@article{gong_association_2023,
	title = {The association between quadriceps strength and synovitis in knee osteoarthritis: an exploratory study from the {Osteoarthritis} {Initiative}},
	volume = {50},
	copyright = {© 2023 The Journal of Rheumatology},
	issn = {0315-162X, 1499-2752},
	shorttitle = {The association between quadriceps strength and synovitis in knee osteoarthritis},
	url = {https://www.jrheum.org/content/early/2023/01/25/jrheum.220538},
	doi = {10.3899/jrheum.220538},
	abstract = {Objective The aim of this study was to explore the association between quadriceps strength and synovitis in knee osteoarthritis (KOA).
Methods This study was derived from the Osteoarthritis Initiative (OAI), which recruited adults from the OAI cohort with or at risk of KOA. Knees with complete records of isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments were included. Quadriceps strength was measured isometrically at baseline. Effusion-synovitis and Hoffa-synovitis were measured using the Magnetic Resonance Imaging Osteoarthritis Knee Score at baseline and at 1-year and 2-year follow-ups. Generalized estimating equations were used to analyze the associations of baseline quadriceps strength with changes in effusion-synovitis and Hoffa-synovitis in multivariable analyses. Additionally, analyses were stratified by synovitis-driven inflammatory phenotypes.
Results A total of 1513 knees were included in this study. In total, 61\% of the subjects were female; subjects had an average age of 61.9 (SD 8.8) years and a mean BMI of 29.4 (SD 4.7). Regarding the whole population, baseline quadriceps strength was negatively associated with baseline effusion-synovitis and follow-up changes in effusion-synovitis (odds ratio [OR] 0.77-0.86), but no significant association was observed in terms of Hoffa-synovitis. Stratified by synovitis-driven inflammatory phenotype, baseline quadriceps strength was significantly associated with follow-up changes in effusion-synovitis—but not in Hoffa-synovitis—in the population with existing effusion-synovitis (OR 0.75-0.79).
Conclusion Higher baseline quadriceps strength was negatively associated with changes in effusion-synovitis—but not in Hoffa-synovitis—especially in the population with existing effusion-synovitis. Our findings suggested a potential protective role of the quadriceps in effusion-synovitis.},
	language = {en},
	number = {4},
	urldate = {2023-02-02},
	journal = {The Journal of Rheumatology},
	author = {Gong, Ze and Li, Shengfa and Cao, Peihua and Ruan, Guangfeng and Zhang, Yan and Zeng, Qing and He, Zijun and Li, Shilin and Chen, Rong and Zheng, Peng and Fan, Tao and Lu, Pengcheng and Zhao, Yijin and Englund, Martin and Madry, Henning and Huang, Guozhi and Li, Le and Li, Jia and Ding, Changhai},
	month = apr,
	year = {2023},
	pmid = {36521912},
	note = {Number: 4
Publisher: The Journal of Rheumatology
Section: Article},
	pages = {548--555},
}

{"_id":"paMbDitXMCQ9L94YY","bibbaseid":"gong-li-cao-ruan-zhang-zeng-he-li-etal-theassociationbetweenquadricepsstrengthandsynovitisinkneeosteoarthritisanexploratorystudyfromtheosteoarthritisinitiative-2023","author_short":["Gong, Z.","Li, S.","Cao, P.","Ruan, G.","Zhang, Y.","Zeng, Q.","He, Z.","Li, S.","Chen, R.","Zheng, P.","Fan, T.","Lu, P.","Zhao, Y.","Englund, M.","Madry, H.","Huang, G.","Li, L.","Li, J.","Ding, C."],"bibdata":{"bibtype":"article","type":"article","title":"The association between quadriceps strength and synovitis in knee osteoarthritis: an exploratory study from the Osteoarthritis Initiative","volume":"50","copyright":"© 2023 The Journal of Rheumatology","issn":"0315-162X, 1499-2752","shorttitle":"The association between quadriceps strength and synovitis in knee osteoarthritis","url":"https://www.jrheum.org/content/early/2023/01/25/jrheum.220538","doi":"10.3899/jrheum.220538","abstract":"Objective The aim of this study was to explore the association between quadriceps strength and synovitis in knee osteoarthritis (KOA). Methods This study was derived from the Osteoarthritis Initiative (OAI), which recruited adults from the OAI cohort with or at risk of KOA. Knees with complete records of isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments were included. Quadriceps strength was measured isometrically at baseline. Effusion-synovitis and Hoffa-synovitis were measured using the Magnetic Resonance Imaging Osteoarthritis Knee Score at baseline and at 1-year and 2-year follow-ups. Generalized estimating equations were used to analyze the associations of baseline quadriceps strength with changes in effusion-synovitis and Hoffa-synovitis in multivariable analyses. Additionally, analyses were stratified by synovitis-driven inflammatory phenotypes. Results A total of 1513 knees were included in this study. In total, 61% of the subjects were female; subjects had an average age of 61.9 (SD 8.8) years and a mean BMI of 29.4 (SD 4.7). Regarding the whole population, baseline quadriceps strength was negatively associated with baseline effusion-synovitis and follow-up changes in effusion-synovitis (odds ratio [OR] 0.77-0.86), but no significant association was observed in terms of Hoffa-synovitis. Stratified by synovitis-driven inflammatory phenotype, baseline quadriceps strength was significantly associated with follow-up changes in effusion-synovitis—but not in Hoffa-synovitis—in the population with existing effusion-synovitis (OR 0.75-0.79). Conclusion Higher baseline quadriceps strength was negatively associated with changes in effusion-synovitis—but not in Hoffa-synovitis—especially in the population with existing effusion-synovitis. Our findings suggested a potential protective role of the quadriceps in effusion-synovitis.","language":"en","number":"4","urldate":"2023-02-02","journal":"The Journal of Rheumatology","author":[{"propositions":[],"lastnames":["Gong"],"firstnames":["Ze"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Shengfa"],"suffixes":[]},{"propositions":[],"lastnames":["Cao"],"firstnames":["Peihua"],"suffixes":[]},{"propositions":[],"lastnames":["Ruan"],"firstnames":["Guangfeng"],"suffixes":[]},{"propositions":[],"lastnames":["Zhang"],"firstnames":["Yan"],"suffixes":[]},{"propositions":[],"lastnames":["Zeng"],"firstnames":["Qing"],"suffixes":[]},{"propositions":[],"lastnames":["He"],"firstnames":["Zijun"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Shilin"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Rong"],"suffixes":[]},{"propositions":[],"lastnames":["Zheng"],"firstnames":["Peng"],"suffixes":[]},{"propositions":[],"lastnames":["Fan"],"firstnames":["Tao"],"suffixes":[]},{"propositions":[],"lastnames":["Lu"],"firstnames":["Pengcheng"],"suffixes":[]},{"propositions":[],"lastnames":["Zhao"],"firstnames":["Yijin"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Madry"],"firstnames":["Henning"],"suffixes":[]},{"propositions":[],"lastnames":["Huang"],"firstnames":["Guozhi"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Le"],"suffixes":[]},{"propositions":[],"lastnames":["Li"],"firstnames":["Jia"],"suffixes":[]},{"propositions":[],"lastnames":["Ding"],"firstnames":["Changhai"],"suffixes":[]}],"month":"April","year":"2023","pmid":"36521912","note":"Number: 4 Publisher: The Journal of Rheumatology Section: Article","pages":"548–555","bibtex":"@article{gong_association_2023,\n\ttitle = {The association between quadriceps strength and synovitis in knee osteoarthritis: an exploratory study from the {Osteoarthritis} {Initiative}},\n\tvolume = {50},\n\tcopyright = {© 2023 The Journal of Rheumatology},\n\tissn = {0315-162X, 1499-2752},\n\tshorttitle = {The association between quadriceps strength and synovitis in knee osteoarthritis},\n\turl = {https://www.jrheum.org/content/early/2023/01/25/jrheum.220538},\n\tdoi = {10.3899/jrheum.220538},\n\tabstract = {Objective The aim of this study was to explore the association between quadriceps strength and synovitis in knee osteoarthritis (KOA).\nMethods This study was derived from the Osteoarthritis Initiative (OAI), which recruited adults from the OAI cohort with or at risk of KOA. Knees with complete records of isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments were included. Quadriceps strength was measured isometrically at baseline. Effusion-synovitis and Hoffa-synovitis were measured using the Magnetic Resonance Imaging Osteoarthritis Knee Score at baseline and at 1-year and 2-year follow-ups. Generalized estimating equations were used to analyze the associations of baseline quadriceps strength with changes in effusion-synovitis and Hoffa-synovitis in multivariable analyses. Additionally, analyses were stratified by synovitis-driven inflammatory phenotypes.\nResults A total of 1513 knees were included in this study. In total, 61\\% of the subjects were female; subjects had an average age of 61.9 (SD 8.8) years and a mean BMI of 29.4 (SD 4.7). Regarding the whole population, baseline quadriceps strength was negatively associated with baseline effusion-synovitis and follow-up changes in effusion-synovitis (odds ratio [OR] 0.77-0.86), but no significant association was observed in terms of Hoffa-synovitis. Stratified by synovitis-driven inflammatory phenotype, baseline quadriceps strength was significantly associated with follow-up changes in effusion-synovitis—but not in Hoffa-synovitis—in the population with existing effusion-synovitis (OR 0.75-0.79).\nConclusion Higher baseline quadriceps strength was negatively associated with changes in effusion-synovitis—but not in Hoffa-synovitis—especially in the population with existing effusion-synovitis. Our findings suggested a potential protective role of the quadriceps in effusion-synovitis.},\n\tlanguage = {en},\n\tnumber = {4},\n\turldate = {2023-02-02},\n\tjournal = {The Journal of Rheumatology},\n\tauthor = {Gong, Ze and Li, Shengfa and Cao, Peihua and Ruan, Guangfeng and Zhang, Yan and Zeng, Qing and He, Zijun and Li, Shilin and Chen, Rong and Zheng, Peng and Fan, Tao and Lu, Pengcheng and Zhao, Yijin and Englund, Martin and Madry, Henning and Huang, Guozhi and Li, Le and Li, Jia and Ding, Changhai},\n\tmonth = apr,\n\tyear = {2023},\n\tpmid = {36521912},\n\tnote = {Number: 4\nPublisher: The Journal of Rheumatology\nSection: Article},\n\tpages = {548--555},\n}\n\n","author_short":["Gong, Z.","Li, S.","Cao, P.","Ruan, G.","Zhang, Y.","Zeng, Q.","He, Z.","Li, S.","Chen, R.","Zheng, P.","Fan, T.","Lu, P.","Zhao, Y.","Englund, M.","Madry, H.","Huang, G.","Li, L.","Li, J.","Ding, C."],"key":"gong_association_2023","id":"gong_association_2023","bibbaseid":"gong-li-cao-ruan-zhang-zeng-he-li-etal-theassociationbetweenquadricepsstrengthandsynovitisinkneeosteoarthritisanexploratorystudyfromtheosteoarthritisinitiative-2023","role":"author","urls":{"Paper":"https://www.jrheum.org/content/early/2023/01/25/jrheum.220538"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["LPTeGao77ndnG4Tks"],"keywords":[],"search_terms":["association","between","quadriceps","strength","synovitis","knee","osteoarthritis","exploratory","study","osteoarthritis","initiative","gong","li","cao","ruan","zhang","zeng","he","li","chen","zheng","fan","lu","zhao","englund","madry","huang","li","li","ding"],"title":"The association between quadriceps strength and synovitis in knee osteoarthritis: an exploratory study from the Osteoarthritis Initiative","year":2023}