COMPARISON OF HUMORAL IMMUNE-RESPONSES TO TRIVALENT INFLUENZA SPLIT VACCINE IN YOUNG, MIDDLE-AGED AND ELDERLY PEOPLE. Glathe, H., Bigl, S., & Grosche, A. Vaccine, 11(7):702–705, May, 1993. Paper doi abstract bibtex A total of 296 volunteers in five different groups were immunized with one dose of the commercial 1991-1992 trivalent split influenza vaccine formulation A/Singapore/6/86 (H1N1), A/Beijing/353/89 (H3N2) and B/Yamagata/16/88. The groups differed in age (young adults, middle-aged and elderly) and history of previous vaccination. Antibodies were determined in pre- and postvaccination sera by haemagglutination inhibition assay and the results were evaluated as geometric mean titre, mean fold antibody increase, protection and response rates. No significant age-related differences among the protection rates were found. The proportion of vaccinees with antibodies greater-than-or-equal-to 40 ranged between 70 and 95%. Compared with the H3N2 and B components the antibody response to the H1N1-component was low. Residents of a nursing home fully vaccinated the previous year developed 7.6-8.4-fold antibody increases and showed 96-100% protection rates.
@article{glathe_comparison_1993,
title = {{COMPARISON} {OF} {HUMORAL} {IMMUNE}-{RESPONSES} {TO} {TRIVALENT} {INFLUENZA} {SPLIT} {VACCINE} {IN} {YOUNG}, {MIDDLE}-{AGED} {AND} {ELDERLY} {PEOPLE}},
volume = {11},
issn = {0264-410X},
url = {://WOS:A1993LD24900002},
doi = {10.1016/0264-410x(93)90252-s},
abstract = {A total of 296 volunteers in five different groups were immunized with one dose of the commercial 1991-1992 trivalent split influenza vaccine formulation A/Singapore/6/86 (H1N1), A/Beijing/353/89 (H3N2) and B/Yamagata/16/88. The groups differed in age (young adults, middle-aged and elderly) and history of previous vaccination. Antibodies were determined in pre- and postvaccination sera by haemagglutination inhibition assay and the results were evaluated as geometric mean titre, mean fold antibody increase, protection and response rates. No significant age-related differences among the protection rates were found. The proportion of vaccinees with antibodies greater-than-or-equal-to 40 ranged between 70 and 95\%. Compared with the H3N2 and B components the antibody response to the H1N1-component was low. Residents of a nursing home fully vaccinated the previous year developed 7.6-8.4-fold antibody increases and showed 96-100\% protection rates.},
language = {English},
number = {7},
journal = {Vaccine},
author = {Glathe, H. and Bigl, S. and Grosche, A.},
month = may,
year = {1993},
keywords = {Immunology, Research \& Experimental Medicine, age, antibody, efficacy, enhancement, epidemic influenza, hemagglutinin, hospitalizations, humoral antibody, immunogenicity, influenza vaccine, nucleoprotein, subunit, virus infection, volunteers},
pages = {702--705},
}
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Antibodies were determined in pre- and postvaccination sera by haemagglutination inhibition assay and the results were evaluated as geometric mean titre, mean fold antibody increase, protection and response rates. No significant age-related differences among the protection rates were found. The proportion of vaccinees with antibodies greater-than-or-equal-to 40 ranged between 70 and 95%. Compared with the H3N2 and B components the antibody response to the H1N1-component was low. Residents of a nursing home fully vaccinated the previous year developed 7.6-8.4-fold antibody increases and showed 96-100% protection rates.","language":"English","number":"7","journal":"Vaccine","author":[{"propositions":[],"lastnames":["Glathe"],"firstnames":["H."],"suffixes":[]},{"propositions":[],"lastnames":["Bigl"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Grosche"],"firstnames":["A."],"suffixes":[]}],"month":"May","year":"1993","keywords":"Immunology, Research & Experimental Medicine, age, antibody, efficacy, enhancement, epidemic influenza, hemagglutinin, hospitalizations, humoral antibody, immunogenicity, influenza vaccine, nucleoprotein, subunit, virus infection, volunteers","pages":"702–705","bibtex":"@article{glathe_comparison_1993,\n\ttitle = {{COMPARISON} {OF} {HUMORAL} {IMMUNE}-{RESPONSES} {TO} {TRIVALENT} {INFLUENZA} {SPLIT} {VACCINE} {IN} {YOUNG}, {MIDDLE}-{AGED} {AND} {ELDERLY} {PEOPLE}},\n\tvolume = {11},\n\tissn = {0264-410X},\n\turl = {://WOS:A1993LD24900002},\n\tdoi = {10.1016/0264-410x(93)90252-s},\n\tabstract = {A total of 296 volunteers in five different groups were immunized with one dose of the commercial 1991-1992 trivalent split influenza vaccine formulation A/Singapore/6/86 (H1N1), A/Beijing/353/89 (H3N2) and B/Yamagata/16/88. 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Residents of a nursing home fully vaccinated the previous year developed 7.6-8.4-fold antibody increases and showed 96-100\\% protection rates.},\n\tlanguage = {English},\n\tnumber = {7},\n\tjournal = {Vaccine},\n\tauthor = {Glathe, H. and Bigl, S. and Grosche, A.},\n\tmonth = may,\n\tyear = {1993},\n\tkeywords = {Immunology, Research \\& Experimental Medicine, age, antibody, efficacy, enhancement, epidemic influenza, hemagglutinin, hospitalizations, humoral antibody, immunogenicity, influenza vaccine, nucleoprotein, subunit, virus infection, volunteers},\n\tpages = {702--705},\n}\n\n","author_short":["Glathe, H.","Bigl, S.","Grosche, A."],"key":"glathe_comparison_1993","id":"glathe_comparison_1993","bibbaseid":"glathe-bigl-grosche-comparisonofhumoralimmuneresponsestotrivalentinfluenzasplitvaccineinyoungmiddleagedandelderlypeople-1993","role":"author","urls":{"Paper":"https://bibbase.org/zotero/://WOS:A1993LD24900002"},"keyword":["Immunology","Research & Experimental Medicine","age","antibody","efficacy","enhancement","epidemic influenza","hemagglutinin","hospitalizations","humoral antibody","immunogenicity","influenza vaccine","nucleoprotein","subunit","virus infection","volunteers"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero/vincentwntu","creationDate":"2020-01-26T03:06:33.975Z","downloads":0,"keywords":["immunology","research & experimental medicine","age","antibody","efficacy","enhancement","epidemic influenza","hemagglutinin","hospitalizations","humoral antibody","immunogenicity","influenza vaccine","nucleoprotein","subunit","virus infection","volunteers"],"search_terms":["comparison","humoral","immune","responses","trivalent","influenza","split","vaccine","young","middle","aged","elderly","people","glathe","bigl","grosche"],"title":"COMPARISON OF HUMORAL IMMUNE-RESPONSES TO TRIVALENT INFLUENZA SPLIT VACCINE IN YOUNG, MIDDLE-AGED AND ELDERLY PEOPLE","year":1993,"dataSources":["icTw8KRRMMANXJHRd"]}