@ARTICLE{Gingold2014-ns,
  title    = "A dual program for translation regulation in cellular
              proliferation and differentiation",
  author   = "Gingold, Hila and Tehler, Disa and Christoffersen, Nanna R and
              Nielsen, Morten M and Asmar, Fazila and Kooistra, Susanne M and
              Christophersen, Nicolaj S and Christensen, Lise Lotte and Borre,
              Michael and S\o{}rensen, Karina D and Andersen, Lars D and
              Andersen, Claus L and Hulleman, Esther and Wurdinger, Tom and
              Ralfki\ae{}r, Elisabeth and Helin, Kristian and Gr\o{}nb\ae{}k,
              Kirsten and Orntoft, Torben and Waszak, Sebastian M and Dahan,
              Orna and Pedersen, Jakob Skou and Lund, Anders H and Pilpel,
              Yitzhak",
  abstract = "A dichotomous choice for metazoan cells is between proliferation
              and differentiation. Measuring tRNA pools in various cell types,
              we found two distinct subsets, one that is induced in
              proliferating cells, and repressed otherwise, and another with
              the opposite signature. Correspondingly, we found that genes
              serving cell-autonomous functions and genes involved in
              multicellularity obey distinct codon usage. Proliferation-induced
              and differentiation-induced tRNAs often carry anticodons that
              correspond to the codons enriched among the cell-autonomous and
              the multicellularity genes, respectively. Because mRNAs of
              cell-autonomous genes are induced in proliferation and cancer in
              particular, the concomitant induction of their codon-enriched
              tRNAs suggests coordination between transcription and
              translation. Histone modifications indeed change similarly in the
              vicinity of cell-autonomous genes and their corresponding tRNAs,
              and in multicellularity genes and their tRNAs, suggesting the
              existence of transcriptional programs coordinating tRNA supply
              and demand. Hence, we describe the existence of two distinct
              translation programs that operate during proliferation and
              differentiation.",
  journal  = "Cell",
  volume   =  158,
  number   =  6,
  pages    = "1281--1292",
  month    =  "11~" # sep,
  year     =  2014,
  keywords = "
              cancer;codon;genereg;transcription;translation;trna;zotero;trends;Zotero
              Import (Aug 30);Zotero Import (Aug 30)/My Library;Zotero Import
              (Aug 30)/My Library/genereg;Trends",
  language = "eng",
  issn     = "0092-8674, 1097-4172",
  pmid     = "25215487",
  doi      = "10.1016/j.cell.2014.08.011"
}

{"_id":"xgB89p2LbFbh8bb4B","bibbaseid":"gingold-tehler-christoffersen-nielsen-asmar-kooistra-christophersen-christensen-etal-adualprogramfortranslationregulationincellularproliferationanddifferentiation-2014","downloads":0,"creationDate":"2016-11-21T08:58:52.498Z","title":"A dual program for translation regulation in cellular proliferation and differentiation","author_short":["Gingold, H.","Tehler, D.","Christoffersen, N. R","Nielsen, M. M","Asmar, F.","Kooistra, S. M","Christophersen, N. S","Christensen, L. L.","Borre, M.","S\\orensen, K. D","Andersen, L. D","Andersen, C. L","Hulleman, E.","Wurdinger, T.","Ralfki\\aer, E.","Helin, K.","Gr\\onb\\aek, K.","Orntoft, T.","Waszak, S. M","Dahan, O.","Pedersen, J. S.","Lund, A. H","Pilpel, Y."],"year":2014,"bibtype":"article","biburl":"https://sbamin.com/files/classics_in_biology.bib","bibdata":{"bibtype":"article","type":"article","title":"A dual program for translation regulation in cellular proliferation and differentiation","author":[{"propositions":[],"lastnames":["Gingold"],"firstnames":["Hila"],"suffixes":[]},{"propositions":[],"lastnames":["Tehler"],"firstnames":["Disa"],"suffixes":[]},{"propositions":[],"lastnames":["Christoffersen"],"firstnames":["Nanna","R"],"suffixes":[]},{"propositions":[],"lastnames":["Nielsen"],"firstnames":["Morten","M"],"suffixes":[]},{"propositions":[],"lastnames":["Asmar"],"firstnames":["Fazila"],"suffixes":[]},{"propositions":[],"lastnames":["Kooistra"],"firstnames":["Susanne","M"],"suffixes":[]},{"propositions":[],"lastnames":["Christophersen"],"firstnames":["Nicolaj","S"],"suffixes":[]},{"propositions":[],"lastnames":["Christensen"],"firstnames":["Lise","Lotte"],"suffixes":[]},{"propositions":[],"lastnames":["Borre"],"firstnames":["Michael"],"suffixes":[]},{"propositions":[],"lastnames":["S\\orensen"],"firstnames":["Karina","D"],"suffixes":[]},{"propositions":[],"lastnames":["Andersen"],"firstnames":["Lars","D"],"suffixes":[]},{"propositions":[],"lastnames":["Andersen"],"firstnames":["Claus","L"],"suffixes":[]},{"propositions":[],"lastnames":["Hulleman"],"firstnames":["Esther"],"suffixes":[]},{"propositions":[],"lastnames":["Wurdinger"],"firstnames":["Tom"],"suffixes":[]},{"propositions":[],"lastnames":["Ralfki\\aer"],"firstnames":["Elisabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Helin"],"firstnames":["Kristian"],"suffixes":[]},{"propositions":[],"lastnames":["Gr\\onb\\aek"],"firstnames":["Kirsten"],"suffixes":[]},{"propositions":[],"lastnames":["Orntoft"],"firstnames":["Torben"],"suffixes":[]},{"propositions":[],"lastnames":["Waszak"],"firstnames":["Sebastian","M"],"suffixes":[]},{"propositions":[],"lastnames":["Dahan"],"firstnames":["Orna"],"suffixes":[]},{"propositions":[],"lastnames":["Pedersen"],"firstnames":["Jakob","Skou"],"suffixes":[]},{"propositions":[],"lastnames":["Lund"],"firstnames":["Anders","H"],"suffixes":[]},{"propositions":[],"lastnames":["Pilpel"],"firstnames":["Yitzhak"],"suffixes":[]}],"abstract":"A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.","journal":"Cell","volume":"158","number":"6","pages":"1281--1292","month":"11~September","year":"2014","keywords":"cancer;codon;genereg;transcription;translation;trna;zotero;trends;Zotero Import (Aug 30);Zotero Import (Aug 30)/My Library;Zotero Import (Aug 30)/My Library/genereg;Trends","language":"eng","issn":"0092-8674, 1097-4172","pmid":"25215487","doi":"10.1016/j.cell.2014.08.011","bibtex":"@ARTICLE{Gingold2014-ns,\n title = \"A dual program for translation regulation in cellular\n proliferation and differentiation\",\n author = \"Gingold, Hila and Tehler, Disa and Christoffersen, Nanna R and\n Nielsen, Morten M and Asmar, Fazila and Kooistra, Susanne M and\n Christophersen, Nicolaj S and Christensen, Lise Lotte and Borre,\n Michael and S\\o{}rensen, Karina D and Andersen, Lars D and\n Andersen, Claus L and Hulleman, Esther and Wurdinger, Tom and\n Ralfki\\ae{}r, Elisabeth and Helin, Kristian and Gr\\o{}nb\\ae{}k,\n Kirsten and Orntoft, Torben and Waszak, Sebastian M and Dahan,\n Orna and Pedersen, Jakob Skou and Lund, Anders H and Pilpel,\n Yitzhak\",\n abstract = \"A dichotomous choice for metazoan cells is between proliferation\n and differentiation. Measuring tRNA pools in various cell types,\n we found two distinct subsets, one that is induced in\n proliferating cells, and repressed otherwise, and another with\n the opposite signature. Correspondingly, we found that genes\n serving cell-autonomous functions and genes involved in\n multicellularity obey distinct codon usage. Proliferation-induced\n and differentiation-induced tRNAs often carry anticodons that\n correspond to the codons enriched among the cell-autonomous and\n the multicellularity genes, respectively. Because mRNAs of\n cell-autonomous genes are induced in proliferation and cancer in\n particular, the concomitant induction of their codon-enriched\n tRNAs suggests coordination between transcription and\n translation. Histone modifications indeed change similarly in the\n vicinity of cell-autonomous genes and their corresponding tRNAs,\n and in multicellularity genes and their tRNAs, suggesting the\n existence of transcriptional programs coordinating tRNA supply\n and demand. Hence, we describe the existence of two distinct\n translation programs that operate during proliferation and\n differentiation.\",\n journal = \"Cell\",\n volume = 158,\n number = 6,\n pages = \"1281--1292\",\n month = \"11~\" # sep,\n year = 2014,\n keywords = \"\n cancer;codon;genereg;transcription;translation;trna;zotero;trends;Zotero\n Import (Aug 30);Zotero Import (Aug 30)/My Library;Zotero Import\n (Aug 30)/My Library/genereg;Trends\",\n language = \"eng\",\n issn = \"0092-8674, 1097-4172\",\n pmid = \"25215487\",\n doi = \"10.1016/j.cell.2014.08.011\"\n}\n\n","author_short":["Gingold, H.","Tehler, D.","Christoffersen, N. R","Nielsen, M. M","Asmar, F.","Kooistra, S. M","Christophersen, N. S","Christensen, L. L.","Borre, M.","S\\orensen, K. D","Andersen, L. D","Andersen, C. L","Hulleman, E.","Wurdinger, T.","Ralfki\\aer, E.","Helin, K.","Gr\\onb\\aek, K.","Orntoft, T.","Waszak, S. M","Dahan, O.","Pedersen, J. S.","Lund, A. 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