To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT. Günther, G., Abu- Hussain, N., Keller, P. M, Guler, R., Mukasa, S. L, Wolmarans, K., & Thienemann, F. Respiratory Medicine Case Reports, 46:101932, Elsevier, jan, 2023. doi abstract bibtex Post-tuberculosis (TB) radiological changes and symptoms can mimic TB. PCR-based diagnostic tests can show positive results, suggesting the presence of Mycobacterium tuberculosis DNA in the absence of viable bacteria. We present a case with two episodes of previous TB. Despite workup including trace to low positive PCR results, after performing sputum analysis, bronchoalveolar lavage analysis, cyto-brush and 18F-FDG PET/CT guided transthoracic biopsy, no culturable mycobacteria were detected. 18F-FDG PET/CT showed a high metabolic activity of the biopsied lesions. More accurate strategies and tools in patients with previous TB and positive PCR results are required to make appropriate treatment decisions.
@article{Gunther2023,
abstract = {Post-tuberculosis (TB) radiological changes and symptoms can mimic TB. PCR-based diagnostic tests can show positive results, suggesting the presence of Mycobacterium tuberculosis DNA in the absence of viable bacteria. We present a case with two episodes of previous TB. Despite workup including trace to low positive PCR results, after performing sputum analysis, bronchoalveolar lavage analysis, cyto-brush and 18F-FDG PET/CT guided transthoracic biopsy, no culturable mycobacteria were detected. 18F-FDG PET/CT showed a high metabolic activity of the biopsied lesions. More accurate strategies and tools in patients with previous TB and positive PCR results are required to make appropriate treatment decisions.},
author = {G{\"{u}}nther, Gunar and {Abu- Hussain}, Nebal and Keller, Peter M and Guler, Reto and Mukasa, Sandra L and Wolmarans, Karen and Thienemann, Friedrich},
doi = {10.1016/J.RMCR.2023.101932},
file = {:C$\backslash$:/Users/01462563/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/G{\"{u}}nther et al. - 2023 - To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis.pdf:pdf},
issn = {2213-0071},
journal = {Respiratory Medicine Case Reports},
keywords = {18F-FDG PET/CT,False-positive,OA,OA{\_}PMC,Tuberculosis,fund{\_}not{\_}ack,original,recurrent},
mendeley-tags = {OA,OA{\_}PMC,fund{\_}not{\_}ack,original},
month = {jan},
pages = {101932},
pmid = {38025249},
publisher = {Elsevier},
title = {{To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT}},
volume = {46},
year = {2023}
}
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