@misc{gupta_k._dexmedetomidine_2016,
	title = {Dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia for appropriate surgical field visibility during modified radical mastectomy with i-gel: {A} randomized control study},
	url = {http://ekja.org/Synapse/Data/PDFData/0011KJAE/kjae-69-573.pdf},
	abstract = {Background: Modified radical mastectomy is associated with appreciable blood loss, while endotracheal intubation leads to elevated hemodynamic responses. The present study aimed to evaluate the clinical efficacy of dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia during modified radical mastectomy with I-Gel. Methods: Sixty adult consenting female patients, of American Society of Anesthesiologists physical status 1 to 2 and aged 4,065 years, were blindly randomized into two groups of 30 patients each. The patients in Group I received intravenous dexmedetomidine at a loading dose of 1 mug/kg over 10 min, followed by maintenance infusion of 0.4 to 0.7 mug/kg/h, while patients in Group II were administered an identical amount of saline infusion until 15 min prior to the end of surgery. The primary end point was bleeding at the surgical field and hemodynamic changes; requirement of isoflurane, intraoperative fentanyl consumption and recovery time were assessed as secondary outcomes. Results: The patients receiving dexmedetomidine infusion showed significantly less bleeding at the surgical field (P {\textless} 0.05). A statistically significant reduction was also observed in the percentage of isoflurane required (0.82 +/- 0.80\%) to maintain the systolic blood pressure between 100 and 110 mmHg in patients receiving dexmedetomidine infusion compared with the Group II (1.50 +/- 0.90\%). The mean intraoperative fentanyl consumption in patients in the Group I was also significantly lower compared with that of the Group II (38.43 +/- 5.40 mug vs. 75.12 +/- 4.60 mug). The mean recovery time from anesthesia did not show any clinically significant difference between the groups. Conclusions: Dexmedetomidine infusion can be used safely to decrease the bleeding at the surgical field with smooth recovery from anesthesia. Copyright © the Korean Society of Anesthesiologists, 2016.},
	journal = {Korean Journal of Anesthesiology},
	author = {{Gupta K.} and {Rastogi B.} and {Gupta P.K.} and {Singh I.} and {Singh V.P.} and {Jain M.}},
	year = {2016},
	keywords = {*adjuvant, *anesthesia, *bleeding, *dexmedetomidine, *dexmedetomidine/ae [Adverse Drug Reaction], *dexmedetomidine/iv [Intravenous Drug Administration], *general anesthesia, *infusion, *modified radical mastectomy, *supraglottic airway device, *visibility, Child, adjuvant therapy, adult, anesthesist, anesthetic recovery, article, artificial ventilation, bradycardia, clinical trial, comparative effectiveness, continuous infusion, controlled clinical trial, controlled study, diclofenac/im [Intramuscular Drug Administration], double blind procedure, electrocardiography, end tidal carbon dioxide tension, female, fentanyl, fentanyl/iv [Intravenous Drug Administration], glycopyrronium/im [Intramuscular Drug Administration], human, isoflurane, isoflurane/cb [Drug Combination], isoflurane/cm [Drug Comparison], loading drug dose, major clinical study, midazolam/iv [Intravenous Drug Administration], middle aged, neostigmine, nitrous oxide plus oxygen/cb [Drug Combination], non invasive blood pressure monitor, operative blood loss, oxygen saturation, palonosetron/iv [Intravenous Drug Administration], postoperative nausea and vomiting/si [Side Effect], preschool child, propofol/cb [Drug Combination], prospective study, randomized controlled trial, respiration depression/si [Side Effect], shivering/si [Side Effect], sodium chloride, supraglottic airway device, surgery, systolic blood pressure, tachycardia, tidal volume, vecuronium}
}

{"_id":"6JKJqYDeBmaQPr55b","bibbaseid":"guptak-rastogib-guptapk-singhi-singhvp-jainm-dexmedetomidineinfusionasananestheticadjuvanttogeneralanesthesiaforappropriatesurgicalfieldvisibilityduringmodifiedradicalmastectomywithigelarandomizedcontrolstudy-2016","downloads":0,"creationDate":"2017-05-12T20:20:57.471Z","title":"Dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia for appropriate surgical field visibility during modified radical mastectomy with i-gel: A randomized control study","author_short":["Gupta K.","Rastogi B.","Gupta P.K.","Singh I.","Singh V.P.","Jain M."],"year":2016,"bibtype":"misc","biburl":"http://bibbase.org/zotero/gxu917","bibdata":{"bibtype":"misc","type":"misc","title":"Dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia for appropriate surgical field visibility during modified radical mastectomy with i-gel: A randomized control study","url":"http://ekja.org/Synapse/Data/PDFData/0011KJAE/kjae-69-573.pdf","abstract":"Background: Modified radical mastectomy is associated with appreciable blood loss, while endotracheal intubation leads to elevated hemodynamic responses. The present study aimed to evaluate the clinical efficacy of dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia during modified radical mastectomy with I-Gel. Methods: Sixty adult consenting female patients, of American Society of Anesthesiologists physical status 1 to 2 and aged 4,065 years, were blindly randomized into two groups of 30 patients each. The patients in Group I received intravenous dexmedetomidine at a loading dose of 1 mug/kg over 10 min, followed by maintenance infusion of 0.4 to 0.7 mug/kg/h, while patients in Group II were administered an identical amount of saline infusion until 15 min prior to the end of surgery. The primary end point was bleeding at the surgical field and hemodynamic changes; requirement of isoflurane, intraoperative fentanyl consumption and recovery time were assessed as secondary outcomes. Results: The patients receiving dexmedetomidine infusion showed significantly less bleeding at the surgical field (P \\textless 0.05). A statistically significant reduction was also observed in the percentage of isoflurane required (0.82 +/- 0.80%) to maintain the systolic blood pressure between 100 and 110 mmHg in patients receiving dexmedetomidine infusion compared with the Group II (1.50 +/- 0.90%). The mean intraoperative fentanyl consumption in patients in the Group I was also significantly lower compared with that of the Group II (38.43 +/- 5.40 mug vs. 75.12 +/- 4.60 mug). The mean recovery time from anesthesia did not show any clinically significant difference between the groups. Conclusions: Dexmedetomidine infusion can be used safely to decrease the bleeding at the surgical field with smooth recovery from anesthesia. Copyright © the Korean Society of Anesthesiologists, 2016.","journal":"Korean Journal of Anesthesiology","author":[{"firstnames":[],"propositions":[],"lastnames":["Gupta K."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Rastogi B."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Gupta P.K."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Singh I."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Singh V.P."],"suffixes":[]},{"firstnames":[],"propositions":[],"lastnames":["Jain M."],"suffixes":[]}],"year":"2016","keywords":"*adjuvant, *anesthesia, *bleeding, *dexmedetomidine, *dexmedetomidine/ae [Adverse Drug Reaction], *dexmedetomidine/iv [Intravenous Drug Administration], *general anesthesia, *infusion, *modified radical mastectomy, *supraglottic airway device, *visibility, Child, adjuvant therapy, adult, anesthesist, anesthetic recovery, article, artificial ventilation, bradycardia, clinical trial, comparative effectiveness, continuous infusion, controlled clinical trial, controlled study, diclofenac/im [Intramuscular Drug Administration], double blind procedure, electrocardiography, end tidal carbon dioxide tension, female, fentanyl, fentanyl/iv [Intravenous Drug Administration], glycopyrronium/im [Intramuscular Drug Administration], human, isoflurane, isoflurane/cb [Drug Combination], isoflurane/cm [Drug Comparison], loading drug dose, major clinical study, midazolam/iv [Intravenous Drug Administration], middle aged, neostigmine, nitrous oxide plus oxygen/cb [Drug Combination], non invasive blood pressure monitor, operative blood loss, oxygen saturation, palonosetron/iv [Intravenous Drug Administration], postoperative nausea and vomiting/si [Side Effect], preschool child, propofol/cb [Drug Combination], prospective study, randomized controlled trial, respiration depression/si [Side Effect], shivering/si [Side Effect], sodium chloride, supraglottic airway device, surgery, systolic blood pressure, tachycardia, tidal volume, vecuronium","bibtex":"@misc{gupta_k._dexmedetomidine_2016,\n\ttitle = {Dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia for appropriate surgical field visibility during modified radical mastectomy with i-gel: {A} randomized control study},\n\turl = {http://ekja.org/Synapse/Data/PDFData/0011KJAE/kjae-69-573.pdf},\n\tabstract = {Background: Modified radical mastectomy is associated with appreciable blood loss, while endotracheal intubation leads to elevated hemodynamic responses. The present study aimed to evaluate the clinical efficacy of dexmedetomidine infusion as an anesthetic adjuvant to general anesthesia during modified radical mastectomy with I-Gel. Methods: Sixty adult consenting female patients, of American Society of Anesthesiologists physical status 1 to 2 and aged 4,065 years, were blindly randomized into two groups of 30 patients each. The patients in Group I received intravenous dexmedetomidine at a loading dose of 1 mug/kg over 10 min, followed by maintenance infusion of 0.4 to 0.7 mug/kg/h, while patients in Group II were administered an identical amount of saline infusion until 15 min prior to the end of surgery. The primary end point was bleeding at the surgical field and hemodynamic changes; requirement of isoflurane, intraoperative fentanyl consumption and recovery time were assessed as secondary outcomes. Results: The patients receiving dexmedetomidine infusion showed significantly less bleeding at the surgical field (P {\\textless} 0.05). A statistically significant reduction was also observed in the percentage of isoflurane required (0.82 +/- 0.80\\%) to maintain the systolic blood pressure between 100 and 110 mmHg in patients receiving dexmedetomidine infusion compared with the Group II (1.50 +/- 0.90\\%). The mean intraoperative fentanyl consumption in patients in the Group I was also significantly lower compared with that of the Group II (38.43 +/- 5.40 mug vs. 75.12 +/- 4.60 mug). The mean recovery time from anesthesia did not show any clinically significant difference between the groups. Conclusions: Dexmedetomidine infusion can be used safely to decrease the bleeding at the surgical field with smooth recovery from anesthesia. Copyright © the Korean Society of Anesthesiologists, 2016.},\n\tjournal = {Korean Journal of Anesthesiology},\n\tauthor = {{Gupta K.} and {Rastogi B.} and {Gupta P.K.} and {Singh I.} and {Singh V.P.} and {Jain M.}},\n\tyear = {2016},\n\tkeywords = {*adjuvant, *anesthesia, *bleeding, *dexmedetomidine, *dexmedetomidine/ae [Adverse Drug Reaction], *dexmedetomidine/iv [Intravenous Drug Administration], *general anesthesia, *infusion, *modified radical mastectomy, *supraglottic airway device, *visibility, Child, adjuvant therapy, adult, anesthesist, anesthetic recovery, article, artificial ventilation, bradycardia, clinical trial, comparative effectiveness, continuous infusion, controlled clinical trial, controlled study, diclofenac/im [Intramuscular Drug Administration], double blind procedure, electrocardiography, end tidal carbon dioxide tension, female, fentanyl, fentanyl/iv [Intravenous Drug Administration], glycopyrronium/im [Intramuscular Drug Administration], human, isoflurane, 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