Effect of Bupropion-SR on Orgasmic Dysfunction in Nondepressed Subjects: A Pilot Study. G. Modell, C. R. K. & Jack, R. S. M. Journal of Sex & Marital Therapy, 26(3):231–240, July, 2000. Publisher: Routledge _eprint: https://doi.org/10.1080/00926230050084623![Effect of Bupropion-SR on Orgasmic Dysfunction in Nondepressed Subjects: A Pilot Study [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex The objective of this study was to determine whether the aminoketone antidepressant bupropion has beneficial effects in orgasmic dysfunction. Design: Single-blind, sequential treatment order of three weeks each: placebo, bupropion-SR 150 mg/day, bupropion-SR 300 mg/ day Subjects: Nondepressed women ( n = 20) and men ( n = 10) having nonphysiologic orgasmic delay or inhibition Main Outcome Measures: Reported difficulty or delay in achieving orgasm, satisfaction with orgasm and erectile function, and subjective impressions of drug effect Results: In the women, there were significant improvements relative to baseline ( p \textless .01) on both doses of bupropion-SR in all measured aspects of sexual function, and significant improvements relative to placebo ( p \textless .05) in overall sexual satisfaction on both doses and satisfaction with intensity of orgasm on 150 mg/day (300 mg/day, p = .10). In the men, significant improvements over baseline ( p \textless .01) were observed with both doses in overall sexual satisfaction, ability to achieve an erection, and delay in reaching orgasm/ejaculation; significant improvements relative to placebo ( p \textless .05) were observed in overall sexual satisfaction on both doses, ability to achieve erection on 150 mg/ day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic function during bupropion administration. relative to placebo ( p \textless .05) were observed in overall sexual satisfaction on both doses, ability to achieve erection on 150 mg/ day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic function during bupropion administration. Conclusions: Bupropion-SR may be a useful agent for treating orgasmic delay and inhibition, and possibly disorders of sexual arousal. The results argue against bupropion’s apparent prosexual effect in depressed patients being simply a result of its antidepressant activity.
@article{g_modell_effect_2000,
title = {Effect of {Bupropion}-{SR} on {Orgasmic} {Dysfunction} in {Nondepressed} {Subjects}: {A} {Pilot} {Study}},
volume = {26},
issn = {0092-623X},
shorttitle = {Effect of {Bupropion}-{SR} on {Orgasmic} {Dysfunction} in {Nondepressed} {Subjects}},
url = {https://doi.org/10.1080/00926230050084623},
doi = {10.1080/00926230050084623},
abstract = {The objective of this study was to determine whether the aminoketone antidepressant bupropion has beneficial effects in orgasmic dysfunction. Design: Single-blind, sequential treatment order of three weeks each: placebo, bupropion-SR 150 mg/day, bupropion-SR 300 mg/ day Subjects: Nondepressed women ( n = 20) and men ( n = 10) having nonphysiologic orgasmic delay or inhibition Main Outcome Measures: Reported difficulty or delay in achieving orgasm, satisfaction with orgasm and erectile function, and subjective impressions of drug effect Results: In the women, there were significant improvements relative to baseline ( p {\textless} .01) on both doses of bupropion-SR in all measured aspects of sexual function, and significant improvements relative to placebo ( p {\textless} .05) in overall sexual satisfaction on both doses and satisfaction with intensity of orgasm on 150 mg/day (300 mg/day, p = .10). In the men, significant improvements over baseline ( p {\textless} .01) were observed with both doses in overall sexual satisfaction, ability to achieve an erection, and delay in reaching orgasm/ejaculation; significant improvements relative to placebo ( p {\textless} .05) were observed in overall sexual satisfaction on both doses, ability to achieve erection on 150 mg/ day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic function during bupropion administration. relative to placebo ( p {\textless} .05) were observed in overall sexual satisfaction on both doses, ability to achieve erection on 150 mg/ day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic function during bupropion administration. Conclusions: Bupropion-SR may be a useful agent for treating orgasmic delay and inhibition, and possibly disorders of sexual arousal. The results argue against bupropion’s apparent prosexual effect in depressed patients being simply a result of its antidepressant activity.},
number = {3},
urldate = {2021-12-28},
journal = {Journal of Sex \& Marital Therapy},
author = {G. Modell, Charles R. Katholi, Jack, Roberta S. May},
month = jul,
year = {2000},
pmid = {10929571},
note = {Publisher: Routledge
\_eprint: https://doi.org/10.1080/00926230050084623},
pages = {231--240},
}
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Design: Single-blind, sequential treatment order of three weeks each: placebo, bupropion-SR 150 mg/day, bupropion-SR 300 mg/ day Subjects: Nondepressed women ( n = 20) and men ( n = 10) having nonphysiologic orgasmic delay or inhibition Main Outcome Measures: Reported difficulty or delay in achieving orgasm, satisfaction with orgasm and erectile function, and subjective impressions of drug effect Results: In the women, there were significant improvements relative to baseline ( p \\textless .01) on both doses of bupropion-SR in all measured aspects of sexual function, and significant improvements relative to placebo ( p \\textless .05) in overall sexual satisfaction on both doses and satisfaction with intensity of orgasm on 150 mg/day (300 mg/day, p = .10). 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The results argue against bupropion’s apparent prosexual effect in depressed patients being simply a result of its antidepressant activity.","number":"3","urldate":"2021-12-28","journal":"Journal of Sex & Marital Therapy","author":[{"propositions":[],"lastnames":["G.","Modell"],"firstnames":["Charles","R.","Katholi"],"suffixes":[]},{"propositions":[],"lastnames":["Jack"],"firstnames":["Roberta","S.","May"],"suffixes":[]}],"month":"July","year":"2000","pmid":"10929571","note":"Publisher: Routledge _eprint: https://doi.org/10.1080/00926230050084623","pages":"231–240","bibtex":"@article{g_modell_effect_2000,\n\ttitle = {Effect of {Bupropion}-{SR} on {Orgasmic} {Dysfunction} in {Nondepressed} {Subjects}: {A} {Pilot} {Study}},\n\tvolume = {26},\n\tissn = {0092-623X},\n\tshorttitle = {Effect of {Bupropion}-{SR} on {Orgasmic} {Dysfunction} in {Nondepressed} {Subjects}},\n\turl = {https://doi.org/10.1080/00926230050084623},\n\tdoi = {10.1080/00926230050084623},\n\tabstract = {The objective of this study was to determine whether the aminoketone antidepressant bupropion has beneficial effects in orgasmic dysfunction. 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