results from a prospective cohort in the Netherlands},\n type = {article},\n year = {2023},\n keywords = {19,2 infection,COVID,CoV,SARS,birth weight,gestational age,obstetric outcomes},\n pages = {337-339},\n volume = {160},\n websites = {https://onlinelibrary.wiley.com/doi/full/10.1002/ijgo.14405,https://onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.14405,https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14405},\n month = {9},\n publisher = {John Wiley & Sons, Ltd},\n day = {1},\n id = {e46c1b69-ed40-37aa-b4ec-598aa610fad5},\n created = {2022-12-14T15:22:45.956Z},\n accessed = {2022-09-02},\n file_attached = {true},\n profile_id = {031c901b-e377-3792-995f-e5d0201f5174},\n last_modified = {2022-12-14T15:32:43.153Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n folder_uuids = {587bd3ee-2583-429f-bd31-12ed8aa89b37},\n private_publication = {false},\n abstract = {Funding information Icahn School of Medicine at Mount Sinai Keywords birth weight, COVID-19, gestational age, obstetric outcomes, SARS-CoV-2 infection Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy has been associated with adverse obstetric outcomes. 1 Most studies included symptomatic or hospitalized patients or patients infected in the third trimester or lacked appropriate control groups. Three studies identified patients infected in early pregnancy based on antibody status and reported no increased risk of adverse outcomes. 2,3 These results suggest that severity and timing are important determinants of adverse outcomes of SARS-CoV-2 infection during pregnancy. We assessed whether SARS-CoV-2 infection before 28 weeks of gestation is associated with selected ob-stetric outcomes. We analyzed data from 1031 participants in a prospective pregnancy cohort in the Netherlands (Brabant study, previously described and approved by the medical ethical committee of the Máxima Medical Center Veldhoven [#NL64091.015.17]). 4 Recruitment started in 2018 prepandemic and continued through November 1, 2021. Demographic, laboratory, and obstetric characteristics were collected at 12, 20, and 28 weeks of gestation and 8 weeks postpartum and did not differ from the main cohort. Past SARS-CoV-2 infection was assessed using repeated serological testing for IgG antibodies to the SARS-CoV-2 nucle-ocapsid (N) protein and self-reported results from coronavirus disease 2019 (COVID-19) tests. Linear and logistic regression models of each obstetric outcome were adjusted using stepwise procedures for potential covariates in SPSS software version 28.0 (IBM). A total of 77 of 1031 participants (7.5%) were infected with SARS-CoV-2 before 28 weeks of gestation (41 [4%] during pregnancy , 14 [1.4%] before pregnancy, and 22 [2%] unknown timing). Participants with evidence of SARS-CoV-2 infection were younger (t[999], 1.99; P = 0.047, d = 0.24) and more often nulliparous (X 2 [1, N = 1031], 5.69; P = 0.017, V = 0.076) compared with uninfected participants. After adjustment, we found no association of SARS-CoV-2 infection before 28 weeks of gestation with selected obstet-ric outcomes (Table 1). A sensitivity analysis restricted to infections during pregnancy (n = 41) also showed no association (results not shown). We did not find an association between SARS-CoV-2 infection before 28 weeks of gestation and adverse obstetric outcomes. Our results are consistent with three studies showing a similar rate of pregnancy complications among participants infected with SARS-CoV-2 in early to mid-pregnancy compared with nonin-fected pregnant women. 2,3 A key strength of this study, inherent to the prospective design, is the unbiased sample of pregnant This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.},\n bibtype = {article},\n author = {Gigase, Frederieke A.J. J and Boekhorst, Myrthe G.B.M. B M and Rommel, Anna-Sophie Sophie and Dolan, Siobhan M. and Pop, Victor and Bergink, Veerle and De Witte, Lotje D. and Pop, | Victor and Bergink, | Veerle and Lotje, | and De Witte, D},\n doi = {10.1002/IJGO.14405},\n journal = {International Journal of Gynecology & Obstetrics},\n number = {1}\n}","author_short":["Gigase, F., A., J.","Boekhorst, M., G., B., M.","Rommel, A., S.","Dolan, S., M.","Pop, V.","Bergink, V.","De Witte, L., D.","Pop, |., V.","Bergink, |., V.","Lotje, |.","De Witte, D."],"urls":{"Paper":"https://bibbase.org/service/mendeley/031c901b-e377-3792-995f-e5d0201f5174/file/0dc8939a-ab6f-fc27-62c5-c67a0a036913/Gigase_et_al___2022___Effects_of_severe_acute_respiratory_syndrome_coronavirus_2_infection_on_obstetric_outcomes_Results.pdf.pdf","Website":"https://onlinelibrary.wiley.com/doi/full/10.1002/ijgo.14405,https://onlinelibrary.wiley.com/doi/abs/10.1002/ijgo.14405,https://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14405"},"biburl":"https://bibbase.org/service/mendeley/031c901b-e377-3792-995f-e5d0201f5174","bibbaseid":"gigase-boekhorst-rommel-dolan-pop-bergink-dewitte-pop-etal-effectsofsevereacuterespiratorysyndromecoronavirus2infectiononobstetricoutcomesresultsfromaprospectivecohortinthenetherlands-2023","role":"author","keyword":["19","2 infection","COVID","CoV","SARS","birth weight","gestational age","obstetric outcomes"],"metadata":{"authorlinks":{}},"downloads":0},"bibtype":"article","biburl":"https://bibbase.org/service/mendeley/031c901b-e377-3792-995f-e5d0201f5174","dataSources":["2252seNhipfTmjEBQ"],"keywords":["19","2 infection","covid","cov","sars","birth weight","gestational age","obstetric outcomes"],"search_terms":["effects","severe","acute","respiratory","syndrome","coronavirus","infection","obstetric","outcomes","results","prospective","cohort","netherlands","gigase","boekhorst","rommel","dolan","pop","bergink","de witte","pop","bergink","lotje","de witte"],"title":"Effects of severe acute respiratory syndrome coronavirus 2 infection on obstetric outcomes: Results from a prospective cohort in the Netherlands","year":2023}