Understanding variability in the BOLD signal and why it matters for aging. Grady, C., L. & Garrett, D., D. 2014.
Understanding variability in the BOLD signal and why it matters for aging [pdf]Paper  abstract   bibtex   
Recent work in neuroscience supports the idea that variability in brain function is necessary for optimal brain responsivity to a changing environment. In this review, we discuss a series of functional magnetic resonance imaging (fMRI) studies in younger and older adults to assess age-related differences in variability of the fMRI signal. This work shows that moment-to-moment brain signal variability represents an important "signal" within what is typically considered measurement-related "noise" in fMRI. This accumulation of evidence suggests that moving beyond the mean will provide a complementary window into aging-related neural processes.

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