The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approach

The interplay of post-acute COVID-19 syndrome and aging: a biological, clinical and public health approach. Guaraldi, G., Milic, J., Cesari, M., Leibovici, L., Mandreoli, F., Missier, P., Rozzini, R., Cattelan, A. M., Motta, F., Mussini, C., & Cossarizza, A. Ageing Research Reviews, 2022.

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ABSTRACT The post-acute COVID-19 syndrome (PACS) is characterized by the persistence of fluctuating symptoms over three months from the onset of the possible or confirmed COVID-19 acute phase. Current data suggests that at least 10% of people with previously documented infection may develop PACS, and up to 50–80% of prevalence is reported among survivors after hospital discharge. This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2. This hypothesis will be argued from biological, clinical and public health view, addressing three main questions: (i) does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS?; (ii) do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases?; (iii) is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID?. A particular focus will be given to the well-being of people with PACS that could be assessed by the intrinsic capacity model and support the definition of the healthy aging trajectory.

@article{guaraldi_interplay_2022,
	title = {The interplay of post-acute {COVID}-19 syndrome and aging: a biological, clinical and public health approach},
	issn = {1568-1637},
	url = {https://www.sciencedirect.com/science/article/pii/S1568163722001283},
	doi = {https://doi.org/10.1016/j.arr.2022.101686},
	abstract = {ABSTRACT The post-acute COVID-19 syndrome (PACS) is characterized by the persistence of fluctuating symptoms over three months from the onset of the possible or confirmed COVID-19 acute phase. Current data suggests that at least 10\% of people with previously documented infection may develop PACS, and up to 50–80\% of prevalence is reported among survivors after hospital discharge. This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2. This hypothesis will be argued from biological, clinical and public health view, addressing three main questions: (i) does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS?; (ii) do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases?; (iii) is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID?. A particular focus will be given to the well-being of people with PACS that could be assessed by the intrinsic capacity model and support the definition of the healthy aging trajectory.},
	journal = {Ageing Research Reviews},
	author = {Guaraldi, Giovanni and Milic, Jovana and Cesari, Matteo and Leibovici, Leonard and Mandreoli, Federica and Missier, Paolo and Rozzini, Renzo and Cattelan, Anna Maria and Motta, Federico and Mussini, Cristina and Cossarizza, Andrea},
	year = {2022},
	pages = {101686},
}

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Current data suggests that at least 10\\% of people with previously documented infection may develop PACS, and up to 50–80\\% of prevalence is reported among survivors after hospital discharge. This viewpoint will discuss various aspects of PACS, particularly in older adults, with a specific hypothesis to describe PACS as the expression of a modified aging trajectory induced by SARS CoV-2. This hypothesis will be argued from biological, clinical and public health view, addressing three main questions: (i) does SARS-CoV-2-induced alterations in aging trajectories play a role in PACS?; (ii) do people with PACS face immuno-metabolic derangements that lead to increased susceptibility to age-related diseases?; (iii) is it possible to restore the healthy aging trajectory followed by the individual before pre-COVID?. 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