Genomic selection for tar content in Nicotiana tabacum: genetic architecture analysis and model evaluation. Guo, L., Kong, B., Chen, H., Ren, M., Cheng, L., Yang, A., Liang, L., Zan, Y., Si, H., & Cai, C. Frontiers in Plant Science, Frontiers, March, 2026. ![Genomic selection for tar content in Nicotiana tabacum: genetic architecture analysis and model evaluation [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex IntroductionDespite its economic importance, reducing tobacco tar content remains challenging due to its complex genetic basis.MethodsHere, we evaluated 436 diverse tobacco accessions to characterize the genetic architecture of tar content and develop an optimized genomic selection strategy. Based on these findings, sixteen genomic prediction models were assessed using five-fold cross-validation.ResultsGenome-wide association analysis detected no major-effect loci, and regional heritability mapping revealed localized enrichment of small-effect variants, particularly on chromosome 17, indicating a predominantly polygenic architecture. rrBLUP achieved the highest prediction accuracy (0.84) with superior computational efficiency, followed closely by GBM (0.83). The robustness of rrBLUP was further confirmed in an independent panel of 36 accessions (Pearson r = 0.888).DiscussionTogether, our results demonstrate that tobacco tar content is governed by dispersed small-effect loci with regional aggregation and establish rrBLUP as a robust and practical model for genome-wide prediction, providing methodological guidance for low-tar tobacco breeding.
@article{guo_genomic_2026,
title = {Genomic selection for tar content in {Nicotiana} tabacum: genetic architecture analysis and model evaluation},
volume = {17},
issn = {1664-462X},
shorttitle = {Genomic selection for tar content in {Nicotiana} tabacum},
url = {https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2026.1721129/full},
doi = {10.3389/fpls.2026.1721129},
abstract = {IntroductionDespite its economic importance, reducing tobacco tar content remains challenging due to its complex genetic basis.MethodsHere, we evaluated 436 diverse tobacco accessions to characterize the genetic architecture of tar content and develop an optimized genomic selection strategy. Based on these findings, sixteen genomic prediction models were assessed using five-fold cross-validation.ResultsGenome-wide association analysis detected no major-effect loci, and regional heritability mapping revealed localized enrichment of small-effect variants, particularly on chromosome 17, indicating a predominantly polygenic architecture. rrBLUP achieved the highest prediction accuracy (0.84) with superior computational efficiency, followed closely by GBM (0.83). The robustness of rrBLUP was further confirmed in an independent panel of 36 accessions (Pearson r = 0.888).DiscussionTogether, our results demonstrate that tobacco tar content is governed by dispersed small-effect loci with regional aggregation and establish rrBLUP as a robust and practical model for genome-wide prediction, providing methodological guidance for low-tar tobacco breeding.},
language = {English},
urldate = {2026-04-10},
journal = {Frontiers in Plant Science},
publisher = {Frontiers},
author = {Guo, Linjie and Kong, Bo and Chen, Hui and Ren, Min and Cheng, Lirui and Yang, Aiguo and Liang, Lei and Zan, Yanjun and Si, Huan and Cai, Changchun},
month = mar,
year = {2026},
keywords = {genome-wide association analysis, genomic selection, model evaluation, tar content, tobacco},
}
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{"_id":"7WBpjf7CZxMjrqaTf","bibbaseid":"guo-kong-chen-ren-cheng-yang-liang-zan-etal-genomicselectionfortarcontentinnicotianatabacumgeneticarchitectureanalysisandmodelevaluation-2026","author_short":["Guo, L.","Kong, B.","Chen, H.","Ren, M.","Cheng, L.","Yang, A.","Liang, L.","Zan, Y.","Si, H.","Cai, C."],"bibdata":{"bibtype":"article","type":"article","title":"Genomic selection for tar content in Nicotiana tabacum: genetic architecture analysis and model evaluation","volume":"17","issn":"1664-462X","shorttitle":"Genomic selection for tar content in Nicotiana tabacum","url":"https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2026.1721129/full","doi":"10.3389/fpls.2026.1721129","abstract":"IntroductionDespite its economic importance, reducing tobacco tar content remains challenging due to its complex genetic basis.MethodsHere, we evaluated 436 diverse tobacco accessions to characterize the genetic architecture of tar content and develop an optimized genomic selection strategy. Based on these findings, sixteen genomic prediction models were assessed using five-fold cross-validation.ResultsGenome-wide association analysis detected no major-effect loci, and regional heritability mapping revealed localized enrichment of small-effect variants, particularly on chromosome 17, indicating a predominantly polygenic architecture. rrBLUP achieved the highest prediction accuracy (0.84) with superior computational efficiency, followed closely by GBM (0.83). The robustness of rrBLUP was further confirmed in an independent panel of 36 accessions (Pearson r = 0.888).DiscussionTogether, our results demonstrate that tobacco tar content is governed by dispersed small-effect loci with regional aggregation and establish rrBLUP as a robust and practical model for genome-wide prediction, providing methodological guidance for low-tar tobacco breeding.","language":"English","urldate":"2026-04-10","journal":"Frontiers in Plant Science","publisher":"Frontiers","author":[{"propositions":[],"lastnames":["Guo"],"firstnames":["Linjie"],"suffixes":[]},{"propositions":[],"lastnames":["Kong"],"firstnames":["Bo"],"suffixes":[]},{"propositions":[],"lastnames":["Chen"],"firstnames":["Hui"],"suffixes":[]},{"propositions":[],"lastnames":["Ren"],"firstnames":["Min"],"suffixes":[]},{"propositions":[],"lastnames":["Cheng"],"firstnames":["Lirui"],"suffixes":[]},{"propositions":[],"lastnames":["Yang"],"firstnames":["Aiguo"],"suffixes":[]},{"propositions":[],"lastnames":["Liang"],"firstnames":["Lei"],"suffixes":[]},{"propositions":[],"lastnames":["Zan"],"firstnames":["Yanjun"],"suffixes":[]},{"propositions":[],"lastnames":["Si"],"firstnames":["Huan"],"suffixes":[]},{"propositions":[],"lastnames":["Cai"],"firstnames":["Changchun"],"suffixes":[]}],"month":"March","year":"2026","keywords":"genome-wide association analysis, genomic selection, model evaluation, tar content, tobacco","bibtex":"@article{guo_genomic_2026,\n\ttitle = {Genomic selection for tar content in {Nicotiana} tabacum: genetic architecture analysis and model evaluation},\n\tvolume = {17},\n\tissn = {1664-462X},\n\tshorttitle = {Genomic selection for tar content in {Nicotiana} tabacum},\n\turl = {https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2026.1721129/full},\n\tdoi = {10.3389/fpls.2026.1721129},\n\tabstract = {IntroductionDespite its economic importance, reducing tobacco tar content remains challenging due to its complex genetic basis.MethodsHere, we evaluated 436 diverse tobacco accessions to characterize the genetic architecture of tar content and develop an optimized genomic selection strategy. Based on these findings, sixteen genomic prediction models were assessed using five-fold cross-validation.ResultsGenome-wide association analysis detected no major-effect loci, and regional heritability mapping revealed localized enrichment of small-effect variants, particularly on chromosome 17, indicating a predominantly polygenic architecture. rrBLUP achieved the highest prediction accuracy (0.84) with superior computational efficiency, followed closely by GBM (0.83). 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