@article{RN195,
   author = {Gupta, L. and Janssens, R. and Vlooswijk, M. C. and Rouhl, R. P. and de Louw, A. and Aldenkamp, A. P. and Ulman, S. and Besseling, R. M. and Hofman, P. A. and van Kranen-Mastenbroek, V. H. and Hilkman, D. M. and Jansen, J. F. and Backes, W. H.},
   title = {Towards prognostic biomarkers from BOLD fluctuations to differentiate a first epileptic seizure from new-onset epilepsy},
   journal = {Epilepsia},
   volume = {58},
   number = {3},
   pages = {476-483},
   note = {Gupta, Lalit
Janssens, Rick
Vlooswijk, Marielle C G
Rouhl, Rob P W
de Louw, Anton
Aldenkamp, Albert P
Ulman, Shrutin
Besseling, Rene M H
Hofman, Paul A M
van Kranen-Mastenbroek, Vivianne H
Hilkman, Danny M
Jansen, Jacobus F A
Backes, Walter H
eng
2017/01/19 06:00
Epilepsia. 2017 Mar;58(3):476-483. doi: 10.1111/epi.13658. Epub 2017 Jan 18.},
   abstract = {OBJECTIVE: The diagnosis of epilepsy cannot be reliably made prior to a patient's second seizure in most cases. Therefore, adequate diagnostic tools are needed to differentiate subjects with a first seizure from those with a seizure preceding the onset of epilepsy. The objective was to explore spontaneous blood oxygen level-dependent (BOLD) fluctuations in subjects with a first-ever seizure and patients with new-onset epilepsy (NOE), and to find characteristic biomarkers for seizure recurrence after the first seizure. METHODS: We examined 17 first-seizure subjects, 19 patients with new-onset epilepsy (NOE), and 18 healthy controls. All subjects underwent clinical investigation and received electroencephalography and resting-state functional magnetic resonance imaging (MRI). The BOLD time series were analyzed in terms of regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFFs). RESULTS: We found significantly stronger amplitudes (higher fALFFs) in patients with NOE relative to first-seizure subjects and healthy controls. The frequency range of 73-198 mHz (slow-3 subband) appeared most useful for discriminating patients with NOE from first-seizure subjects. The ReHo measure did not show any significant differences. SIGNIFICANCE: The fALFF appears to be a noninvasive measure that characterizes spontaneous BOLD fluctuations and shows stronger amplitudes in the slow-3 subband of patients with NOE relative first-seizure subjects and healthy controls. A larger study population with follow-up is required to determine whether fALFF holds promise as a potential biomarker for identifying subjects at increased risk to develop epilepsy.},
   keywords = {Adolescent
Adult
Aged
Aged, 80 and over
Brain/diagnostic imaging/pathology
Electrocardiography
Electroencephalography
Epilepsy/*blood/*diagnostic imaging/etiology/physiopathology
Female
Follow-Up Studies
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen/*blood
Retrospective Studies
Young Adult
*BOLD time series
*First-seizure
*Functional magnetic resonance imaging
*Low frequency oscillations
*New-onset epilepsy
*Regional homogeneity},
   ISSN = {1528-1167 (Electronic)
0013-9580 (Linking)},
   DOI = {10.1111/epi.13658},
   url = {http://www.ncbi.nlm.nih.gov/pubmed/28098938
https://onlinelibrary.wiley.com/doi/full/10.1111/epi.13658},
   year = {2017},
   type = {Journal Article}
}

{"_id":"92LGcE5WMQuWevbkz","bibbaseid":"gupta-janssens-vlooswijk-rouhl-delouw-aldenkamp-ulman-besseling-etal-towardsprognosticbiomarkersfromboldfluctuationstodifferentiateafirstepilepticseizurefromnewonsetepilepsy-2017","downloads":0,"creationDate":"2017-09-02T16:45:18.646Z","title":"Towards prognostic biomarkers from BOLD fluctuations to differentiate a first epileptic seizure from new-onset epilepsy","author_short":["Gupta, L.","Janssens, R.","Vlooswijk, M. C.","Rouhl, R. P.","de Louw, A.","Aldenkamp, A. P.","Ulman, S.","Besseling, R. M.","Hofman, P. A.","van Kranen-Mastenbroek, V. H.","Hilkman, D. M.","Jansen, J. F.","Backes, W. H."],"year":2017,"bibtype":"article","biburl":"https://raw.githubusercontent.com/jansenjfa1/bibbase.github.io/master/jansenjfa.bib","bibdata":{"bibtype":"article","type":"Journal Article","author":[{"propositions":[],"lastnames":["Gupta"],"firstnames":["L."],"suffixes":[]},{"propositions":[],"lastnames":["Janssens"],"firstnames":["R."],"suffixes":[]},{"propositions":[],"lastnames":["Vlooswijk"],"firstnames":["M.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Rouhl"],"firstnames":["R.","P."],"suffixes":[]},{"propositions":["de"],"lastnames":["Louw"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Aldenkamp"],"firstnames":["A.","P."],"suffixes":[]},{"propositions":[],"lastnames":["Ulman"],"firstnames":["S."],"suffixes":[]},{"propositions":[],"lastnames":["Besseling"],"firstnames":["R.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Hofman"],"firstnames":["P.","A."],"suffixes":[]},{"propositions":["van"],"lastnames":["Kranen-Mastenbroek"],"firstnames":["V.","H."],"suffixes":[]},{"propositions":[],"lastnames":["Hilkman"],"firstnames":["D.","M."],"suffixes":[]},{"propositions":[],"lastnames":["Jansen"],"firstnames":["J.","F."],"suffixes":[]},{"propositions":[],"lastnames":["Backes"],"firstnames":["W.","H."],"suffixes":[]}],"title":"Towards prognostic biomarkers from BOLD fluctuations to differentiate a first epileptic seizure from new-onset epilepsy","journal":"Epilepsia","volume":"58","number":"3","pages":"476-483","note":"Gupta, Lalit Janssens, Rick Vlooswijk, Marielle C G Rouhl, Rob P W de Louw, Anton Aldenkamp, Albert P Ulman, Shrutin Besseling, Rene M H Hofman, Paul A M van Kranen-Mastenbroek, Vivianne H Hilkman, Danny M Jansen, Jacobus F A Backes, Walter H eng 2017/01/19 06:00 Epilepsia. 2017 Mar;58(3):476-483. doi: 10.1111/epi.13658. Epub 2017 Jan 18.","abstract":"OBJECTIVE: The diagnosis of epilepsy cannot be reliably made prior to a patient's second seizure in most cases. Therefore, adequate diagnostic tools are needed to differentiate subjects with a first seizure from those with a seizure preceding the onset of epilepsy. The objective was to explore spontaneous blood oxygen level-dependent (BOLD) fluctuations in subjects with a first-ever seizure and patients with new-onset epilepsy (NOE), and to find characteristic biomarkers for seizure recurrence after the first seizure. METHODS: We examined 17 first-seizure subjects, 19 patients with new-onset epilepsy (NOE), and 18 healthy controls. All subjects underwent clinical investigation and received electroencephalography and resting-state functional magnetic resonance imaging (MRI). The BOLD time series were analyzed in terms of regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFFs). RESULTS: We found significantly stronger amplitudes (higher fALFFs) in patients with NOE relative to first-seizure subjects and healthy controls. The frequency range of 73-198 mHz (slow-3 subband) appeared most useful for discriminating patients with NOE from first-seizure subjects. The ReHo measure did not show any significant differences. SIGNIFICANCE: The fALFF appears to be a noninvasive measure that characterizes spontaneous BOLD fluctuations and shows stronger amplitudes in the slow-3 subband of patients with NOE relative first-seizure subjects and healthy controls. A larger study population with follow-up is required to determine whether fALFF holds promise as a potential biomarker for identifying subjects at increased risk to develop epilepsy.","keywords":"Adolescent Adult Aged Aged, 80 and over Brain/diagnostic imaging/pathology Electrocardiography Electroencephalography Epilepsy/*blood/*diagnostic imaging/etiology/physiopathology Female Follow-Up Studies Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Oxygen/*blood Retrospective Studies Young Adult *BOLD time series *First-seizure *Functional magnetic resonance imaging *Low frequency oscillations *New-onset epilepsy *Regional homogeneity","issn":"1528-1167 (Electronic) 0013-9580 (Linking)","doi":"10.1111/epi.13658","url":"http://www.ncbi.nlm.nih.gov/pubmed/28098938 https://onlinelibrary.wiley.com/doi/full/10.1111/epi.13658","year":"2017","bibtex":"@article{RN195,\n author = {Gupta, L. and Janssens, R. and Vlooswijk, M. C. and Rouhl, R. P. and de Louw, A. and Aldenkamp, A. P. and Ulman, S. and Besseling, R. M. and Hofman, P. A. and van Kranen-Mastenbroek, V. H. and Hilkman, D. M. and Jansen, J. F. and Backes, W. H.},\n title = {Towards prognostic biomarkers from BOLD fluctuations to differentiate a first epileptic seizure from new-onset epilepsy},\n journal = {Epilepsia},\n volume = {58},\n number = {3},\n pages = {476-483},\n note = {Gupta, Lalit\nJanssens, Rick\nVlooswijk, Marielle C G\nRouhl, Rob P W\nde Louw, Anton\nAldenkamp, Albert P\nUlman, Shrutin\nBesseling, Rene M H\nHofman, Paul A M\nvan Kranen-Mastenbroek, Vivianne H\nHilkman, Danny M\nJansen, Jacobus F A\nBackes, Walter H\neng\n2017/01/19 06:00\nEpilepsia. 2017 Mar;58(3):476-483. doi: 10.1111/epi.13658. Epub 2017 Jan 18.},\n abstract = {OBJECTIVE: The diagnosis of epilepsy cannot be reliably made prior to a patient's second seizure in most cases. Therefore, adequate diagnostic tools are needed to differentiate subjects with a first seizure from those with a seizure preceding the onset of epilepsy. The objective was to explore spontaneous blood oxygen level-dependent (BOLD) fluctuations in subjects with a first-ever seizure and patients with new-onset epilepsy (NOE), and to find characteristic biomarkers for seizure recurrence after the first seizure. METHODS: We examined 17 first-seizure subjects, 19 patients with new-onset epilepsy (NOE), and 18 healthy controls. All subjects underwent clinical investigation and received electroencephalography and resting-state functional magnetic resonance imaging (MRI). The BOLD time series were analyzed in terms of regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFFs). RESULTS: We found significantly stronger amplitudes (higher fALFFs) in patients with NOE relative to first-seizure subjects and healthy controls. The frequency range of 73-198 mHz (slow-3 subband) appeared most useful for discriminating patients with NOE from first-seizure subjects. The ReHo measure did not show any significant differences. SIGNIFICANCE: The fALFF appears to be a noninvasive measure that characterizes spontaneous BOLD fluctuations and shows stronger amplitudes in the slow-3 subband of patients with NOE relative first-seizure subjects and healthy controls. A larger study population with follow-up is required to determine whether fALFF holds promise as a potential biomarker for identifying subjects at increased risk to develop epilepsy.},\n keywords = {Adolescent\nAdult\nAged\nAged, 80 and over\nBrain/diagnostic imaging/pathology\nElectrocardiography\nElectroencephalography\nEpilepsy/*blood/*diagnostic imaging/etiology/physiopathology\nFemale\nFollow-Up Studies\nHumans\nImage Processing, Computer-Assisted\nMagnetic Resonance Imaging\nMale\nMiddle Aged\nOxygen/*blood\nRetrospective Studies\nYoung Adult\n*BOLD time series\n*First-seizure\n*Functional magnetic resonance imaging\n*Low frequency oscillations\n*New-onset epilepsy\n*Regional homogeneity},\n ISSN = {1528-1167 (Electronic)\n0013-9580 (Linking)},\n DOI = {10.1111/epi.13658},\n url = {http://www.ncbi.nlm.nih.gov/pubmed/28098938\nhttps://onlinelibrary.wiley.com/doi/full/10.1111/epi.13658},\n year = {2017},\n type = {Journal Article}\n}\n\n","author_short":["Gupta, L.","Janssens, R.","Vlooswijk, M. 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