@article{groheux_18f-fdg_2013,
	title = {{18F}-{FDG} {PET}/{CT} in staging patients with locally advanced or inflammatory breast cancer: comparison to conventional staging},
	volume = {54},
	issn = {1535-5667},
	shorttitle = {{18F}-{FDG} {PET}/{CT} in staging patients with locally advanced or inflammatory breast cancer: comparison to conventional staging},
	url = {http://dx.doi.org/10.2967/jnumed.112.106864},
	abstract = {UNLABELLED: The prognosis of patients with locally advanced breast cancer (LABC) remains poor. We prospectively investigated the impact of (18)F-FDG PET/CT at initial staging in this clinical setting and compared PET/CT performance with that of conventional distant work-up. METHODS: During 60 mo, consecutive patients with LABC (clinical T4 or N2-N3 disease) underwent (18)F-FDG PET/CT. The yield was assessed in the whole group and separately for noninflammatory and inflammatory cancer. The performance of PET/CT was compared with that of a conventional staging approach including bone scanning, chest radiography, or dedicated CT and abdominopelvic sonography or contrast-enhanced CT. RESULTS: 117 patients with inflammatory (n = 35) or noninflammatory (n = 82) LABC were included. (18)F-FDG PET/CT confirmed N3 nodal involvement in stage IIIC patients and revealed unsuspected N3 nodes (infraclavicular, supraclavicular, or internal mammary) in 32 additional patients. Distant metastases were visualized on PET/CT in 43 patients (46\% of patients with inflammatory carcinoma and 33\% of those with noninflammatory LABC). Overall, (18)F-FDG PET/CT changed the clinical stage in 61 patients (52\%). Unguided conventional imaging detected metastases in only 28 of the 43 patients classified M1 with PET/CT (65\%). (18)F-FDG PET/CT outperformed conventional imaging for bone metastases, distant lymph nodes, and liver metastases, whereas CT was more sensitive for lung metastases. The accuracy in diagnosing bone lesions was 89.7\% for planar bone scanning versus 98.3\% for (18)F-FDG PET/CT. The accuracy in diagnosing lung metastases was 98.3\% for dedicated CT versus 97.4\% for (18)F-FDG PET/CT. CONCLUSION: (18)F-FDG PET/CT had the advantage of allowing chest, abdomen and bone to be examined in a single session. Almost all distant lesions detected by conventional imaging were depicted with PET/CT, which also showed additional lesions.},
	number = {1},
	journal = {J Nucl Med},
	author = {Groheux, David and Giacchetti, Sylvie and Delord, Marc and Hindié, Elif and Vercellino, Laetitia and Cuvier, Caroline and Toubert, Marie-Elisabeth and Merlet, Pascal and Hennequin, Christophe and Espié, Marc},
	year = {2013},
	pages = {5--11},
}

{"_id":"m4bgvmRMQvPmS9k2R","bibbaseid":"groheux-giacchetti-delord-hindi-vercellino-cuvier-toubert-merlet-etal-18ffdgpetctinstagingpatientswithlocallyadvancedorinflammatorybreastcancercomparisontoconventionalstaging-2013","author_short":["Groheux, D.","Giacchetti, S.","Delord, M.","Hindié, E.","Vercellino, L.","Cuvier, C.","Toubert, M.","Merlet, P.","Hennequin, C.","Espié, M."],"bibdata":{"bibtype":"article","type":"article","title":"18F-FDG PET/CT in staging patients with locally advanced or inflammatory breast cancer: comparison to conventional staging","volume":"54","issn":"1535-5667","shorttitle":"18F-FDG PET/CT in staging patients with locally advanced or inflammatory breast cancer: comparison to conventional staging","url":"http://dx.doi.org/10.2967/jnumed.112.106864","abstract":"UNLABELLED: The prognosis of patients with locally advanced breast cancer (LABC) remains poor. We prospectively investigated the impact of (18)F-FDG PET/CT at initial staging in this clinical setting and compared PET/CT performance with that of conventional distant work-up. METHODS: During 60 mo, consecutive patients with LABC (clinical T4 or N2-N3 disease) underwent (18)F-FDG PET/CT. The yield was assessed in the whole group and separately for noninflammatory and inflammatory cancer. The performance of PET/CT was compared with that of a conventional staging approach including bone scanning, chest radiography, or dedicated CT and abdominopelvic sonography or contrast-enhanced CT. RESULTS: 117 patients with inflammatory (n = 35) or noninflammatory (n = 82) LABC were included. (18)F-FDG PET/CT confirmed N3 nodal involvement in stage IIIC patients and revealed unsuspected N3 nodes (infraclavicular, supraclavicular, or internal mammary) in 32 additional patients. Distant metastases were visualized on PET/CT in 43 patients (46% of patients with inflammatory carcinoma and 33% of those with noninflammatory LABC). Overall, (18)F-FDG PET/CT changed the clinical stage in 61 patients (52%). Unguided conventional imaging detected metastases in only 28 of the 43 patients classified M1 with PET/CT (65%). (18)F-FDG PET/CT outperformed conventional imaging for bone metastases, distant lymph nodes, and liver metastases, whereas CT was more sensitive for lung metastases. The accuracy in diagnosing bone lesions was 89.7% for planar bone scanning versus 98.3% for (18)F-FDG PET/CT. The accuracy in diagnosing lung metastases was 98.3% for dedicated CT versus 97.4% for (18)F-FDG PET/CT. CONCLUSION: (18)F-FDG PET/CT had the advantage of allowing chest, abdomen and bone to be examined in a single session. Almost all distant lesions detected by conventional imaging were depicted with PET/CT, which also showed additional lesions.","number":"1","journal":"J Nucl Med","author":[{"propositions":[],"lastnames":["Groheux"],"firstnames":["David"],"suffixes":[]},{"propositions":[],"lastnames":["Giacchetti"],"firstnames":["Sylvie"],"suffixes":[]},{"propositions":[],"lastnames":["Delord"],"firstnames":["Marc"],"suffixes":[]},{"propositions":[],"lastnames":["Hindié"],"firstnames":["Elif"],"suffixes":[]},{"propositions":[],"lastnames":["Vercellino"],"firstnames":["Laetitia"],"suffixes":[]},{"propositions":[],"lastnames":["Cuvier"],"firstnames":["Caroline"],"suffixes":[]},{"propositions":[],"lastnames":["Toubert"],"firstnames":["Marie-Elisabeth"],"suffixes":[]},{"propositions":[],"lastnames":["Merlet"],"firstnames":["Pascal"],"suffixes":[]},{"propositions":[],"lastnames":["Hennequin"],"firstnames":["Christophe"],"suffixes":[]},{"propositions":[],"lastnames":["Espié"],"firstnames":["Marc"],"suffixes":[]}],"year":"2013","pages":"5–11","bibtex":"@article{groheux_18f-fdg_2013,\n\ttitle = {{18F}-{FDG} {PET}/{CT} in staging patients with locally advanced or inflammatory breast cancer: comparison to conventional staging},\n\tvolume = {54},\n\tissn = {1535-5667},\n\tshorttitle = {{18F}-{FDG} {PET}/{CT} in staging patients with locally advanced or inflammatory breast cancer: comparison to conventional staging},\n\turl = {http://dx.doi.org/10.2967/jnumed.112.106864},\n\tabstract = {UNLABELLED: The prognosis of patients with locally advanced breast cancer (LABC) remains poor. We prospectively investigated the impact of (18)F-FDG PET/CT at initial staging in this clinical setting and compared PET/CT performance with that of conventional distant work-up. METHODS: During 60 mo, consecutive patients with LABC (clinical T4 or N2-N3 disease) underwent (18)F-FDG PET/CT. The yield was assessed in the whole group and separately for noninflammatory and inflammatory cancer. The performance of PET/CT was compared with that of a conventional staging approach including bone scanning, chest radiography, or dedicated CT and abdominopelvic sonography or contrast-enhanced CT. RESULTS: 117 patients with inflammatory (n = 35) or noninflammatory (n = 82) LABC were included. (18)F-FDG PET/CT confirmed N3 nodal involvement in stage IIIC patients and revealed unsuspected N3 nodes (infraclavicular, supraclavicular, or internal mammary) in 32 additional patients. Distant metastases were visualized on PET/CT in 43 patients (46\\% of patients with inflammatory carcinoma and 33\\% of those with noninflammatory LABC). Overall, (18)F-FDG PET/CT changed the clinical stage in 61 patients (52\\%). Unguided conventional imaging detected metastases in only 28 of the 43 patients classified M1 with PET/CT (65\\%). (18)F-FDG PET/CT outperformed conventional imaging for bone metastases, distant lymph nodes, and liver metastases, whereas CT was more sensitive for lung metastases. The accuracy in diagnosing bone lesions was 89.7\\% for planar bone scanning versus 98.3\\% for (18)F-FDG PET/CT. The accuracy in diagnosing lung metastases was 98.3\\% for dedicated CT versus 97.4\\% for (18)F-FDG PET/CT. CONCLUSION: (18)F-FDG PET/CT had the advantage of allowing chest, abdomen and bone to be examined in a single session. Almost all distant lesions detected by conventional imaging were depicted with PET/CT, which also showed additional lesions.},\n\tnumber = {1},\n\tjournal = {J Nucl Med},\n\tauthor = {Groheux, David and Giacchetti, Sylvie and Delord, Marc and Hindié, Elif and Vercellino, Laetitia and Cuvier, Caroline and Toubert, Marie-Elisabeth and Merlet, Pascal and Hennequin, Christophe and Espié, Marc},\n\tyear = {2013},\n\tpages = {5--11},\n}\n\n\n\n","author_short":["Groheux, D.","Giacchetti, S.","Delord, M.","Hindié, E.","Vercellino, L.","Cuvier, C.","Toubert, M.","Merlet, P.","Hennequin, C.","Espié, M."],"key":"groheux_18f-fdg_2013","id":"groheux_18f-fdg_2013","bibbaseid":"groheux-giacchetti-delord-hindi-vercellino-cuvier-toubert-merlet-etal-18ffdgpetctinstagingpatientswithlocallyadvancedorinflammatorybreastcancercomparisontoconventionalstaging-2013","role":"author","urls":{"Paper":"http://dx.doi.org/10.2967/jnumed.112.106864"},"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"http://bibbase.org/zotero/biblioial","dataSources":["ftoP3zPyb2N3b9Noc"],"keywords":[],"search_terms":["18f","fdg","pet","staging","patients","locally","advanced","inflammatory","breast","cancer","comparison","conventional","staging","groheux","giacchetti","delord","hindié","vercellino","cuvier","toubert","merlet","hennequin","espié"],"title":"18F-FDG PET/CT in staging patients with locally advanced or inflammatory breast cancer: comparison to conventional staging","year":2013}