@article{RN210,
   author = {Gupta, L. and Hofman, P. A. M. and Besseling, R. M. H. and Jansen, J. F. A. and Backes, W. H.},
   title = {Abnormal Blood Oxygen Level-Dependent Fluctuations in Focal Cortical Dysplasia and the Perilesional Zone: Initial Findings},
   journal = {AJNR Am J Neuroradiol},
   volume = {39},
   number = {7},
   pages = {1310-1315},
   note = {Gupta, L
Hofman, P A M
Besseling, R M H
Jansen, J F A
Backes, W H
eng
Research Support, Non-U.S. Gov't
2018/05/26 06:00
AJNR Am J Neuroradiol. 2018 Jul;39(7):1310-1315. doi: 10.3174/ajnr.A5684. Epub 2018 May 24.},
   abstract = {BACKGROUND AND PURPOSE: Focal cortical dysplasia is a common cause of intractable epilepsy for which neurosurgery is an option. Delineations of a focal cortical dysplasia lesion on structural brain images may not necessarily reflect the functional borders of normal tissue. Our objective was to determine whether abnormalities in spontaneous blood oxygen level-dependent fluctuations arise in focal cortical dysplasia lesions and proximal regions. MATERIALS AND METHODS: Fourteen patients with focal cortical dysplasia-related epilepsy and 16 healthy controls underwent structural and resting-state functional MR imaging. Three known blood oxygen level-dependent measures were determined, including the fractional amplitude of low-frequency fluctuations, regional homogeneity, and wavelet entropy. These measures were evaluated in the lesion and perilesional zone and normalized to the contralateral cortex of patients with focal cortical dysplasia and healthy controls. RESULTS: Patients showed significantly decreased fractional amplitude of low-frequency fluctuations and increased wavelet entropy in the focal cortical dysplasia lesion and the perilesional zone (</=2 cm) relative to the contralateral homotopic cortex and the same regions in healthy controls. Regional homogeneity was significantly increased in the focal cortical dysplasia lesion compared with the contralateral homotopic cortex and healthy controls. CONCLUSIONS: Abnormalities in spontaneous blood oxygen level-dependent fluctuations were seen up to 2 cm distant from the radiologically visible boundary. It was demonstrated that functional boundaries go beyond structural boundaries of focal cortical dysplasia lesions. Validation is required to reveal whether this information is valuable for surgical planning and outcome evaluation of focal cortical dysplasia lesions and comparing current results with electrophysiologic analysis.},
   keywords = {Adolescent
Adult
Drug Resistant Epilepsy/etiology
Female
Humans
Magnetic Resonance Imaging/*methods
Male
Malformations of Cortical Development/complications/*diagnostic
imaging/*pathology
Neuroimaging/*methods},
   ISSN = {1936-959X (Electronic)
0195-6108 (Linking)},
   DOI = {10.3174/ajnr.A5684},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/29794237
http://www.ajnr.org/content/ajnr/39/7/1310.full.pdf},
   year = {2018},
   type = {Journal Article}
}

{"_id":"r9zEMLPX6qDuhHrtN","bibbaseid":"gupta-hofman-besseling-jansen-backes-abnormalbloodoxygenleveldependentfluctuationsinfocalcorticaldysplasiaandtheperilesionalzoneinitialfindings-2018","downloads":0,"creationDate":"2018-08-03T14:29:50.082Z","title":"Abnormal Blood Oxygen Level-Dependent Fluctuations in Focal Cortical Dysplasia and the Perilesional Zone: Initial Findings","author_short":["Gupta, L.","Hofman, P. A. M.","Besseling, R. M. H.","Jansen, J. F. A.","Backes, W. H."],"year":2018,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Gupta"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Besseling"],"firstnames":["R.","M.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F.","A."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Abnormal Blood Oxygen Level-Dependent Fluctuations in Focal Cortical Dysplasia and the Perilesional Zone: Initial Findings","journal":"AJNR Am J Neuroradiol","volume":"39","number":"7","pages":"1310-1315","note":"Gupta, L Hofman, P A M Besseling, R M H Jansen, J F A Backes, W H eng Research Support, Non-U.S. Gov't 2018/05/26 06:00 AJNR Am J Neuroradiol. 2018 Jul;39(7):1310-1315. doi: 10.3174/ajnr.A5684. Epub 2018 May 24.","abstract":"BACKGROUND AND PURPOSE: Focal cortical dysplasia is a common cause of intractable epilepsy for which neurosurgery is an option. Delineations of a focal cortical dysplasia lesion on structural brain images may not necessarily reflect the functional borders of normal tissue. Our objective was to determine whether abnormalities in spontaneous blood oxygen level-dependent fluctuations arise in focal cortical dysplasia lesions and proximal regions. MATERIALS AND METHODS: Fourteen patients with focal cortical dysplasia-related epilepsy and 16 healthy controls underwent structural and resting-state functional MR imaging. Three known blood oxygen level-dependent measures were determined, including the fractional amplitude of low-frequency fluctuations, regional homogeneity, and wavelet entropy. These measures were evaluated in the lesion and perilesional zone and normalized to the contralateral cortex of patients with focal cortical dysplasia and healthy controls. RESULTS: Patients showed significantly decreased fractional amplitude of low-frequency fluctuations and increased wavelet entropy in the focal cortical dysplasia lesion and the perilesional zone (</=2 cm) relative to the contralateral homotopic cortex and the same regions in healthy controls. Regional homogeneity was significantly increased in the focal cortical dysplasia lesion compared with the contralateral homotopic cortex and healthy controls. CONCLUSIONS: Abnormalities in spontaneous blood oxygen level-dependent fluctuations were seen up to 2 cm distant from the radiologically visible boundary. It was demonstrated that functional boundaries go beyond structural boundaries of focal cortical dysplasia lesions. Validation is required to reveal whether this information is valuable for surgical planning and outcome evaluation of focal cortical dysplasia lesions and comparing current results with electrophysiologic analysis.","keywords":"Adolescent Adult Drug Resistant Epilepsy/etiology Female Humans Magnetic Resonance Imaging/*methods Male Malformations of Cortical Development/complications/*diagnostic imaging/*pathology Neuroimaging/*methods","issn":"1936-959X (Electronic) 0195-6108 (Linking)","doi":"10.3174/ajnr.A5684","url":"http://www.ncbi.nlm.nih.gov/pubmed/29794237 http://www.ajnr.org/content/ajnr/39/7/1310.full.pdf","year":"2018","bibtex":"@article{RN210,\n author = {Gupta, L. and Hofman, P. A. M. and Besseling, R. M. H. and Jansen, J. F. A. and Backes, W. H.},\n title = {Abnormal Blood Oxygen Level-Dependent Fluctuations in Focal Cortical Dysplasia and the Perilesional Zone: Initial Findings},\n journal = {AJNR Am J Neuroradiol},\n volume = {39},\n number = {7},\n pages = {1310-1315},\n note = {Gupta, L\nHofman, P A M\nBesseling, R M H\nJansen, J F A\nBackes, W H\neng\nResearch Support, Non-U.S. Gov't\n2018/05/26 06:00\nAJNR Am J Neuroradiol. 2018 Jul;39(7):1310-1315. doi: 10.3174/ajnr.A5684. Epub 2018 May 24.},\n abstract = {BACKGROUND AND PURPOSE: Focal cortical dysplasia is a common cause of intractable epilepsy for which neurosurgery is an option. Delineations of a focal cortical dysplasia lesion on structural brain images may not necessarily reflect the functional borders of normal tissue. Our objective was to determine whether abnormalities in spontaneous blood oxygen level-dependent fluctuations arise in focal cortical dysplasia lesions and proximal regions. MATERIALS AND METHODS: Fourteen patients with focal cortical dysplasia-related epilepsy and 16 healthy controls underwent structural and resting-state functional MR imaging. Three known blood oxygen level-dependent measures were determined, including the fractional amplitude of low-frequency fluctuations, regional homogeneity, and wavelet entropy. These measures were evaluated in the lesion and perilesional zone and normalized to the contralateral cortex of patients with focal cortical dysplasia and healthy controls. RESULTS: Patients showed significantly decreased fractional amplitude of low-frequency fluctuations and increased wavelet entropy in the focal cortical dysplasia lesion and the perilesional zone (</=2 cm) relative to the contralateral homotopic cortex and the same regions in healthy controls. Regional homogeneity was significantly increased in the focal cortical dysplasia lesion compared with the contralateral homotopic cortex and healthy controls. CONCLUSIONS: Abnormalities in spontaneous blood oxygen level-dependent fluctuations were seen up to 2 cm distant from the radiologically visible boundary. It was demonstrated that functional boundaries go beyond structural boundaries of focal cortical dysplasia lesions. Validation is required to reveal whether this information is valuable for surgical planning and outcome evaluation of focal cortical dysplasia lesions and comparing current results with electrophysiologic analysis.},\n keywords = {Adolescent\nAdult\nDrug Resistant Epilepsy/etiology\nFemale\nHumans\nMagnetic Resonance Imaging/*methods\nMale\nMalformations of Cortical Development/complications/*diagnostic\nimaging/*pathology\nNeuroimaging/*methods},\n ISSN = {1936-959X (Electronic)\n0195-6108 (Linking)},\n DOI = {10.3174/ajnr.A5684},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/29794237\nhttp://www.ajnr.org/content/ajnr/39/7/1310.full.pdf},\n year = {2018},\n type = {Journal Article}\n}\n\n","author_short":["Gupta, L.","Hofman, P. A. M.","Besseling, R. M. H.","Jansen, J. F. A.","Backes, W. 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