@article{gilson_incorporating_2017-1,
	title = {Incorporating {Biomarker} {Stratification} into {STAMPEDE}: an {Adaptive} {Multi}-arm, {Multi}-stage {Trial} {Platform}},
	volume = {29},
	issn = {09366555},
	shorttitle = {Incorporating {Biomarker} {Stratification} into {STAMPEDE}},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0936655517304387},
	doi = {10.1016/j.clon.2017.10.004},
	abstract = {The treatment and outcomes for advanced prostate cancer have experienced significant progress over recent years. Importantly, the additional benefits of ‘up front’ chemotherapy (docetaxel) and abiraterone, over and above conventional androgen deprivation, have been separately demonstrated in the multi-arm, multi-stage (MAMS) STAMPEDE protocol, which continues recruitment to other questions. Alongside this, insights into the underlying molecular biology and, inevitably, the molecular heterogeneity of prostate cancer are opening the door to new therapeutic approaches. Incorporating this understanding and testing these hypotheses within STAMPEDE brings new challenges to the MAMS approach, but has the potential to further improve the outlook for this disease. Ó 2017 The Royal College of Radiologists. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/).},
	language = {en},
	number = {12},
	urldate = {2021-04-28},
	journal = {Clinical Oncology},
	author = {Gilson, C. and Chowdhury, S. and Parmar, M.K.B. and Sydes, M.R.},
	month = dec,
	year = {2017},
	pages = {778--786},
	file = {Gilson et al. - 2017 - Incorporating Biomarker Stratification into STAMPE.pdf:/Users/neil.hawkins/Zotero/storage/Z9ZDGXKE/Gilson et al. - 2017 - Incorporating Biomarker Stratification into STAMPE.pdf:application/pdf},
}

{"_id":"mnhqCNa89p6Bgx7Ph","bibbaseid":"gilson-chowdhury-parmar-sydes-incorporatingbiomarkerstratificationintostampedeanadaptivemultiarmmultistagetrialplatform-2017","author_short":["Gilson, C.","Chowdhury, S.","Parmar, M.","Sydes, M."],"bibdata":{"bibtype":"article","type":"article","title":"Incorporating Biomarker Stratification into STAMPEDE: an Adaptive Multi-arm, Multi-stage Trial Platform","volume":"29","issn":"09366555","shorttitle":"Incorporating Biomarker Stratification into STAMPEDE","url":"https://linkinghub.elsevier.com/retrieve/pii/S0936655517304387","doi":"10.1016/j.clon.2017.10.004","abstract":"The treatment and outcomes for advanced prostate cancer have experienced significant progress over recent years. Importantly, the additional benefits of ‘up front’ chemotherapy (docetaxel) and abiraterone, over and above conventional androgen deprivation, have been separately demonstrated in the multi-arm, multi-stage (MAMS) STAMPEDE protocol, which continues recruitment to other questions. Alongside this, insights into the underlying molecular biology and, inevitably, the molecular heterogeneity of prostate cancer are opening the door to new therapeutic approaches. Incorporating this understanding and testing these hypotheses within STAMPEDE brings new challenges to the MAMS approach, but has the potential to further improve the outlook for this disease. Ó 2017 The Royal College of Radiologists. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/).","language":"en","number":"12","urldate":"2021-04-28","journal":"Clinical Oncology","author":[{"propositions":[],"lastnames":["Gilson"],"firstnames":["C."],"suffixes":[]},{"propositions":[],"lastnames":["Chowdhury"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Parmar"],"firstnames":["M.K.B."],"suffixes":[]},{"propositions":[],"lastnames":["Sydes"],"firstnames":["M.R."],"suffixes":[]}],"month":"December","year":"2017","pages":"778–786","file":"Gilson et al. - 2017 - Incorporating Biomarker Stratification into STAMPE.pdf:/Users/neil.hawkins/Zotero/storage/Z9ZDGXKE/Gilson et al. - 2017 - Incorporating Biomarker Stratification into STAMPE.pdf:application/pdf","bibtex":"@article{gilson_incorporating_2017-1,\n\ttitle = {Incorporating {Biomarker} {Stratification} into {STAMPEDE}: an {Adaptive} {Multi}-arm, {Multi}-stage {Trial} {Platform}},\n\tvolume = {29},\n\tissn = {09366555},\n\tshorttitle = {Incorporating {Biomarker} {Stratification} into {STAMPEDE}},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0936655517304387},\n\tdoi = {10.1016/j.clon.2017.10.004},\n\tabstract = {The treatment and outcomes for advanced prostate cancer have experienced significant progress over recent years. Importantly, the additional benefits of ‘up front’ chemotherapy (docetaxel) and abiraterone, over and above conventional androgen deprivation, have been separately demonstrated in the multi-arm, multi-stage (MAMS) STAMPEDE protocol, which continues recruitment to other questions. Alongside this, insights into the underlying molecular biology and, inevitably, the molecular heterogeneity of prostate cancer are opening the door to new therapeutic approaches. Incorporating this understanding and testing these hypotheses within STAMPEDE brings new challenges to the MAMS approach, but has the potential to further improve the outlook for this disease. Ó 2017 The Royal College of Radiologists. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/).},\n\tlanguage = {en},\n\tnumber = {12},\n\turldate = {2021-04-28},\n\tjournal = {Clinical Oncology},\n\tauthor = {Gilson, C. and Chowdhury, S. and Parmar, M.K.B. and Sydes, M.R.},\n\tmonth = dec,\n\tyear = {2017},\n\tpages = {778--786},\n\tfile = {Gilson et al. - 2017 - Incorporating Biomarker Stratification into STAMPE.pdf:/Users/neil.hawkins/Zotero/storage/Z9ZDGXKE/Gilson et al. - 2017 - Incorporating Biomarker Stratification into STAMPE.pdf:application/pdf},\n}\n\n","author_short":["Gilson, C.","Chowdhury, S.","Parmar, M.","Sydes, M."],"bibbaseid":"gilson-chowdhury-parmar-sydes-incorporatingbiomarkerstratificationintostampedeanadaptivemultiarmmultistagetrialplatform-2017","role":"author","urls":{"Paper":"https://linkinghub.elsevier.com/retrieve/pii/S0936655517304387"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/FfNE7kWA6pCvwcJZF/myPubs.bib","dataSources":["ZaHtWavQhcwZqKLNF","iRRNaRs6FkffgErta","v8uQmZsBpiqycmskv"],"keywords":[],"search_terms":["incorporating","biomarker","stratification","stampede","adaptive","multi","arm","multi","stage","trial","platform","gilson","chowdhury","parmar","sydes"],"title":"Incorporating Biomarker Stratification into STAMPEDE: an Adaptive Multi-arm, Multi-stage Trial Platform","year":2017}