Optical pH Sensor Covering the Range from pH 0-14 Compatible with Mobile-Device Readout and Based on a Set of Rationally Designed Indicator Dyes. Gotor, R., Ashokkumar, P., Hech, M., Keil, K., & Rurack, K. ANALYTICAL CHEMISTRY, 89(16):8437-8444, AUG 15, 2017. doi abstract bibtex In this work, a family of pH-responsive fluorescent probes has been designed in a rational manner with the aid of quantum chemistry tools, covering the entire pH range from 0-14. Relying on the boron-dipyrromethene (BODIPY) core, all the probes as well as selected reference dyes display very similar spectroscopic properties with ON OFF fluorescence switching responses, facilitating optical readout in simple devices used for detection and analysis. Embedding of the probes and reference dyes into hydrogel spots on a plastic strip yielded a test strip that reversibly indicates pH with a considerably small uncertainty of similar to 0.1 pH units. These strips are not only reusable but, combined with a 3D-printed case that can be attached to a smartphone, the USB port of which drives the integrated LED used for excitation, allows for autonomous operation in on-site or in-the-field applications; the developed Android application software (''app'') further simplifies operation for unskilled users.
@article{ ISI:000407988600037,
Author = {Gotor, Raul and Ashokkumar, Pichandi and Hech, Mandy and Keil, Karin and
Rurack, Knut},
Title = {{Optical pH Sensor Covering the Range from pH 0-14 Compatible with
Mobile-Device Readout and Based on a Set of Rationally Designed
Indicator Dyes}},
Journal = {{ANALYTICAL CHEMISTRY}},
Year = {{2017}},
Volume = {{89}},
Number = {{16}},
Pages = {{8437-8444}},
Month = {{AUG 15}},
Abstract = {{In this work, a family of pH-responsive fluorescent probes has been
designed in a rational manner with the aid of quantum chemistry tools,
covering the entire pH range from 0-14. Relying on the
boron-dipyrromethene (BODIPY) core, all the probes as well as selected
reference dyes display very similar spectroscopic properties with ON OFF
fluorescence switching responses, facilitating optical readout in simple
devices used for detection and analysis. Embedding of the probes and
reference dyes into hydrogel spots on a plastic strip yielded a test
strip that reversibly indicates pH with a considerably small uncertainty
of similar to 0.1 pH units. These strips are not only reusable but,
combined with a 3D-printed case that can be attached to a smartphone,
the USB port of which drives the integrated LED used for excitation,
allows for autonomous operation in on-site or in-the-field applications;
the developed Android application software ({''}app{''}) further
simplifies operation for unskilled users.}},
DOI = {{10.1021/acs.analchem.7b01903}},
ISSN = {{0003-2700}},
EISSN = {{1520-6882}},
ResearcherID-Numbers = {{Ashokkumar, Pichandi/F-9802-2010}},
ORCID-Numbers = {{Ashokkumar, Pichandi/0000-0002-2505-9039}},
Unique-ID = {{ISI:000407988600037}},
}
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