The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression. Grunze, H., Vieta, E., Goodwin, G. M, Bowden, C., Licht, R. W, Möller, H., Kasper, S., & WFSBP Task Force On Treatment Guidelines For Bipolar Disorders World J. Biol. Psychiatry, 11(2):81--109, March, 2010. 00000![The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex OBJECTIVES: These guidelines are based on a first edition that was published in 2002, and have been edited and updated with the available scientific evidence until September 2009. Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults. METHODS: The data used for these guidelines have been extracted from a MEDLINE and EMBASE search, from the clinical trial database clinicaltrials.gov, from recent proceedings of key conferences, and from various national and international treatment guidelines. Their scientific rigor was categorised into six levels of evidence (A-F). As these guidelines are intended for clinical use, the scientific evidence was finally assigned different grades of recommendation to ensure practicability. RESULTS: We identified 10 pharmacological monotherapies or combination treatments with at least limited positive evidence for efficacy in bipolar depression, several of them still experimental and backed up only by a single study. Only one medication was considered to be sufficiently studied to merit full positive evidence. CONCLUSIONS: Although major advances have been made since the first edition of this guideline in 2002, there are many areas which still need more intense research to optimize treatment. The majority of treatment recommendations is still based on limited data and leaves considerable areas of uncertainty.
@article{grunze_world_2010,
title = {The {World} {Federation} of {Societies} of {Biological} {Psychiatry} ({WFSBP}) {Guidelines} for the {Biological} {Treatment} of {Bipolar} {Disorders}: {Update} 2010 on the treatment of acute bipolar depression},
volume = {11},
issn = {1562-2975},
url = {http://dx.doi.org/10.3109/15622970903555881},
doi = {10.3109/15622970903555881},
abstract = {OBJECTIVES: These guidelines are based on a first edition that was
published in 2002, and have been edited and updated with the available
scientific evidence until September 2009. Their purpose is to supply a
systematic overview of all scientific evidence pertaining to the treatment
of acute bipolar depression in adults. METHODS: The data used for these
guidelines have been extracted from a MEDLINE and EMBASE search, from the
clinical trial database clinicaltrials.gov, from recent proceedings of key
conferences, and from various national and international treatment
guidelines. Their scientific rigor was categorised into six levels of
evidence (A-F). As these guidelines are intended for clinical use, the
scientific evidence was finally assigned different grades of
recommendation to ensure practicability. RESULTS: We identified 10
pharmacological monotherapies or combination treatments with at least
limited positive evidence for efficacy in bipolar depression, several of
them still experimental and backed up only by a single study. Only one
medication was considered to be sufficiently studied to merit full
positive evidence. CONCLUSIONS: Although major advances have been made
since the first edition of this guideline in 2002, there are many areas
which still need more intense research to optimize treatment. The majority
of treatment recommendations is still based on limited data and leaves
considerable areas of uncertainty.},
number = {2},
journal = {World J. Biol. Psychiatry},
author = {Grunze, Heinz and Vieta, Eduard and Goodwin, Guy M and Bowden, Charles and Licht, Rasmus W and Möller, Hans-Jürgen and Kasper, Siegfried and {WFSBP Task Force On Treatment Guidelines For Bipolar Disorders}},
month = mar,
year = {2010},
note = {00000},
keywords = {NEW},
pages = {81--109}
}
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W","Möller, H.","Kasper, S.","WFSBP Task Force On Treatment Guidelines For Bipolar Disorders"],"year":2010,"bibtype":"article","biburl":"https://bibbase.org/zotero/davidlloyd33","bibdata":{"bibtype":"article","type":"article","title":"The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2010 on the treatment of acute bipolar depression","volume":"11","issn":"1562-2975","url":"http://dx.doi.org/10.3109/15622970903555881","doi":"10.3109/15622970903555881","abstract":"OBJECTIVES: These guidelines are based on a first edition that was published in 2002, and have been edited and updated with the available scientific evidence until September 2009. Their purpose is to supply a systematic overview of all scientific evidence pertaining to the treatment of acute bipolar depression in adults. METHODS: The data used for these guidelines have been extracted from a MEDLINE and EMBASE search, from the clinical trial database clinicaltrials.gov, from recent proceedings of key conferences, and from various national and international treatment guidelines. Their scientific rigor was categorised into six levels of evidence (A-F). As these guidelines are intended for clinical use, the scientific evidence was finally assigned different grades of recommendation to ensure practicability. RESULTS: We identified 10 pharmacological monotherapies or combination treatments with at least limited positive evidence for efficacy in bipolar depression, several of them still experimental and backed up only by a single study. Only one medication was considered to be sufficiently studied to merit full positive evidence. CONCLUSIONS: Although major advances have been made since the first edition of this guideline in 2002, there are many areas which still need more intense research to optimize treatment. The majority of treatment recommendations is still based on limited data and leaves considerable areas of uncertainty.","number":"2","journal":"World J. Biol. 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Their purpose is to supply a\nsystematic overview of all scientific evidence pertaining to the treatment\nof acute bipolar depression in adults. METHODS: The data used for these\nguidelines have been extracted from a MEDLINE and EMBASE search, from the\nclinical trial database clinicaltrials.gov, from recent proceedings of key\nconferences, and from various national and international treatment\nguidelines. Their scientific rigor was categorised into six levels of\nevidence (A-F). As these guidelines are intended for clinical use, the\nscientific evidence was finally assigned different grades of\nrecommendation to ensure practicability. RESULTS: We identified 10\npharmacological monotherapies or combination treatments with at least\nlimited positive evidence for efficacy in bipolar depression, several of\nthem still experimental and backed up only by a single study. Only one\nmedication was considered to be sufficiently studied to merit full\npositive evidence. 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