Contribution of Resident and Circulating Precursors to Tumor-Infiltrating CD8+ T Cell Populations in Lung Cancer

Contribution of Resident and Circulating Precursors to Tumor-Infiltrating CD8+ T Cell Populations in Lung Cancer. Gueguen, P., Metoikidou, C., Dupic, T., Lawand, M., Goudot, C., Baulande, S., Lameiras, S., Lantz, O., Girard, N., Seguin-Givelet, A., Lefevre, M., Mora, T., Walczak, A. M., Waterfall, J. J., & Amigorena, S. Science Immunology, 6(55):eabd5778, January, 2021.
doi abstract bibtex

Tumor-infiltrating lymphocytes (TILs), in general, and especially CD8+ TILs, represent a favorable prognostic factor in non-small cell lung cancer (NSCLC). The tissue origin, regenerative capacities, and differentiation pathways of TIL subpopulations remain poorly understood. Using a combination of single-cell RNA and T cell receptor (TCR) sequencing, we investigate the functional organization of TIL populations in primary NSCLC. We identify two CD8+ TIL subpopulations expressing memory-like gene modules: one is also present in blood (circulating precursors) and the other one in juxtatumor tissue (tissue-resident precursors). In tumors, these two precursor populations converge through a unique transitional state into terminally differentiated cells, often referred to as dysfunctional or exhausted. Differentiation is associated with TCR expansion, and transition from precursor to late-differentiated states correlates with intratumor T cell cycling. These results provide a coherent working model for TIL origin, ontogeny, and functional organization in primary NSCLC.

@article{gueguenContributionResidentCirculating2021,
  title = {Contribution of Resident and Circulating Precursors to Tumor-Infiltrating {{CD8}}+ {{T}} Cell Populations in Lung Cancer},
  author = {Gueguen, Paul and Metoikidou, Christina and Dupic, Thomas and Lawand, Myriam and Goudot, Christel and Baulande, Sylvain and Lameiras, Sonia and Lantz, Olivier and Girard, Nicolas and {Seguin-Givelet}, Agathe and Lefevre, Marine and Mora, Thierry and Walczak, Aleksandra M. and Waterfall, Joshua J. and Amigorena, Sebastian},
  year = {2021},
  month = jan,
  journal = {Science Immunology},
  volume = {6},
  number = {55},
  pages = {eabd5778},
  issn = {2470-9468},
  doi = {10.1126/sciimmunol.abd5778},
  abstract = {Tumor-infiltrating lymphocytes (TILs), in general, and especially CD8+ TILs, represent a favorable prognostic factor in non-small cell lung cancer (NSCLC). The tissue origin, regenerative capacities, and differentiation pathways of TIL subpopulations remain poorly understood. Using a combination of single-cell RNA and T cell receptor (TCR) sequencing, we investigate the functional organization of TIL populations in primary NSCLC. We identify two CD8+ TIL subpopulations expressing memory-like gene modules: one is also present in blood (circulating precursors) and the other one in juxtatumor tissue (tissue-resident precursors). In tumors, these two precursor populations converge through a unique transitional state into terminally differentiated cells, often referred to as dysfunctional or exhausted. Differentiation is associated with TCR expansion, and transition from precursor to late-differentiated states correlates with intratumor T cell cycling. These results provide a coherent working model for TIL origin, ontogeny, and functional organization in primary NSCLC.},
  langid = {english},
  pmid = {33514641},
  keywords = {{Carcinoma, Non-Small-Cell Lung},CD8-Positive T-Lymphocytes,Cell Differentiation,Female,Humans,Lung,Lung Neoplasms,{Lymphocytes, Tumor-Infiltrating},Male,Pneumonectomy,Tumor Microenvironment},
  file = {/home/thomas/snap/zotero-snap/common/Zotero/storage/6DY7NCDE/Gueguen et al. - 2021 - Contribution of resident and circulating precursor.pdf}
}

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