@article{godsil_hippocampal-prefrontal_2013,
	title = {The hippocampal-prefrontal pathway: the weak link in psychiatric disorders?},
	volume = {23},
	issn = {0924-977X},
	url = {http://dx.doi.org/10.1016/j.euroneuro.2012.10.018},
	doi = {10.1016/j.euroneuro.2012.10.018},
	abstract = {While the hippocampal formation and the prefrontal cortex each have a
well-established role in cognitive and mnemonic processes, the extent and
manner in which these structures interact to achieve these functions has
not been fully delineated. Recent research in rodents compellingly
supports the idea that the projection of neurons extending from the CA1
region of the hippocampus and from the subiculum to the prefrontal cortex,
referred to here as the H-PFC pathway, is critically involved in aspects
of cognition related to executive function and to emotional regulation.
Concurrently, it is becoming evident that persons suffering from
schizophrenia, depression, and post-traumatic stress disorder display
structural anomalies and aberrant functional coupling within the
hippocampal-prefrontal circuit. Considering that these disorders involve
varying degrees of cognitive impairment and emotional dysregulation,
dysfunction in the H-PFC pathway might therefore be the common element of
their pathophysiology. This overlap might also be intertwined with the
pathway's evident susceptibility to stress and with its relationship to
the amygdala. In consequence, the H-PFC pathway is a potentially crucial
element of the pathophysiology of several psychiatric diseases, and it
offers a specific target for therapeutic intervention, which is consistent
with the recent emphasis on reframing psychiatric diseases in terms of
brain circuits.},
	number = {10},
	journal = {Eur. Neuropsychopharmacol.},
	author = {Godsil, Bill P and Kiss, Janos P and Spedding, Michael and Jay, Thérèse M},
	month = oct,
	year = {2013},
	note = {00000},
	keywords = {Depression, Hippocampus, Pathophysiology, Post-traumatic stress disorder, Prefrontal cortex, Schizophrenia, Sep 20 import, duplicate},
	pages = {1165--1181}
}

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Recent research in rodents compellingly supports the idea that the projection of neurons extending from the CA1 region of the hippocampus and from the subiculum to the prefrontal cortex, referred to here as the H-PFC pathway, is critically involved in aspects of cognition related to executive function and to emotional regulation. Concurrently, it is becoming evident that persons suffering from schizophrenia, depression, and post-traumatic stress disorder display structural anomalies and aberrant functional coupling within the hippocampal-prefrontal circuit. Considering that these disorders involve varying degrees of cognitive impairment and emotional dysregulation, dysfunction in the H-PFC pathway might therefore be the common element of their pathophysiology. This overlap might also be intertwined with the pathway's evident susceptibility to stress and with its relationship to the amygdala. In consequence, the H-PFC pathway is a potentially crucial element of the pathophysiology of several psychiatric diseases, and it offers a specific target for therapeutic intervention, which is consistent with the recent emphasis on reframing psychiatric diseases in terms of brain circuits.","number":"10","journal":"Eur. Neuropsychopharmacol.","author":[{"propositions":[],"lastnames":["Godsil"],"firstnames":["Bill","P"],"suffixes":[]},{"propositions":[],"lastnames":["Kiss"],"firstnames":["Janos","P"],"suffixes":[]},{"propositions":[],"lastnames":["Spedding"],"firstnames":["Michael"],"suffixes":[]},{"propositions":[],"lastnames":["Jay"],"firstnames":["Thérèse","M"],"suffixes":[]}],"month":"October","year":"2013","note":"00000","keywords":"Depression, Hippocampus, Pathophysiology, Post-traumatic stress disorder, Prefrontal cortex, Schizophrenia, Sep 20 import, duplicate","pages":"1165--1181","bibtex":"@article{godsil_hippocampal-prefrontal_2013,\n\ttitle = {The hippocampal-prefrontal pathway: the weak link in psychiatric disorders?},\n\tvolume = {23},\n\tissn = {0924-977X},\n\turl = {http://dx.doi.org/10.1016/j.euroneuro.2012.10.018},\n\tdoi = {10.1016/j.euroneuro.2012.10.018},\n\tabstract = {While the hippocampal formation and the prefrontal cortex each have a\nwell-established role in cognitive and mnemonic processes, the extent and\nmanner in which these structures interact to achieve these functions has\nnot been fully delineated. Recent research in rodents compellingly\nsupports the idea that the projection of neurons extending from the CA1\nregion of the hippocampus and from the subiculum to the prefrontal cortex,\nreferred to here as the H-PFC pathway, is critically involved in aspects\nof cognition related to executive function and to emotional regulation.\nConcurrently, it is becoming evident that persons suffering from\nschizophrenia, depression, and post-traumatic stress disorder display\nstructural anomalies and aberrant functional coupling within the\nhippocampal-prefrontal circuit. Considering that these disorders involve\nvarying degrees of cognitive impairment and emotional dysregulation,\ndysfunction in the H-PFC pathway might therefore be the common element of\ntheir pathophysiology. This overlap might also be intertwined with the\npathway's evident susceptibility to stress and with its relationship to\nthe amygdala. In consequence, the H-PFC pathway is a potentially crucial\nelement of the pathophysiology of several psychiatric diseases, and it\noffers a specific target for therapeutic intervention, which is consistent\nwith the recent emphasis on reframing psychiatric diseases in terms of\nbrain circuits.},\n\tnumber = {10},\n\tjournal = {Eur. Neuropsychopharmacol.},\n\tauthor = {Godsil, Bill P and Kiss, Janos P and Spedding, Michael and Jay, Thérèse M},\n\tmonth = oct,\n\tyear = {2013},\n\tnote = {00000},\n\tkeywords = {Depression, Hippocampus, Pathophysiology, Post-traumatic stress disorder, Prefrontal cortex, Schizophrenia, Sep 20 import, duplicate},\n\tpages = {1165--1181}\n}\n\n","author_short":["Godsil, B. P","Kiss, J. P","Spedding, M.","Jay, T. 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