Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders. Goto, Y., Yang, C. R, & Otani, S. Biol. Psychiatry, 67(3):199--207, February, 2010. 00000
Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders [link]Paper  doi  abstract   bibtex   
Prefrontal cortex (PFC) mediates an assortment of cognitive functions including working memory, behavioral flexibility, attention, and future planning. Unlike the hippocampus, where induction of synaptic plasticity in the network is well-documented in relation to long-term memory, cognitive functions mediated by the PFC have been thought to be independent of long-lasting neuronal adaptation of the network. Nonetheless, accumulating evidence suggests that prefrontal cortical neurons possess the cellular machinery of synaptic plasticity and exhibit lasting changes of neural activity associated with various cognitive processes. Moreover, deficits in the mechanisms of synaptic plasticity induction in the PFC might be involved in the pathophysiology of psychiatric and neurological disorders such as schizophrenia, drug addiction, mood disorders, and Alzheimer's disease.
@article{goto_functional_2010,
	title = {Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders},
	volume = {67},
	issn = {0006-3223},
	url = {http://dx.doi.org/10.1016/j.biopsych.2009.08.026},
	doi = {10.1016/j.biopsych.2009.08.026},
	abstract = {Prefrontal cortex (PFC) mediates an assortment of cognitive functions
including working memory, behavioral flexibility, attention, and future
planning. Unlike the hippocampus, where induction of synaptic plasticity
in the network is well-documented in relation to long-term memory,
cognitive functions mediated by the PFC have been thought to be
independent of long-lasting neuronal adaptation of the network.
Nonetheless, accumulating evidence suggests that prefrontal cortical
neurons possess the cellular machinery of synaptic plasticity and exhibit
lasting changes of neural activity associated with various cognitive
processes. Moreover, deficits in the mechanisms of synaptic plasticity
induction in the PFC might be involved in the pathophysiology of
psychiatric and neurological disorders such as schizophrenia, drug
addiction, mood disorders, and Alzheimer's disease.},
	number = {3},
	journal = {Biol. Psychiatry},
	author = {Goto, Yukiori and Yang, Charles R and Otani, Satoru},
	month = feb,
	year = {2010},
	note = {00000},
	keywords = {Sep 20 import, duplicate},
	pages = {199--207}
}

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