@article{RN133,
   author = {Graybill, P. M. and Davalos, R. V.},
   title = {Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies},
   journal = {Cancers (Basel)},
   volume = {12},
   number = {5},
   note = {2072-6694
Graybill, Philip M
Orcid: 0000-0002-2057-7478
Davalos, Rafael V
Orcid: 0000-0003-1503-9509
P01 CA207206/CA/NCI NIH HHS/United States
P01CA207206/NH/NIH HHS/United States
Journal Article
Review
Switzerland
2020/05/06
Cancers (Basel). 2020 Apr 30;12(5):1132. doi: 10.3390/cancers12051132.},
   abstract = {Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase the permeability of cell membranes, a phenomenon known as electroporation. In addition to well-known membrane effects, PEFs can cause profound cytoskeletal disruption. In this review, we summarize the current understanding of cytoskeletal disruption after PEFs. Compiling available studies, we describe PEF-induced cytoskeletal disruption and possible mechanisms of disruption. Additionally, we consider how cytoskeletal alterations contribute to cell-cell and cell-substrate disruption. We conclude with a discussion of cytoskeletal disruption-induced anti-vascular effects of PEFs and consider how a better understanding of cytoskeletal disruption after PEFs may lead to more effective therapies.},
   keywords = {Ect
Ire
actin
cancer
cell junctions
cytoskeleton
electroporation
intermediate filaments
mechanobiology
microtubules
nsPEFs
pulsed electric fields
vascular lock},
   ISSN = {2072-6694 (Print)
2072-6694},
   DOI = {10.3390/cancers12051132},
   year = {2020},
   type = {Journal Article}
}

{"_id":"5rc9tfM7cJFWjfcTx","bibbaseid":"graybill-davalos-cytoskeletaldisruptionafterelectroporationanditssignificancetopulsedelectricfieldtherapies-2020","author_short":["Graybill, P. M.","Davalos, R. V."],"bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Graybill"],"firstnames":["P.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Davalos"],"firstnames":["R.","V."],"suffixes":[]}],"title":"Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies","journal":"Cancers (Basel)","volume":"12","number":"5","note":"2072-6694 Graybill, Philip M Orcid: 0000-0002-2057-7478 Davalos, Rafael V Orcid: 0000-0003-1503-9509 P01 CA207206/CA/NCI NIH HHS/United States P01CA207206/NH/NIH HHS/United States Journal Article Review Switzerland 2020/05/06 Cancers (Basel). 2020 Apr 30;12(5):1132. doi: 10.3390/cancers12051132.","abstract":"Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase the permeability of cell membranes, a phenomenon known as electroporation. In addition to well-known membrane effects, PEFs can cause profound cytoskeletal disruption. In this review, we summarize the current understanding of cytoskeletal disruption after PEFs. Compiling available studies, we describe PEF-induced cytoskeletal disruption and possible mechanisms of disruption. Additionally, we consider how cytoskeletal alterations contribute to cell-cell and cell-substrate disruption. We conclude with a discussion of cytoskeletal disruption-induced anti-vascular effects of PEFs and consider how a better understanding of cytoskeletal disruption after PEFs may lead to more effective therapies.","keywords":"Ect Ire actin cancer cell junctions cytoskeleton electroporation intermediate filaments mechanobiology microtubules nsPEFs pulsed electric fields vascular lock","issn":"2072-6694 (Print) 2072-6694","doi":"10.3390/cancers12051132","year":"2020","bibtex":"@article{RN133,\n author = {Graybill, P. M. and Davalos, R. V.},\n title = {Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies},\n journal = {Cancers (Basel)},\n volume = {12},\n number = {5},\n note = {2072-6694\nGraybill, Philip M\nOrcid: 0000-0002-2057-7478\nDavalos, Rafael V\nOrcid: 0000-0003-1503-9509\nP01 CA207206/CA/NCI NIH HHS/United States\nP01CA207206/NH/NIH HHS/United States\nJournal Article\nReview\nSwitzerland\n2020/05/06\nCancers (Basel). 2020 Apr 30;12(5):1132. doi: 10.3390/cancers12051132.},\n abstract = {Pulsed electric fields (PEFs) have become clinically important through the success of Irreversible Electroporation (IRE), Electrochemotherapy (ECT), and nanosecond PEFs (nsPEFs) for the treatment of tumors. PEFs increase the permeability of cell membranes, a phenomenon known as electroporation. In addition to well-known membrane effects, PEFs can cause profound cytoskeletal disruption. In this review, we summarize the current understanding of cytoskeletal disruption after PEFs. Compiling available studies, we describe PEF-induced cytoskeletal disruption and possible mechanisms of disruption. Additionally, we consider how cytoskeletal alterations contribute to cell-cell and cell-substrate disruption. We conclude with a discussion of cytoskeletal disruption-induced anti-vascular effects of PEFs and consider how a better understanding of cytoskeletal disruption after PEFs may lead to more effective therapies.},\n keywords = {Ect\nIre\nactin\ncancer\ncell junctions\ncytoskeleton\nelectroporation\nintermediate filaments\nmechanobiology\nmicrotubules\nnsPEFs\npulsed electric fields\nvascular lock},\n ISSN = {2072-6694 (Print)\n2072-6694},\n DOI = {10.3390/cancers12051132},\n year = {2020},\n type = {Journal Article}\n}\n\n","author_short":["Graybill, P. M.","Davalos, R. V."],"key":"RN133","id":"RN133","bibbaseid":"graybill-davalos-cytoskeletaldisruptionafterelectroporationanditssignificancetopulsedelectricfieldtherapies-2020","role":"author","urls":{},"keyword":["Ect Ire actin cancer cell junctions cytoskeleton electroporation intermediate filaments mechanobiology microtubules nsPEFs pulsed electric fields vascular lock"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/network/files/bdNBTZRXTsoHCgpbh","dataSources":["D4zENc4BfFNBwSYYJ","ZPLjameRikygaiM9B","3XfNmZkLe6o8CvECW","fJQsxtBoqymHQG6tL","LzxgEApraxMPkLTMn","Z2THpXfLYEJf3CB8p"],"keywords":["ect ire actin cancer cell junctions cytoskeleton electroporation intermediate filaments mechanobiology microtubules nspefs pulsed electric fields vascular lock"],"search_terms":["cytoskeletal","disruption","electroporation","significance","pulsed","electric","field","therapies","graybill","davalos"],"title":"Cytoskeletal Disruption after Electroporation and Its Significance to Pulsed Electric Field Therapies","year":2020}