A new model for blunt liver injuries in the swine. Grottke, O., Braunschweig, T., Philippen, B., Gatzweiler, K., Gronloh, N., Staat, M., Rossaint, R., & Tolba, R. European Surgical Research, 44(2):65-73, Karger Publishers, 1, 2010. ![A new model for blunt liver injuries in the swine [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website doi abstract bibtex BACKGROUND: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. MATERIALS AND METHODS: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 +/- 19 N (n = 4) or 355 +/- 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. RESULTS: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 +/- 35 N, both the survival time (30 +/- 9 min; p = 0.006) and blood loss (68 +/- 16 ml min(-1), p = 0.002) were significantly different as compared to injuries with 224 +/- 19 N (survival time: 76 +/- 20 min, blood loss: 23 +/- 4 ml min(-1)). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. CONCLUSION: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.
@article{
title = {A new model for blunt liver injuries in the swine},
type = {article},
year = {2010},
keywords = {Coagulopathy,Haemorrhage,Haemostatic agents,Liver,Pig,Trauma},
pages = {65-73},
volume = {44},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/19996600,http://www.karger.com/doi/10.1159/000265053},
month = {1},
publisher = {Karger Publishers},
id = {d576503b-7e97-3d26-94f7-86ba8cba839b},
created = {2014-06-02T18:47:20.000Z},
accessed = {2014-08-18},
file_attached = {false},
profile_id = {93ec0d5b-403c-3f87-b702-40b6362f05e6},
last_modified = {2018-12-30T15:59:38.195Z},
read = {false},
starred = {false},
authored = {true},
confirmed = {true},
hidden = {false},
citation_key = {grottke2009new},
source_type = {article},
private_publication = {false},
abstract = {BACKGROUND: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. MATERIALS AND METHODS: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 +/- 19 N (n = 4) or 355 +/- 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. RESULTS: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 +/- 35 N, both the survival time (30 +/- 9 min; p = 0.006) and blood loss (68 +/- 16 ml min(-1), p = 0.002) were significantly different as compared to injuries with 224 +/- 19 N (survival time: 76 +/- 20 min, blood loss: 23 +/- 4 ml min(-1)). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. CONCLUSION: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.},
bibtype = {article},
author = {Grottke, Oliver and Braunschweig, T. and Philippen, B. and Gatzweiler, K.H. and Gronloh, N. and Staat, Manfred and Rossaint, Rolf and Tolba, Rene},
doi = {10.1159/000265053},
journal = {European Surgical Research},
number = {2}
}
Downloads: 0
{"_id":"XfYKFpuEypcuQGQCr","bibbaseid":"grottke-braunschweig-philippen-gatzweiler-gronloh-staat-rossaint-tolba-anewmodelforbluntliverinjuriesintheswine-2010","authorIDs":["5dba9b3cdd3901df010000ff","5dbc2e733d8602de01000053","jhiQiuMkuDQBRuuJ8"],"author_short":["Grottke, O.","Braunschweig, T.","Philippen, B.","Gatzweiler, K.","Gronloh, N.","Staat, M.","Rossaint, R.","Tolba, R."],"bibdata":{"title":"A new model for blunt liver injuries in the swine","type":"article","year":"2010","keywords":"Coagulopathy,Haemorrhage,Haemostatic agents,Liver,Pig,Trauma","pages":"65-73","volume":"44","websites":"http://www.ncbi.nlm.nih.gov/pubmed/19996600,http://www.karger.com/doi/10.1159/000265053","month":"1","publisher":"Karger Publishers","id":"d576503b-7e97-3d26-94f7-86ba8cba839b","created":"2014-06-02T18:47:20.000Z","accessed":"2014-08-18","file_attached":false,"profile_id":"93ec0d5b-403c-3f87-b702-40b6362f05e6","last_modified":"2018-12-30T15:59:38.195Z","read":false,"starred":false,"authored":"true","confirmed":"true","hidden":false,"citation_key":"grottke2009new","source_type":"article","private_publication":false,"abstract":"BACKGROUND: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. MATERIALS AND METHODS: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 +/- 19 N (n = 4) or 355 +/- 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. RESULTS: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 +/- 35 N, both the survival time (30 +/- 9 min; p = 0.006) and blood loss (68 +/- 16 ml min(-1), p = 0.002) were significantly different as compared to injuries with 224 +/- 19 N (survival time: 76 +/- 20 min, blood loss: 23 +/- 4 ml min(-1)). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. CONCLUSION: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.","bibtype":"article","author":"Grottke, Oliver and Braunschweig, T. and Philippen, B. and Gatzweiler, K.H. and Gronloh, N. and Staat, Manfred and Rossaint, Rolf and Tolba, Rene","doi":"10.1159/000265053","journal":"European Surgical Research","number":"2","bibtex":"@article{\n title = {A new model for blunt liver injuries in the swine},\n type = {article},\n year = {2010},\n keywords = {Coagulopathy,Haemorrhage,Haemostatic agents,Liver,Pig,Trauma},\n pages = {65-73},\n volume = {44},\n websites = {http://www.ncbi.nlm.nih.gov/pubmed/19996600,http://www.karger.com/doi/10.1159/000265053},\n month = {1},\n publisher = {Karger Publishers},\n id = {d576503b-7e97-3d26-94f7-86ba8cba839b},\n created = {2014-06-02T18:47:20.000Z},\n accessed = {2014-08-18},\n file_attached = {false},\n profile_id = {93ec0d5b-403c-3f87-b702-40b6362f05e6},\n last_modified = {2018-12-30T15:59:38.195Z},\n read = {false},\n starred = {false},\n authored = {true},\n confirmed = {true},\n hidden = {false},\n citation_key = {grottke2009new},\n source_type = {article},\n private_publication = {false},\n abstract = {BACKGROUND: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. MATERIALS AND METHODS: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 +/- 19 N (n = 4) or 355 +/- 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. RESULTS: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 +/- 35 N, both the survival time (30 +/- 9 min; p = 0.006) and blood loss (68 +/- 16 ml min(-1), p = 0.002) were significantly different as compared to injuries with 224 +/- 19 N (survival time: 76 +/- 20 min, blood loss: 23 +/- 4 ml min(-1)). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. CONCLUSION: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.},\n bibtype = {article},\n author = {Grottke, Oliver and Braunschweig, T. and Philippen, B. and Gatzweiler, K.H. and Gronloh, N. and Staat, Manfred and Rossaint, Rolf and Tolba, Rene},\n doi = {10.1159/000265053},\n journal = {European Surgical Research},\n number = {2}\n}","author_short":["Grottke, O.","Braunschweig, T.","Philippen, B.","Gatzweiler, K.","Gronloh, N.","Staat, M.","Rossaint, R.","Tolba, R."],"urls":{"Website":"http://www.ncbi.nlm.nih.gov/pubmed/19996600,http://www.karger.com/doi/10.1159/000265053"},"biburl":"https://bibbase.org/service/mendeley/93ec0d5b-403c-3f87-b702-40b6362f05e6","bibbaseid":"grottke-braunschweig-philippen-gatzweiler-gronloh-staat-rossaint-tolba-anewmodelforbluntliverinjuriesintheswine-2010","role":"author","keyword":["Coagulopathy","Haemorrhage","Haemostatic agents","Liver","Pig","Trauma"],"metadata":{"authorlinks":{"staat, m":"https://bibbase.org/service/mendeley/93ec0d5b-403c-3f87-b702-40b6362f05e6"}},"downloads":0},"bibtype":"article","creationDate":"2019-10-31T08:28:44.273Z","downloads":0,"keywords":["coagulopathy","haemorrhage","haemostatic agents","liver","pig","trauma"],"search_terms":["new","model","blunt","liver","injuries","swine","grottke","braunschweig","philippen","gatzweiler","gronloh","staat","rossaint","tolba"],"title":"A new model for blunt liver injuries in the swine","year":2010,"biburl":"https://bibbase.org/service/mendeley/93ec0d5b-403c-3f87-b702-40b6362f05e6","dataSources":["i5FJs3p7i69258A5p","ya2CyA73rpZseyrZ8","2252seNhipfTmjEBQ"]}