@article{
 title = {Calmodulin inhibitors from aspergillus stromatoides},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 volume = {10},
 id = {36487a2e-1222-3ac3-9ffe-68a1b224156a},
 created = {2017-08-31T00:54:41.214Z},
 file_attached = {false},
 profile_id = {7da96f2b-cf05-3448-83f2-2c1e91a65514},
 last_modified = {2017-08-31T00:57:50.684Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {An organic extract was prepared from the culture medium and mycelia of the marine fungus Aspergillus stromatoides Raper  &  Fennell. The extract was fractionated via column chromatography, and the resulting fractions were tested for their abilities to quench the fluorescence of the calmodulin (CaM) biosensor hCaM M124C-mBBr. From the active fraction, emodin (1) and ω-hydroxyemodin (2) were isolated as CaM inhibitors. Anthraquinones 1 and 2 quenched the fluorescence of the hCaM M124C-mBBr biosensor in a concentration-dependent manner with K d  values of 0.33 and 0.76 μM, respectively. The results were compared with those of chlorpromazine (CPZ), a classical inhibitor of CaM, with a K d  value of 1.25 μM. Docking analysis revealed that 1 and 2 bind to the same pocket of CPZ. The CaM inhibitor properties of 1 and 2 were correlated with some of their reported biological properties. Citrinin (3), methyl 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (4), and coniochaetone A (5) were also isolated in the present study. The X-ray structure of 5 is reported for the first time. Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.},
 bibtype = {article},
 author = {González-Andrade, M. and Del Valle, P. and Macías-Rubalcava, M.L. and Sosa-Peinado, A. and Del Carmen González, M. and Mata, R.},
 journal = {Chemistry and Biodiversity},
 number = {3}
}

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