Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress. Gorka, A. X, Hanson, J. L, Radtke, S. R, & Hariri, A. R Biol. Mood Anxiety Disord., 4:12, November, 2014. 00000Paper doi abstract bibtex BACKGROUND: The experience of early life stress is a consistently identified risk factor for the development of mood and anxiety disorders. Preclinical research employing animal models of early life stress has made inroads in understanding this association and suggests that the negative sequelae of early life stress may be mediated by developmental disruption of corticolimbic structures supporting stress responsiveness. Work in humans has corroborated this idea, as childhood adversity has been associated with alterations in gray matter volumes of the hippocampus, amygdala, and medial prefrontal cortex. Yet, missing from this body of research is a full understanding of how these neurobiological vulnerabilities may mechanistically contribute to the reported link between adverse childhood experiences and later affective psychopathology. RESULTS: Analyses revealed that self-reported childhood maltreatment was associated with reduced gray matter volumes within the medial prefrontal cortex and left hippocampus. Furthermore, reduced left hippocampal and medial prefrontal gray matter volume mediated the relationship between childhood maltreatment and trait anxiety. Additionally, individual differences in corticolimbic gray matter volume within these same structures predicted the anxious symptoms as a function of life stress 1 year after initial assessment. CONCLUSIONS: Collectively, these findings provide novel evidence that reductions in corticolimbic gray matter, particularly within the hippocampus and medial prefrontal cortex, are associated with reported childhood maltreatment and individual differences in adult trait anxiety. Furthermore, our results suggest that these structural alterations contribute to increased affective sensitivity to stress later in life in those that have experienced early adversity. More broadly, the findings contribute to an emerging literature highlighting the critical importance of early stress on the development of corticolimbic structures supporting adaptive functioning later in life.
@article{gorka_reduced_2014,
title = {Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress},
volume = {4},
issn = {2045-5380},
url = {http://dx.doi.org/10.1186/2045-5380-4-12},
doi = {10.1186/2045-5380-4-12},
abstract = {BACKGROUND: The experience of early life stress is a consistently
identified risk factor for the development of mood and anxiety disorders.
Preclinical research employing animal models of early life stress has made
inroads in understanding this association and suggests that the negative
sequelae of early life stress may be mediated by developmental disruption
of corticolimbic structures supporting stress responsiveness. Work in
humans has corroborated this idea, as childhood adversity has been
associated with alterations in gray matter volumes of the hippocampus,
amygdala, and medial prefrontal cortex. Yet, missing from this body of
research is a full understanding of how these neurobiological
vulnerabilities may mechanistically contribute to the reported link
between adverse childhood experiences and later affective psychopathology.
RESULTS: Analyses revealed that self-reported childhood maltreatment was
associated with reduced gray matter volumes within the medial prefrontal
cortex and left hippocampus. Furthermore, reduced left hippocampal and
medial prefrontal gray matter volume mediated the relationship between
childhood maltreatment and trait anxiety. Additionally, individual
differences in corticolimbic gray matter volume within these same
structures predicted the anxious symptoms as a function of life stress 1
year after initial assessment. CONCLUSIONS: Collectively, these findings
provide novel evidence that reductions in corticolimbic gray matter,
particularly within the hippocampus and medial prefrontal cortex, are
associated with reported childhood maltreatment and individual differences
in adult trait anxiety. Furthermore, our results suggest that these
structural alterations contribute to increased affective sensitivity to
stress later in life in those that have experienced early adversity. More
broadly, the findings contribute to an emerging literature highlighting
the critical importance of early stress on the development of
corticolimbic structures supporting adaptive functioning later in life.},
journal = {Biol. Mood Anxiety Disord.},
author = {Gorka, Adam X and Hanson, Jamie L and Radtke, Spenser R and Hariri, Ahmad R},
month = nov,
year = {2014},
note = {00000},
keywords = {Anxiety, Childhood maltreatment, Gray matter, Hippocampus, MRI, Medial prefrontal cortex, Sep 20 import, Stress, duplicate},
pages = {12}
}
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R"],"year":2014,"bibtype":"article","biburl":"https://bibbase.org/zotero/davidlloyd33","bibdata":{"bibtype":"article","type":"article","title":"Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress","volume":"4","issn":"2045-5380","url":"http://dx.doi.org/10.1186/2045-5380-4-12","doi":"10.1186/2045-5380-4-12","abstract":"BACKGROUND: The experience of early life stress is a consistently identified risk factor for the development of mood and anxiety disorders. Preclinical research employing animal models of early life stress has made inroads in understanding this association and suggests that the negative sequelae of early life stress may be mediated by developmental disruption of corticolimbic structures supporting stress responsiveness. Work in humans has corroborated this idea, as childhood adversity has been associated with alterations in gray matter volumes of the hippocampus, amygdala, and medial prefrontal cortex. Yet, missing from this body of research is a full understanding of how these neurobiological vulnerabilities may mechanistically contribute to the reported link between adverse childhood experiences and later affective psychopathology. RESULTS: Analyses revealed that self-reported childhood maltreatment was associated with reduced gray matter volumes within the medial prefrontal cortex and left hippocampus. Furthermore, reduced left hippocampal and medial prefrontal gray matter volume mediated the relationship between childhood maltreatment and trait anxiety. Additionally, individual differences in corticolimbic gray matter volume within these same structures predicted the anxious symptoms as a function of life stress 1 year after initial assessment. CONCLUSIONS: Collectively, these findings provide novel evidence that reductions in corticolimbic gray matter, particularly within the hippocampus and medial prefrontal cortex, are associated with reported childhood maltreatment and individual differences in adult trait anxiety. Furthermore, our results suggest that these structural alterations contribute to increased affective sensitivity to stress later in life in those that have experienced early adversity. More broadly, the findings contribute to an emerging literature highlighting the critical importance of early stress on the development of corticolimbic structures supporting adaptive functioning later in life.","journal":"Biol. Mood Anxiety Disord.","author":[{"propositions":[],"lastnames":["Gorka"],"firstnames":["Adam","X"],"suffixes":[]},{"propositions":[],"lastnames":["Hanson"],"firstnames":["Jamie","L"],"suffixes":[]},{"propositions":[],"lastnames":["Radtke"],"firstnames":["Spenser","R"],"suffixes":[]},{"propositions":[],"lastnames":["Hariri"],"firstnames":["Ahmad","R"],"suffixes":[]}],"month":"November","year":"2014","note":"00000","keywords":"Anxiety, Childhood maltreatment, Gray matter, Hippocampus, MRI, Medial prefrontal cortex, Sep 20 import, Stress, duplicate","pages":"12","bibtex":"@article{gorka_reduced_2014,\n\ttitle = {Reduced hippocampal and medial prefrontal gray matter mediate the association between reported childhood maltreatment and trait anxiety in adulthood and predict sensitivity to future life stress},\n\tvolume = {4},\n\tissn = {2045-5380},\n\turl = {http://dx.doi.org/10.1186/2045-5380-4-12},\n\tdoi = {10.1186/2045-5380-4-12},\n\tabstract = {BACKGROUND: The experience of early life stress is a consistently\nidentified risk factor for the development of mood and anxiety disorders.\nPreclinical research employing animal models of early life stress has made\ninroads in understanding this association and suggests that the negative\nsequelae of early life stress may be mediated by developmental disruption\nof corticolimbic structures supporting stress responsiveness. Work in\nhumans has corroborated this idea, as childhood adversity has been\nassociated with alterations in gray matter volumes of the hippocampus,\namygdala, and medial prefrontal cortex. Yet, missing from this body of\nresearch is a full understanding of how these neurobiological\nvulnerabilities may mechanistically contribute to the reported link\nbetween adverse childhood experiences and later affective psychopathology.\nRESULTS: Analyses revealed that self-reported childhood maltreatment was\nassociated with reduced gray matter volumes within the medial prefrontal\ncortex and left hippocampus. Furthermore, reduced left hippocampal and\nmedial prefrontal gray matter volume mediated the relationship between\nchildhood maltreatment and trait anxiety. Additionally, individual\ndifferences in corticolimbic gray matter volume within these same\nstructures predicted the anxious symptoms as a function of life stress 1\nyear after initial assessment. CONCLUSIONS: Collectively, these findings\nprovide novel evidence that reductions in corticolimbic gray matter,\nparticularly within the hippocampus and medial prefrontal cortex, are\nassociated with reported childhood maltreatment and individual differences\nin adult trait anxiety. Furthermore, our results suggest that these\nstructural alterations contribute to increased affective sensitivity to\nstress later in life in those that have experienced early adversity. More\nbroadly, the findings contribute to an emerging literature highlighting\nthe critical importance of early stress on the development of\ncorticolimbic structures supporting adaptive functioning later in life.},\n\tjournal = {Biol. 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