Genetics of vasculitis. González-Gay, M. Á., Heras-Recuero, E., Blázquez-Sánchez, T., Caraballo-Salazar, C., Rengifo-García, F., Castañeda, S., Martín, J., Marquez, A., & Largo, R. Best practice & research. Clinical rheumatology, July, 2024. Place: Netherlandsdoi abstract bibtex Systemic vasculitis encompasses a wide range of conditions characterized by varying degrees of inflammation in blood vessels. Although the etiology of vasculitis remains unclear, accumulated data suggest that it is triggered in genetically predisposed individuals by the concurrence of certain environmental factors. The importance of the genetic component has been consistently supported by evidence of familial aggregation, differential prevalence by ethnicity, and multiple genetic associations with disease susceptibility and severity reported in recent years. The strongest association signals in most vasculitides correspond to genetic variants within the HLA region, suggesting an important role of the immune system in its pathophysiology. However, each type of vasculitis has distinct defining HLA association markers, likely due to disease-specific differences in antigenic drivers. Furthermore, other genetic polymorphisms located outside the HLA region play an important role in susceptibility to different vasculitides. More recent research has assessed the shared genetic susceptibility evident across different vasculitides. Future studies should focus on the identification of genetic markers that can serve as reliable biomarkers for early diagnosis, prognosis, and treatment response in systemic vasculitis.
@article{gonzalez-gay_genetics_2024,
title = {Genetics of vasculitis.},
copyright = {Copyright © 2024. Published by Elsevier Ltd.},
issn = {1532-1770 1521-6942},
doi = {10.1016/j.berh.2024.101969},
abstract = {Systemic vasculitis encompasses a wide range of conditions characterized by varying degrees of inflammation in blood vessels. Although the etiology of vasculitis remains unclear, accumulated data suggest that it is triggered in genetically predisposed individuals by the concurrence of certain environmental factors. The importance of the genetic component has been consistently supported by evidence of familial aggregation, differential prevalence by ethnicity, and multiple genetic associations with disease susceptibility and severity reported in recent years. The strongest association signals in most vasculitides correspond to genetic variants within the HLA region, suggesting an important role of the immune system in its pathophysiology. However, each type of vasculitis has distinct defining HLA association markers, likely due to disease-specific differences in antigenic drivers. Furthermore, other genetic polymorphisms located outside the HLA region play an important role in susceptibility to different vasculitides. More recent research has assessed the shared genetic susceptibility evident across different vasculitides. Future studies should focus on the identification of genetic markers that can serve as reliable biomarkers for early diagnosis, prognosis, and treatment response in systemic vasculitis.},
language = {eng},
journal = {Best practice \& research. Clinical rheumatology},
author = {González-Gay, Miguel Ángel and Heras-Recuero, Elena and Blázquez-Sánchez, Teresa and Caraballo-Salazar, Claritza and Rengifo-García, Fernando and Castañeda, Santos and Martín, Javier and Marquez, Ana and Largo, Raquel},
month = jul,
year = {2024},
pmid = {38955656},
note = {Place: Netherlands},
keywords = {ANCA-Associated vasculitis, Behçet disease, Genetics, Giant cell arteritis, IgA vasculitis, Kawasaki disease, Polyarteritis nodosa, Systemic vasculitis, Takayasu arteritis},
pages = {101969},
}
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The importance of the genetic component has been consistently supported by evidence of familial aggregation, differential prevalence by ethnicity, and multiple genetic associations with disease susceptibility and severity reported in recent years. The strongest association signals in most vasculitides correspond to genetic variants within the HLA region, suggesting an important role of the immune system in its pathophysiology. However, each type of vasculitis has distinct defining HLA association markers, likely due to disease-specific differences in antigenic drivers. Furthermore, other genetic polymorphisms located outside the HLA region play an important role in susceptibility to different vasculitides. More recent research has assessed the shared genetic susceptibility evident across different vasculitides. 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