@article{
 title = {A strategy to exploit surrogate sire technology in livestock breeding programs},
 type = {article},
 year = {2017},
 websites = {http://biorxiv.org/content/early/2017/10/07/199893.abstract},
 month = {1},
 day = {1},
 id = {69b3e830-820a-3c86-95ca-d568af97d42a},
 created = {2018-05-03T12:05:19.855Z},
 file_attached = {false},
 profile_id = {9ca27882-2561-35ad-83fc-979e45a13e32},
 group_id = {6e40dffa-27af-331f-992a-70c68bd0c7e9},
 last_modified = {2018-05-03T12:05:19.855Z},
 read = {false},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 source_type = {JOUR},
 private_publication = {false},
 abstract = {Background: In this work, we performed simulations to develop and test a strategy for exploiting surrogate sire technology in livestock breeding programs. Methods: One hundred replicates of various scenarios were performed. Scenarios followed a common overall structure but differed in the strategy used to identify elite donors and how these donors were used in the product development part. Results: The results of this study showed that using surrogate sire technology would significantly increase the genetic merit of commercial sires, by as much as 6.5 to 9.2 years worth of genetic gain compared to a conventional breeding program. The simulations suggested that an identification strategy involving three-stages, the first of which uses genomic selection while the subsequent stages use progeny testing was the most effective strategy of all of those tested. Conclusions: The use of one or a handful of elite donors to generate the production animals would be very different to current practice. While the results demonstrate the great potential of surrogate sire technology there are considerable risks but also other opportunities. Practical implementation of surrogate sire technology would need to account for these.},
 bibtype = {article},
 author = {Gottardo, Paolo and Gorjanc, Gregor and Battagin, Mara and Gaynor, Chris Robert and Jenko, Janez and Freixedes, Roger Ros and Whitelaw, Bruce and Mileham, Alan and Herring, William and Hickey, John},
 journal = {bioRxiv}
}

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Methods: One hundred replicates of various scenarios were performed. Scenarios followed a common overall structure but differed in the strategy used to identify elite donors and how these donors were used in the product development part. Results: The results of this study showed that using surrogate sire technology would significantly increase the genetic merit of commercial sires, by as much as 6.5 to 9.2 years worth of genetic gain compared to a conventional breeding program. The simulations suggested that an identification strategy involving three-stages, the first of which uses genomic selection while the subsequent stages use progeny testing was the most effective strategy of all of those tested. Conclusions: The use of one or a handful of elite donors to generate the production animals would be very different to current practice. While the results demonstrate the great potential of surrogate sire technology there are considerable risks but also other opportunities. Practical implementation of surrogate sire technology would need to account for these.","bibtype":"article","author":"Gottardo, Paolo and Gorjanc, Gregor and Battagin, Mara and Gaynor, Chris Robert and Jenko, Janez and Freixedes, Roger Ros and Whitelaw, Bruce and Mileham, Alan and Herring, William and Hickey, John","journal":"bioRxiv","bibtex":"@article{\n title = {A strategy to exploit surrogate sire technology in livestock breeding programs},\n type = {article},\n year = {2017},\n websites = {http://biorxiv.org/content/early/2017/10/07/199893.abstract},\n month = {1},\n day = {1},\n id = {69b3e830-820a-3c86-95ca-d568af97d42a},\n created = {2018-05-03T12:05:19.855Z},\n file_attached = {false},\n profile_id = {9ca27882-2561-35ad-83fc-979e45a13e32},\n group_id = {6e40dffa-27af-331f-992a-70c68bd0c7e9},\n last_modified = {2018-05-03T12:05:19.855Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n source_type = {JOUR},\n private_publication = {false},\n abstract = {Background: In this work, we performed simulations to develop and test a strategy for exploiting surrogate sire technology in livestock breeding programs. Methods: One hundred replicates of various scenarios were performed. Scenarios followed a common overall structure but differed in the strategy used to identify elite donors and how these donors were used in the product development part. Results: The results of this study showed that using surrogate sire technology would significantly increase the genetic merit of commercial sires, by as much as 6.5 to 9.2 years worth of genetic gain compared to a conventional breeding program. The simulations suggested that an identification strategy involving three-stages, the first of which uses genomic selection while the subsequent stages use progeny testing was the most effective strategy of all of those tested. Conclusions: The use of one or a handful of elite donors to generate the production animals would be very different to current practice. While the results demonstrate the great potential of surrogate sire technology there are considerable risks but also other opportunities. 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