A new model for blunt liver injuries in the swine. Grottke, O., Braunschweig, T., Philippen, B., Gatzweiler, K., Gronloh, N., Staat, M., Rossaint, R., & Tolba, R. European Surgical Research, 44(2):65-73, Karger Publishers, 1, 2010. ![A new model for blunt liver injuries in the swine [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website doi abstract bibtex BACKGROUND: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. MATERIALS AND METHODS: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 +/- 19 N (n = 4) or 355 +/- 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. RESULTS: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 +/- 35 N, both the survival time (30 +/- 9 min; p = 0.006) and blood loss (68 +/- 16 ml min(-1), p = 0.002) were significantly different as compared to injuries with 224 +/- 19 N (survival time: 76 +/- 20 min, blood loss: 23 +/- 4 ml min(-1)). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. CONCLUSION: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.
@article{
title = {A new model for blunt liver injuries in the swine},
type = {article},
year = {2010},
keywords = {Coagulopathy,Haemorrhage,Haemostatic agents,Liver,Pig,Trauma},
pages = {65-73},
volume = {44},
websites = {http://www.ncbi.nlm.nih.gov/pubmed/19996600,http://www.karger.com/doi/10.1159/000265053},
month = {1},
publisher = {Karger Publishers},
id = {d576503b-7e97-3d26-94f7-86ba8cba839b},
created = {2014-06-02T18:47:20.000Z},
accessed = {2014-08-18},
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last_modified = {2018-12-30T15:59:38.195Z},
read = {false},
starred = {false},
authored = {true},
confirmed = {true},
hidden = {false},
citation_key = {grottke2009new},
source_type = {article},
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abstract = {BACKGROUND: To elaborate the impact of new haemostatic agents we developed an instrument for the pressure-controlled induction of blunt liver injuries in a porcine animal model. MATERIALS AND METHODS: A dilutional coagulopathy of 80% of animal blood volume was induced in 9 anaesthetized pigs. Animals were randomly assigned to be injured with a force of 112 Newton (N) (n = 1), 224 +/- 19 N (n = 4) or 355 +/- 35 N (n = 4). The impact of injury was measured by blood loss, survival time and coagulation parameters. Liver histology was obtained to evaluate the degree of liver injury. RESULTS: The profound haemodilution resulted in a significant alteration of all coagulation parameters. After inflicting the injury with 355 +/- 35 N, both the survival time (30 +/- 9 min; p = 0.006) and blood loss (68 +/- 16 ml min(-1), p = 0.002) were significantly different as compared to injuries with 224 +/- 19 N (survival time: 76 +/- 20 min, blood loss: 23 +/- 4 ml min(-1)). In contrast, an injury with 112 N led to an insignificant blood loss of only 239 ml. CONCLUSION: We developed a pressure-controlled clamp that allows for the induction of blunt liver traumas with highly reproducible injuries with a positive correlation with blood loss and survival.},
bibtype = {article},
author = {Grottke, Oliver and Braunschweig, T. and Philippen, B. and Gatzweiler, K.H. and Gronloh, N. and Staat, Manfred and Rossaint, Rolf and Tolba, Rene},
doi = {10.1159/000265053},
journal = {European Surgical Research},
number = {2}
}
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