@article{
 title = {Evolution of RXLR-Class Effectors in the Oomycete Plant Pathogen Phytophthora ramorum},
 type = {article},
 year = {2013},
 identifiers = {[object Object]},
 volume = {8},
 month = {11},
 id = {3814b7e0-f2a1-3344-a337-7d19ac47a17e},
 created = {2016-09-30T15:56:40.000Z},
 file_attached = {false},
 profile_id = {d68e4e2d-8d57-381f-a508-bc083be49199},
 last_modified = {2016-09-30T15:56:40.000Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {true},
 hidden = {false},
 citation_key = {ISI:000327162900038},
 source_type = {article},
 abstract = {Phytophthora plant pathogens contain many hundreds of effectors
potentially involved in infection of host plants. Comparative genomic
analyses have shown that these effectors evolve rapidly and have been
subject to recent expansions. We examined the recent sequence evolution
of RXLR-class effector gene families in the sudden oak death pathogen,
P. ramorum. We found that P. ramorum RXLR effectors have taken multiple
evolutionary paths, including loss or gain of repeated domains,
recombination or gene conversion among paralogs, and selection on point
mutations. Sequencing of homologs from two subfamilies in P. ramorum's
closest known relatives revealed repeated gene duplication and
divergence since speciation with P. lateralis. One family showed strong
signatures of recombination while the other family has evolved primarily
by point mutation. Comparison of a small number of the hundreds of
RXLR-class effectors across three clonal lineages of P. ramorum shows
striking divergence in alleles among lineages, suggesting the potential
for functional differences between lineages. Our results suggest future
avenues for examination of rapidly evolving effectors in P. ramorum,
including investigation of the functional and coevolutionary
significance of the patterns of sequence evolution that we observed.},
 bibtype = {article},
 author = {Goss, Erica M and Press, Caroline M and Grünwald, Niklaus J.},
 journal = {PLOS ONE},
 number = {11}
}

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