Chromosome fragmentation after irradiation with C ions. Gudowska-Nowak, E., Nasonova, E., Ritter, S., & Scholz, M. Radiotherapy and Oncology, 73(SUPPL. 2):S123-S126, 2004.
Chromosome fragmentation after irradiation with C ions [link]Paper  doi  abstract   bibtex   
The premature chromosome condensation (PCC) technique has been used to compare chromatin breakage and repair in non-cycling CHO-K1 cells following high LET (C ions) and low LET (X-rays) irradiation. For both radiation qualities the average initial number of excess PCC fragments increases linearly with dose. However, the frequency of chromatin breaks follows the pattern of energy deposition and at higher LET values reveals clustering due to the large number of ionizing events being concentrated in a small volume of the cell nucleus. In consequence, the distribution of PCC chromosomes plus excess fragments among cells has followed Poisson statistics after X-ray irradiation while the overdispersion of the frequencies has been observed after C-irradiation indicating that a single particle traversal through a cell nucleus can produce multiple chromatin lesions.
@ARTICLE{Gudowska-Nowak20041,
author={Gudowska-Nowak, E. and Nasonova, E. and Ritter, S. and Scholz, M.},
title={Chromosome fragmentation after irradiation with C ions},
journal={Radiotherapy and Oncology},
year={2004},
volume={73},
number={SUPPL. 2},
pages={S123-S126},
doi={10.1016/S0167-8140(04)80032-X},
url={https://www2.scopus.com/inward/record.uri?eid=2-s2.0-21444448281&doi=10.1016%2fS0167-8140%2804%2980032-X&partnerID=40&md5=8f3bb44f5f2e0656f7274b3fc778331a},
abstract={The premature chromosome condensation (PCC) technique has been used to compare chromatin breakage and repair in non-cycling CHO-K1 cells following high LET (C ions) and low LET (X-rays) irradiation. For both radiation qualities the average initial number of excess PCC fragments increases linearly with dose. However, the frequency of chromatin breaks follows the pattern of energy deposition and at higher LET values reveals clustering due to the large number of ionizing events being concentrated in a small volume of the cell nucleus. In consequence, the distribution of PCC chromosomes plus excess fragments among cells has followed Poisson statistics after X-ray irradiation while the overdispersion of the frequencies has been observed after C-irradiation indicating that a single particle traversal through a cell nucleus can produce multiple chromatin lesions.},
author_keywords={Chromatin fragmentation;  High LET C ions;  PCC technique},
keywords={carbon;  heavy ion, animal cell;  cell line;  cell nucleus;  cell regeneration;  Chinese hamster;  chromatin;  chromatin assembly and disassembly;  chromosome;  conference paper;  ionizing radiation;  irradiation;  linear energy transfer;  nonhuman;  Poisson distribution;  premature chromosome condensation;  priority journal;  radiation;  radiation dose;  X irradiation;  animal;  article;  CHO cell;  chromosome aberration;  DNA repair;  hamster, Animals;  Carbon;  CHO Cells;  Chromosome Aberrations;  Cricetinae;  DNA Repair;  Heavy Ions;  Linear Energy Transfer;  Poisson Distribution},
document_type={Conference Paper},
source={Scopus},
}
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