Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos. Graff, M., Emery, L. S, Justice, A. E, Parra, E., Below, J. E, Palmer, N. D, Gao, C., Duan, Q., Valladares-Salgado, A., Cruz, M., Morrison, A. C, Boerwinkle, E., Whitsel, E. A, Kooperberg, C., Reiner, A., Li, Y., Rodriguez, C. J., Talavera, G. A, Langefeld, C. D, Wagenknecht, L. E, Norris, J. M, Taylor, K. D, Papanicolaou, G., Kenny, E., Loos, R. J F, Chen, Y. I., Laurie, C., Sofer, T., & North, K. E Lipids Health Dis, 16(1):200, Oct, 2017.
Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos [link]Paper  doi  abstract   bibtex   
BACKGROUND: Despite ethnic disparities in lipid profiles, there are few genome-wide association studies investigating genetic variation of lipids in non-European ancestry populations. In this study, we present findings from genetic association analyses for total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides in a large Hispanic/Latino cohort in the U.S., the Hispanic Community Health Study / Study of Latinos (HCHS/SOL). METHODS: We estimated a heritability of approximately 20% for each lipid trait, similar to previous estimates in Europeans. To search for novel lipid loci, we performed conditional association analysis in which the statistical model was adjusted for previously reported SNPs associated with any of the four lipid traits. SNPs that remained genome-wide significant (P < 5 × 10-8) after conditioning on known loci were evaluated for replication. RESULTS: We identified eight potentially novel lipid signals with minor allele frequencies <1%, none of which replicated. We tested previously reported SNP-trait associations for generalization to Hispanics/Latinos via a statistical framework. The generalization analysis revealed that approximately 50% of previously established lipid variants generalize to HCHS/SOL based on directional FDR r-value < 0.05. Some failures to generalize were due to lack of power. CONCLUSIONS: These results demonstrate that many loci associated with lipid levels are shared across populations.
@article{Graff:2017aa,
	abstract = {BACKGROUND: Despite ethnic disparities in lipid profiles, there are few genome-wide association studies investigating genetic variation of lipids in non-European ancestry populations. In this study, we present findings from genetic association analyses for total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides in a large Hispanic/Latino cohort in the U.S., the Hispanic Community Health Study / Study of Latinos (HCHS/SOL).
METHODS: We estimated a heritability of approximately 20% for each lipid trait, similar to previous estimates in Europeans. To search for novel lipid loci, we performed conditional association analysis in which the statistical model was adjusted for previously reported SNPs associated with any of the four lipid traits. SNPs that remained genome-wide significant (P < 5 × 10-8) after conditioning on known loci were evaluated for replication.
RESULTS: We identified eight potentially novel lipid signals with minor allele frequencies <1%, none of which replicated. We tested previously reported SNP-trait associations for generalization to Hispanics/Latinos via a statistical framework. The generalization analysis revealed that approximately 50% of previously established lipid variants generalize to HCHS/SOL based on directional FDR r-value < 0.05. Some failures to generalize were due to lack of power.
CONCLUSIONS: These results demonstrate that many loci associated with lipid levels are shared across populations.},
	author = {Graff, Mariaelisa and Emery, Leslie S and Justice, Anne E and Parra, Esteban and Below, Jennifer E and Palmer, Nicholette D and Gao, Chuan and Duan, Qing and Valladares-Salgado, Adan and Cruz, Miguel and Morrison, Alanna C and Boerwinkle, Eric and Whitsel, Eric A and Kooperberg, Charles and Reiner, Alex and Li, Yun and Rodriguez, Carlos Jose and Talavera, Gregory A and Langefeld, Carl D and Wagenknecht, Lynne E and Norris, Jill M and Taylor, Kent D and Papanicolaou, George and Kenny, Eimear and Loos, Ruth J F and Chen, Yii-Der Ida and Laurie, Cathy and Sofer, Tamar and North, Kari E},
	date-added = {2024-05-19 21:02:24 -0400},
	date-modified = {2024-05-19 21:02:24 -0400},
	doi = {10.1186/s12944-017-0591-6},
	journal = {Lipids Health Dis},
	journal-full = {Lipids in health and disease},
	keywords = {Ancestry; Cholesterol; Genetics; HDL; Hispanic/Latino; LDL; Triglycerides},
	mesh = {Adolescent; Adult; Aged; Alleles; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Female; Gene Frequency; Genetic Loci; Genome, Human; Genome-Wide Association Study; Genotype; Hispanic or Latino; Humans; Lipid Metabolism; Male; Middle Aged; Polymorphism, Single Nucleotide; Public Health; Quantitative Trait, Heritable; Triglycerides; United States},
	month = {Oct},
	number = {1},
	pages = {200},
	pmc = {PMC5639746},
	pmid = {29025430},
	url = {https://pubmed.ncbi.nlm.nih.gov/29025430/},
	pst = {epublish},
	title = {Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos},
	volume = {16},
	year = {2017},
	bdsk-url-1 = {https://doi.org/10.1186/s12944-017-0591-6}}
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