Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves: dose escalation study and comparison with radiofrequency ablation in a porcine model. Gofeld, M., Tiennot, T., Miller, E., Rebhun, N., Mobley, S., Leblang, S., Aginsky, R., Hananel, A., & Aubry, J. Regional Anesthesia & Pain Medicine, March, 2024. 1 citations (Crossref) [2024-04-25]![Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves: dose escalation study and comparison with radiofrequency ablation in a porcine model [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Radiofrequency ablation (RFA) is a common method for alleviating chronic back pain by targeting and ablating of facet joint sensory nerves. High-intensity focused ultrasound (HIFU) is an emerging, non-invasive, image-guided technology capable of providing thermal tissue ablation. While HIFU shows promise as a potentially superior option for ablating sensory nerves, its efficacy needs validation and comparison with existing methods. Methods Nine adult pigs underwent fluoroscopy- guided HIFU ablation of eight lumbar medial branch nerves, with varying acoustic energy levels: 1000 (N=3), 1500 (N=3), or 2000 (N=3) joules (J). An additional three animals underwent standard RFA (two 90 s long lesions at 80°C) of the same eight nerves. Following 2 days of neurobehavioral observation, all 12 animals were sacrificed. The targeted tissue was excised and subjected to macropathology and micropathology, with a primary focus on the medial branch nerves. Results The percentage of ablated nerves with HIFU was 71%, 86%, and 96% for 1000 J, 1500 J, and 2000 J, respectively. In contrast, RFA achieved a 50% ablation rate. No significant adverse events occurred during the procedure or follow-up period. Conclusions These findings suggest that HIFU may be more effective than RFA in inducing thermal necrosis of the nerve.
@article{gofeld_fluoroscopy-guided_2024,
title = {Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves: dose escalation study and comparison with radiofrequency ablation in a porcine model},
issn = {1098-7339, 1532-8651},
shorttitle = {Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves},
url = {https://rapm.bmj.com/lookup/doi/10.1136/rapm-2024-105417},
doi = {10.1136/rapm-2024-105417},
abstract = {Background Radiofrequency ablation (RFA) is a common method for alleviating chronic back pain by targeting and ablating of facet joint sensory nerves. High-intensity focused ultrasound (HIFU) is an emerging, non-invasive, image-guided technology capable of providing thermal tissue ablation. While HIFU shows promise as a potentially superior option for ablating sensory nerves, its efficacy needs validation and comparison with existing methods.
Methods Nine adult pigs underwent fluoroscopy- guided HIFU ablation of eight lumbar medial branch nerves, with varying acoustic energy levels: 1000 (N=3), 1500 (N=3), or 2000 (N=3) joules (J). An additional three animals underwent standard RFA (two 90 s long lesions at 80°C) of the same eight nerves. Following 2 days of neurobehavioral observation, all 12 animals were sacrificed. The targeted tissue was excised and subjected to macropathology and micropathology, with a primary focus on the medial branch nerves.
Results The percentage of ablated nerves with HIFU was 71\%, 86\%, and 96\% for 1000 J, 1500 J, and 2000 J, respectively. In contrast, RFA achieved a 50\% ablation rate. No significant adverse events occurred during the procedure or follow-up period.
Conclusions These findings suggest that HIFU may be more effective than RFA in inducing thermal necrosis of the nerve.},
language = {en},
urldate = {2024-04-22},
journal = {Regional Anesthesia \& Pain Medicine},
author = {Gofeld, Michael and Tiennot, Thomas and Miller, Eric and Rebhun, Niv and Mobley, Stephen and Leblang, Suzanne and Aginsky, Ron and Hananel, Arik and Aubry, Jean-Francois},
month = mar,
year = {2024},
note = {1 citations (Crossref) [2024-04-25]},
pages = {rapm--2024--105417},
}
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{"_id":"TgAHC6EM9B7qss9vR","bibbaseid":"gofeld-tiennot-miller-rebhun-mobley-leblang-aginsky-hananel-etal-fluoroscopyguidedhighintensityfocusedultrasoundablationofthelumbarmedialbranchnervesdoseescalationstudyandcomparisonwithradiofrequencyablationinaporcinemodel-2024","author_short":["Gofeld, M.","Tiennot, T.","Miller, E.","Rebhun, N.","Mobley, S.","Leblang, S.","Aginsky, R.","Hananel, A.","Aubry, J."],"bibdata":{"bibtype":"article","type":"article","title":"Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves: dose escalation study and comparison with radiofrequency ablation in a porcine model","issn":"1098-7339, 1532-8651","shorttitle":"Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves","url":"https://rapm.bmj.com/lookup/doi/10.1136/rapm-2024-105417","doi":"10.1136/rapm-2024-105417","abstract":"Background Radiofrequency ablation (RFA) is a common method for alleviating chronic back pain by targeting and ablating of facet joint sensory nerves. High-intensity focused ultrasound (HIFU) is an emerging, non-invasive, image-guided technology capable of providing thermal tissue ablation. While HIFU shows promise as a potentially superior option for ablating sensory nerves, its efficacy needs validation and comparison with existing methods. Methods Nine adult pigs underwent fluoroscopy- guided HIFU ablation of eight lumbar medial branch nerves, with varying acoustic energy levels: 1000 (N=3), 1500 (N=3), or 2000 (N=3) joules (J). An additional three animals underwent standard RFA (two 90 s long lesions at 80°C) of the same eight nerves. Following 2 days of neurobehavioral observation, all 12 animals were sacrificed. The targeted tissue was excised and subjected to macropathology and micropathology, with a primary focus on the medial branch nerves. Results The percentage of ablated nerves with HIFU was 71%, 86%, and 96% for 1000 J, 1500 J, and 2000 J, respectively. In contrast, RFA achieved a 50% ablation rate. No significant adverse events occurred during the procedure or follow-up period. Conclusions These findings suggest that HIFU may be more effective than RFA in inducing thermal necrosis of the nerve.","language":"en","urldate":"2024-04-22","journal":"Regional Anesthesia & Pain Medicine","author":[{"propositions":[],"lastnames":["Gofeld"],"firstnames":["Michael"],"suffixes":[]},{"propositions":[],"lastnames":["Tiennot"],"firstnames":["Thomas"],"suffixes":[]},{"propositions":[],"lastnames":["Miller"],"firstnames":["Eric"],"suffixes":[]},{"propositions":[],"lastnames":["Rebhun"],"firstnames":["Niv"],"suffixes":[]},{"propositions":[],"lastnames":["Mobley"],"firstnames":["Stephen"],"suffixes":[]},{"propositions":[],"lastnames":["Leblang"],"firstnames":["Suzanne"],"suffixes":[]},{"propositions":[],"lastnames":["Aginsky"],"firstnames":["Ron"],"suffixes":[]},{"propositions":[],"lastnames":["Hananel"],"firstnames":["Arik"],"suffixes":[]},{"propositions":[],"lastnames":["Aubry"],"firstnames":["Jean-Francois"],"suffixes":[]}],"month":"March","year":"2024","note":"1 citations (Crossref) [2024-04-25]","pages":"rapm–2024–105417","bibtex":"@article{gofeld_fluoroscopy-guided_2024,\n\ttitle = {Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves: dose escalation study and comparison with radiofrequency ablation in a porcine model},\n\tissn = {1098-7339, 1532-8651},\n\tshorttitle = {Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves},\n\turl = {https://rapm.bmj.com/lookup/doi/10.1136/rapm-2024-105417},\n\tdoi = {10.1136/rapm-2024-105417},\n\tabstract = {Background Radiofrequency ablation (RFA) is a common method for alleviating chronic back pain by targeting and ablating of facet joint sensory nerves. High-intensity focused ultrasound (HIFU) is an emerging, non-invasive, image-guided technology capable of providing thermal tissue ablation. While HIFU shows promise as a potentially superior option for ablating sensory nerves, its efficacy needs validation and comparison with existing methods.\nMethods Nine adult pigs underwent fluoroscopy- guided HIFU ablation of eight lumbar medial branch nerves, with varying acoustic energy levels: 1000 (N=3), 1500 (N=3), or 2000 (N=3) joules (J). An additional three animals underwent standard RFA (two 90 s long lesions at 80°C) of the same eight nerves. Following 2 days of neurobehavioral observation, all 12 animals were sacrificed. The targeted tissue was excised and subjected to macropathology and micropathology, with a primary focus on the medial branch nerves.\nResults The percentage of ablated nerves with HIFU was 71\\%, 86\\%, and 96\\% for 1000 J, 1500 J, and 2000 J, respectively. In contrast, RFA achieved a 50\\% ablation rate. No significant adverse events occurred during the procedure or follow-up period.\nConclusions These findings suggest that HIFU may be more effective than RFA in inducing thermal necrosis of the nerve.},\n\tlanguage = {en},\n\turldate = {2024-04-22},\n\tjournal = {Regional Anesthesia \\& Pain Medicine},\n\tauthor = {Gofeld, Michael and Tiennot, Thomas and Miller, Eric and Rebhun, Niv and Mobley, Stephen and Leblang, Suzanne and Aginsky, Ron and Hananel, Arik and Aubry, Jean-Francois},\n\tmonth = mar,\n\tyear = {2024},\n\tnote = {1 citations (Crossref) [2024-04-25]},\n\tpages = {rapm--2024--105417},\n}\n\n\n\n","author_short":["Gofeld, M.","Tiennot, T.","Miller, E.","Rebhun, N.","Mobley, S.","Leblang, S.","Aginsky, R.","Hananel, A.","Aubry, J."],"key":"gofeld_fluoroscopy-guided_2024","id":"gofeld_fluoroscopy-guided_2024","bibbaseid":"gofeld-tiennot-miller-rebhun-mobley-leblang-aginsky-hananel-etal-fluoroscopyguidedhighintensityfocusedultrasoundablationofthelumbarmedialbranchnervesdoseescalationstudyandcomparisonwithradiofrequencyablationinaporcinemodel-2024","role":"author","urls":{"Paper":"https://rapm.bmj.com/lookup/doi/10.1136/rapm-2024-105417"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/zotero-group/webmaster-physmed/4989618 ","dataSources":["2zmHfMJTjh9nWweKf","z9W9wo2W8WdNKYzBC"],"keywords":[],"search_terms":["fluoroscopy","guided","high","intensity","focused","ultrasound","ablation","lumbar","medial","branch","nerves","dose","escalation","study","comparison","radiofrequency","ablation","porcine","model","gofeld","tiennot","miller","rebhun","mobley","leblang","aginsky","hananel","aubry"],"title":"Fluoroscopy-guided high-intensity focused ultrasound ablation of the lumbar medial branch nerves: dose escalation study and comparison with radiofrequency ablation in a porcine model","year":2024}