The cost-utility of rotavirus vaccination with Rotarix™ (RIX4414) in the Netherlands. Goossens, L. M. A., Standaert, B., Hartwig, N., Hövels, A. M., & Al, M. J. Vaccine, 26(8):1118–1127, February, 2008.
The cost-utility of rotavirus vaccination with Rotarix™ (RIX4414) in the Netherlands [link]Paper  doi  abstract   bibtex   
Summary The objective of this study was to estimate the cost-utility of mass vaccination of 0–4-year-old children with Rotarix™ in the Netherlands. We used a Markov process with Dutch data on incidence, resource use and costs (GP, hospitalisation, productivity loss and household costs) to compare vaccination to conventional treatment from a societal perspective. Utility loss due to rotavirus-induced diarrhoea was measured using EQ5D, with GPs and paediatricians serving as proxies to fill out the questions. As the costs of a vaccination course ranged from €90 to €100 per child, the cost-utility ratio varied from €21,900 to €35,076 per QALY gained. Based on the current study, it is clear that mass vaccination with Rotarix™ against rotavirus gastroenteritis can be attractive, from an economic and a health care perspective.
@article{goossens_cost-utility_2008,
	title = {The cost-utility of rotavirus vaccination with {Rotarix}™ ({RIX4414}) in the {Netherlands}},
	volume = {26},
	issn = {0264-410X},
	url = {http://www.sciencedirect.com/science/article/pii/S0264410X07013564},
	doi = {10.1016/j.vaccine.2007.11.070},
	abstract = {Summary
The objective of this study was to estimate the cost-utility of mass vaccination of 0–4-year-old children with Rotarix™ in the Netherlands. We used a Markov process with Dutch data on incidence, resource use and costs (GP, hospitalisation, productivity loss and household costs) to compare vaccination to conventional treatment from a societal perspective. Utility loss due to rotavirus-induced diarrhoea was measured using EQ5D, with GPs and paediatricians serving as proxies to fill out the questions. As the costs of a vaccination course ranged from €90 to €100 per child, the cost-utility ratio varied from €21,900 to €35,076 per QALY gained. Based on the current study, it is clear that mass vaccination with Rotarix™ against rotavirus gastroenteritis can be attractive, from an economic and a health care perspective.},
	number = {8},
	urldate = {2015-03-03},
	journal = {Vaccine},
	author = {Goossens, Lucas M. A. and Standaert, Baudouin and Hartwig, Nico and Hövels, Anke M. and Al, Maiwenn J.},
	month = feb,
	year = {2008},
	pages = {1118--1127},
}

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